Clinical trials: Pediatric Population
Dental Caries
Isolite and Dental Treatment Under Conscious Sedation
Hypothesis The use of Isolite® system does not produce upper airway obstruction in the pediatric population during dental treatment with conscious sedation.
- Trial name
- NCT01683851
- Testing
- Isolite System
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Stigma
RESPECT: (REsearching Stigma in PEdiatric Cancer Tool)
Researchers want to learn more about the way stigma affects children with cancer and their caregivers. They want to develop two clinical tools to identify and measure stigma in the pediatric cancer population within culturally…
- Trial name
- NCT06470230
- Where
- 4 sites in United States, Guatemala and 1 more
- Volunteers
- 633 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Pain
Pharmacokinetics of Oral Morphine and Pharmacogenomics of CYP2D6 and UGT2B7, in an Urban Pediatric Population Presenting for Elective Surgery
The purpose of this study is to identify and collect samples from children who have taken a single oral dose of the pain medication morphine, and to determine the genetic differences in the way children metabolize (break down in…
- Trial name
- NCT01071499
- Testing
- Morphine
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy, Obese
Reference Values of Aerobic Fitness in the Contemporary Paediatric Population
In most pediatric medical conditions, tremendous progress in pediatrics has significantly improved the overall prognosis and transferred the mortality from childhood to adulthood.
- Trial name
- SAIN&NORMES (NCT04876209)
- Where
- France
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Atopic Dermatitis
Steroid-Sparing Effect With Pimecrolimus in Pediatric Patients With Atopic Dermatitis
This study will investigate the steroid sparing effect of pimecrolimus cream 1% in pediatric atopic dermatitis
- Trial name
- NCT00351052
- Testing
- Pimecrolimus
- Where
- Germany
- Volunteers
- 184 people
- Sponsor
- Novartis
Opioid Consumption, Multimodal Analgesia
Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the…
- Conditions
- Opioid Consumption, Multimodal Analgesia, Acute Appendicitis, Complication of Treatment
- Trial name
- NCT06563349
- Testing
- Intravenous magnesium sulfate, Normal saline infusion
- Where
- Poland
- Volunteers
- 188 people
- Sponsor
- Medical University of Warsaw
Needle Fear, Vaccine Hesitancy
Thimble Mindfulness App and Recovery Patch Descriptions
The goal of this clinical trial is to lessen the pain and fear of needles by using a mindfulness-based app and a recovery patch on pediatric patients between the ages of 5 and 11.
- Trial name
- NCT05980247
- Testing
- Thimble Application
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bianca Edison
Appendicitis Acute
Comparison of Open and Laparoscopic Appendectomy in Pediatric Population
Introduction: In the era of minimally invasive surgery, changing trends are towards laparoscopic surgery, first introduced in 1983.
- Trial name
- Appendicitis (NCT06363318)
- Testing
- Laparoscopic appendicectomy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- King Edward Medical University
Infection Control
Knowledge, Attitude and Practice Survey for Egyptian Dentists About Infection Control in Pediatric Dental Clinics
This study is designed to gather information about knowledge of pediatric dentistry interns towards infection control procedures in pediatric dental clinics, also about their attitude towards the rules and guidelines of infection…
- Trial name
- case-only (NCT03780114)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain Perception
The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electrodiagnostic Testing
Electromyography (EMG) is a useful test for diagnosis and monitoring of lower motor neuron disorders. It is mostly done in conjunction with a Nerve Conduction Study (NCS).
- Trial name
- COMFORTEMG (NCT04337814)
- Testing
- EMLA Cream, Ibuprofen
- Where
- Pakistan
- Volunteers
- 113 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Solid Tumours
Investigating Safety, Tolerability, Efficacy and PK of Olaparib in Paediatric Patients With Solid Tumours
A study to find out whether olaparib is safe and well tolerated when administered to children and adolescents with solid tumours.
- Trial name
- NCT04236414
- Testing
- Olaparib
- Where
- 10 sites in Denmark, France and 4 more
- Volunteers
- 16 people
- Sponsor
- AstraZeneca
Metabolism and Nutrition Disorder
Prospective Evaluation of the Incidence of PICS
Advances in modern medicine and critical care interventions have greatly impacted survival of critically ill patients, but these interventions are not without consequences.
- Trial name
- ProsPICS (NCT03584399)
- Testing
- PICS in critically ill pediatric population
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Indiana University
Mild Traumatic Brain Injury, Concussion
Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population
Brain injuries from trauma are common in children, often resulting in death and disability. Most brain injuries are minor, yet their treatment can be challenging.
- Trial name
- NCT00715949
- Testing
- Immediate Post-concussion Assessment and Cognitive Testing
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Children's Hospital of Philadelphia
Infant, Preterm
Evaluation of Safety and Efficacy of Remifentanil in Pediatric Population
The purpose of this study is to evaluate safety and efficacy of continuous infusion of remifentanil in preterm infant with mechanical ventilator for control of procedural pain using two different dosage of remifentanil.
- Trial name
- NCT01477892
- Testing
- low dose remifentanil
- Where
- South Korea
- Volunteers
- 14 people
- Sponsor
- Seoul National University Hospital
Suicidal Ideation
Validation of the French Version of Ask Suicide-Screening Questions (ASQ) in Adolescents Managed in Pediatric Emergency Unit
The ASQ-Fr study aims at validating the French version of Ask Suicide-Screening Questions composed of 5 items in adolescents managed in pediatric emergency department.
- Trial name
- ASQ-Fr (NCT02900989)
- Testing
- Suicide screening
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Metabolic Dysfunction Associated Steatotic Liver Disease, Non-Alcoholic Fatty Liver Disease (NAFLD)
Non-Invasive Diagnostic Tests for MASLD in Pediatric Population
This study aims to test the utility of Velacur ultrasound as a non-invasive, rapid, point of care diagnostic tool for detecting the presence and amount of hepatic steatosis in children and adolescents aged 2 - 20 years.
- Trial name
- NCT06218589
- Testing
- Velacur, MRI, Blood sample collection for biomarkers
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Pediatric Chronic Pain
Yoga-CBT Group Intervention for Adolescents With Chronic Pain and Their Caregivers
Clinical symptoms that are often found to be comorbid with pediatric chronic pain include anxiety, depression as well as increased stress, obesity, and decreased physical conditioning.
- Trial name
- NCT04331236
- Testing
- Cognitive Behavioral Therapy, Yoga
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Children's Hospital of Philadelphia
Pediatric Kidney Transplantation
Model-Informed Precision Dosing of Tacrolimus in Pediatric Kidney Transplantation
The purpose of this study is to develop a novel and applicable dosing algorithm that helps support the clinical decision to achieve tacrolimus levels within the optimal immunosuppression range despite sparse sampling in routine…
- Trial name
- NCT07549230
- Volunteers
- 130 people
- Sponsor
- Helwan University
Depression, Bipolar I Disorder
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States.
- Trial name
- 3112 Ped BPD (NCT04777357)
- Testing
- Cariprazine
- Where
- 81 sites in United States, Puerto Rico and 1 more
- Volunteers
- 380 people
- Sponsor
- AbbVie
Meningitis Enterovirus
Characterization of Cytokines Expression During Enterovirus Meningitis in Paediatric Populations.
Enteroviruses (EV) are the most frequent cause of acute meningitis in the paediatric population. Detection of enterovirus in cerebrospinal fluid (CSF) specimens by Polymerase Chain Reaction (PCR) is the gold standard diagnostic…
- Trial name
- Bledi-Cytokine (NCT04711876)
- Testing
- Cytokine level in blood and CSF
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand