Clinical trials: Pediatric Patients
Obesity, Childhood
Dissemination and Implementation of Improving Pediatric Obesity Practice Using Prompts
The purpose of this study is to evaluate the dissemination and implementation of electronic health record-based clinical decision support tools for the management of pediatric overweight and obesity in primary care.
- Trial name
- iPOP-UP (NCT05627011)
- Testing
- Improving Pediatric Obesity Practice Using Prompts (iPOP-UP)
- Where
- 3 sites in United States
- Volunteers
- 58,364 people
- Sponsor
- Yale University
Pediatric HD, Bleeding
Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients
The aim of the current pilot study proposal is to compare the use of the purified human fibrinogen concentrate (Fibryga®, Octapharma USA) to cryoprecipitate for the treatment of cardiopulmonary bypass (CPB)-associated bleeding in…
- Trial name
- NCT04376762
- Testing
- Fibrinogen, Cryoprecipitate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Pediatric Cancer
Pediatric Radiation Oncology With Movie Induced Sedation Effect (PROMISE)
PROMISE (Pediatric Radiation Oncology with Movie Induced Sedation Effect) is an interactive incentive-based movie system that integrates with a video surveillance gating module (VisionRT) as an alternative sedation solution for…
- Trial name
- NCT05148078
- Testing
- PROMISE (Pediatric Radiation Oncology with Movie Induced Sedation Effect)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Hereditary Angioedema, Pediatric
Berotralstat Treatment in Children With Hereditary Angioedema
The purpose of this study is to evaluate the pharmacokinetics (PK), safety and effectiveness of berotralstat to determine the appropriate weight-based dose for pediatric participants 2 to < 12 years of age for prophylactic…
- Trial name
- APeX-P (NCT05453968)
- Testing
- Berotralstat
- Where
- 15 sites in Austria, Canada and 8 more
- Volunteers
- 29 people
- Sponsor
- BioCryst Pharmaceuticals
Childhood Obesity
Family Connections: Cultural Adaptation and Feasibility Testing for Rural Latino Communities
There are marked ethnic and rural-urban disparities in the prevalence of childhood obesity (CO). Among Latino/Hispanic children, CO is almost 60% higher than that of non- Latino/Hispanic Whites, and among children in rural areas…
- Trial name
- NCT04731506
- Testing
- Family Connections
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Nebraska
Acute Lymphoblastic Leukemia, Pediatric
Vaccine Immune Recovery After Leukemia
This observational study aims to assess recovery of the immune system and immunity to vaccine-preventable diseases in children, adolescents, and young adults who recently completed treatment for acute lymphoblastic leukemia…
- Trial name
- VIRAL (NCT05622682)
- Testing
- Observational only: Serology and flow cytometry for ALL cohort participants, Observational only: Infection rates
- Where
- 6 sites in United States
- Volunteers
- 89 people
- Sponsor
- Children's Hospital of Philadelphia
Pediatric Feeding Disorder, Chronic, Pediatric Feeding Dysfunction, Acute
Parent Acceptance and Commitment Therapy (PACT) for Parents of Children With Pediatric Feeding Disorder
This is a pilot study of randomized clinical trial of Parent Acceptance and Commitment Therapy (PACT) vs. an attention-control condition (placebo) for improving the mental health of parents of children with pediatric feeding…
- Trial name
- PACT (NCT06001398)
- Testing
- Parent Acceptance and Commitment Therapy (PACT), Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Mercy Hospital Kansas City
Pediatric Crohns Disease, Pediatric Ulcerative Colitis
Peer Mentoring to Improve Self-management in Youth With IBD
This study is a multi-site randomized controlled clinical trial evaluating the efficacy of a peer mentoring program for improving the self-management of youth with IBD.
- Conditions
- Pediatric Crohns Disease, Pediatric Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT03827109
- Testing
- Group educational activities, IBD educational website, Monthly check-in calls from program coordinator
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Kelly Boone
Pediatric Crohn's Disease
Clinical Study of TA-650 in Pediatric Patients With Crohn's Disease
The purpose of this study is to evaluate the efficacy of TA-650 using Pediatric Crohn's Disease Activity Index (PCDAI) in pediatric patients with moderate to severe Crohn's disease after TA-650 administration at a dose of 5 mg/kg…
- Trial name
- NCT01580670
- Testing
- TA-650
- Where
- 7 sites in Japan
- Volunteers
- 14 people
- Sponsor
- Tanabe Pharma Corporation
Pediatric Ulcerative Colitis
Clinical Study of TA-650 in Pediatric Patients With Ulcerative Colitis
The purpose of this study is to evaluate the the efficacy of TA-650 using Clinical activity index (CAI) score and other evaluation indicators in pediatric patients with moderate to severe ulcerative colitis after TA-650…
- Trial name
- NCT01585155
- Testing
- TA-650
- Where
- 7 sites in Japan
- Volunteers
- 21 people
- Sponsor
- Tanabe Pharma Corporation
Pediatric Acute-Onset Neuropsychiatric Syndrome
Phase III Study To Compare The Effect of Panzyga Versus Placebo in Patients With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS/PANDAS)
A Superiority Study To Compare The Effect of Panzyga Versus Placebo in Patients with Pediatric Acute-onset Neuropsychiatric Syndrome
- Trial name
- NCT04508530
- Testing
- Panzyga
- Where
- 12 sites in United States, Italy and 1 more
- Volunteers
- 71 people
- Sponsor
- Octapharma
Pediatric Obesity
Family Focused Community Program to Prevent Type 2 Diabetes in Peripubertal Youth
Over one-third of children and adolescents are overweight and nearly 1 in 5 of them are obese. Metabolic syndrome, a strong predictor of Type 2 diabetes (T2D) and cardiovascular disease (CVD), occurs in up to 44% of obese youth…
- Trial name
- NCT02421198
- Testing
- YMCA Family Diabetes Prevention Program (YFDPP)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Obesity, Pediatric
Redesigning Pediatric Primary Care Obesity Treatment: Virtual House Calls
This study examines a redesign of pediatric primary care overweight/obesity treatment, augmenting typical in-person visits with: (1) direct-to-patient video telehealth to tailor counseling advice to families, (2) that leverages…
- Trial name
- NCT06078774
- Testing
- Virtual Health Coach
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Pediatric Obesity
Parent Involvement in Adolescent Obesity Treatment
A randomized control trial to compare the efficacy of two distinct parent treatments on weight loss maintenance for adolescents with obesity participating in a lifestyle intervention including nutrition education, exercise and…
- Trial name
- TEENS+ (NCT03851796)
- Testing
- TEENS+Parents as Coaches, TEENS+Parent Weight Loss
- Where
- United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
PCOS, Adolescent Obesity
Treating PCOS With Semaglutide vs Active Lifestyle Intervention
Girls with obesity and polycystic ovarian syndrome will receive either glucagon like peptide-1 receptor agonist therapy or a dietary intervention for 12 weeks to decrease the metabolic syndrome, in particular to lower hepatic fat…
- Conditions
- PCOS, Adolescent Obesity, NAFLD
- Trial name
- TEAL (NCT03919929)
- Testing
- Semaglutide 3mg and 7mg [Rybelsus], Weight loss diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Schizophrenia, Pediatric
Safety, Tolerability, and Pharmacokinetics of Lumateperone in Pediatric Patients With Schizophrenia or Schizoaffective Disorder
Study ITI-007-020 is a Phase 1b, multicenter, open-label study to evaluate the safety, tolerability, and PK of lumateperone as treatment for adolescent patients with schizophrenia or schizoaffective disorder.
- Trial name
- NCT04779177
- Testing
- Lumateperone 42 mg, Lumateperone 28 mg
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Central Nervous System Diseases, Pediatric Disorder
Gadopiclenol Pharmacokinetics, Safety and Efficacy in Children < 2 Years of Age
This Phase II open-label, uncontrolled, multicenter trial is designed to investigate the pharmacokinetic (PK) profile of gadopiclenol in plasma, in pediatric patients aged up to 23 months inclusive (term neonates or preterm…
- Conditions
- Central Nervous System Diseases, Pediatric Disorder, Body Indication
- Trial name
- NCT05590884
- Testing
- Gadopiclenol
- Where
- 11 sites in United States, Hungary and 1 more
- Volunteers
- 36 people
- Sponsor
- Guerbet
Hepatic Steatosis, Bariatric Surgery Candidate
Hepatic Mitochondrial Function in Youth
Assess the impact of bariatric surgery on hepatic energy metabolism and glucose and insulin dynamics in obese youth
- Conditions
- Hepatic Steatosis, Bariatric Surgery Candidate, Adolescent Obesity, Obesity
- Trial name
- MANGO (NCT03587727)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Obesity, Childhood
Mechanisms of Obesity and Its Metabolic Complications in Youth
The overarching goal of this project is to determine whether the effect of gut microbiota on human metabolism might be mediated by short chain fatty acids (SCFA) and whether the SCFA might modulate lipid metabolism.
- Trial name
- NCT03454828
- Testing
- obese carbohydrate diet, lean carbohydrate diet
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Yale University
Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL), Ph+ Mixed Phenotype Acute Leukemia (MPAL)
A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
This study is about an anticancer drug called ponatinib which is a tyrosine kinase inhibitor given with chemotherapy to children, teenagers, and young adults up to 21 years of age with Philadelphia Chromosome-Positive Acute…
- Conditions
- Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL), Ph+ Mixed Phenotype Acute Leukemia (MPAL), Philadelphia Chromosome-Like ALL (Ph-like ALL)
- Trial name
- NCT04501614
- Testing
- Ponatinib, Chemotherapy Agents
- Where
- 64 sites in United States, Argentina and 13 more
- Volunteers
- 11 people
- Sponsor
- Takeda