Clinical trials: Pediatric Pulmonary Disease
Chronic Kidney Disease 5D, Chronic Kidney Disease 5T
Humoral and Cellular İmmune Response to SARS-CoV-2 mRNA BNT162b2 Vaccine in Children With Chronic Kidney Diseases
Coronavirus 2019 (COVID-19) infection is associated with higher morbidity and mortality in adult patients on dialysis, and kidney transplant recipients (KTRs).
- Trial name
- NCT05465863
- Testing
- SARS-CoV-2 mRNA BNT162b2 vaccine (Pfizer-BioNTech®)
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Ventricular Septal Defect, Atrioventricular Septal Defect
A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects
This is a randomized, double-blind, placebo controlled, multicenter study to compare the efficacy and safety of L-citrulline versus placebo in patients undergoing surgery for congenital heart defects.
- Conditions
- Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
- Trial name
- NCT05253209
- Testing
- L-citrulline, Plasmalyte A
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Sars-CoV-2 Infection, Lung Fibrosis
Low-field Magnetic Resonance Imaging of Pediatric COVID-19
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) is a new coronavirus and identified causative agent of COVID-19 disease. They predominantly cause mild colds but can sometimes cause severe pneumonia.
- Conditions
- Sars-CoV-2 Infection, Lung Fibrosis, Covid19
- Trial name
- DECRYPT (NCT04990531)
- Testing
- Low-field magnetic resonance imaging, Blood sample
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
The Frequency of ER Visits in Asthmatic Children
Asthma Education and Emergency Department Visits by Asthmatic Children
This study will be conducted to evaluate the effects of an educational asthma program on the frequency of emergency department visits and identifying factors associated with frequent emergency department visits by asthmatic…
- Trial name
- NCT05068986
- Testing
- Asthma education
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Asthma
Initiation of Chronic Asthma Care Regimens in the Pediatric Emergency Department
Hypothesis: Initiating chronic management treatment plans in conjunction with an asthma educational intervention in the pediatric Emergency Department (ED) with anti-inflammatory medication will result in an improvement of ED…
- Trial name
- IRUSBUPR0045 (NCT00388739)
- Testing
- Intervention: Budesonide, Usual care: albuterol + systemic steroids
- Where
- United States
- Sponsor
- Baylor College of Medicine
Pneumonia
Bubble Continuous Positive Airway Pressure for Children With Severe Pneumonia in Mali, Africa
This study is being conducted in Mali, Africa. Pneumonia is a respiratory infection of the lungs caused by bacteria or virus. Some children can develop signs of severe pneumonia and as a result, have difficulty breathing and low…
- Trial name
- NCT03944551
- Testing
- Bubble CPAP, Standard Therapy
- Where
- Mali
- Volunteers
- 13 people
- Sponsor
- University of Maryland, Baltimore
Asthma
Use of fenoTRACK Device for Monitoring Changes of Fractional Exhaled Nitric Oxide (FeNO) in Uncontrolled Asthma Subjects and Controlled Asthma Subjects
This study incorporates objectives directed at two subject cohorts: 1. Uncontrolled Adult and Pediatric Asthma Subjects: To demonstrate a statistically significant and clinically meaningful decline in Point Of Care (POC) FeNO as…
- Trial name
- NCT07228026
- Testing
- fenoTRACK Device
- Where
- 13 sites in United States
- Volunteers
- 160 people
- Sponsor
- Biometry Inc
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia
To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in pediatric patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have demonstrated severe or life-threatening…
- Trial name
- NCT00002317
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Sponsor
- U.S. Bioscience
Langerhans Cell Histiocytosis (LCH)
Luvometinib in Pediatric SS-LCH With Special-site Single/Multifocal Bone Lesions
Langerhans cell histiocytosis (LCH) is the most common type of histiocytic disorder in children, affecting about 2.6 to 8.9 out of every million kids each year.
- Trial name
- NCT07371182
- Testing
- Luvometinib
- Where
- 11 sites in China
- Volunteers
- 62 people
- Sponsor
- West China Second University Hospital
COVID-19
Serology and Other Immunologic Response Tests in the Diagnosis of COVID-19 in Pediatrics
Despite the SARS-CoV-2 virus being present worldwide, and although it is now clear that children are affected by the disease with milder symptoms than adults, many immunological questions, which are very relevant for Public…
- Trial name
- Covid_IMMUNO (NCT05795790)
- Where
- Italy
- Volunteers
- 249 people
- Sponsor
- IRCCS Burlo Garofolo
COVID-19 Pandemic
Covid-19 Pandemic and Pediatric Dentistry
Coronavirus (SARS-CoV-2), which emerged in Wuhan, China in 2019 and causes severe respiratory infection, poses a potential risk for dentists and patients during dental treatments.
- Trial name
- NCT06352580
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Asthma in Children
Factors Influencing Pediatric Asthma
Asthma is a chronic lung disease with serious morbidity and potential mortality. Multiple physiologic, environmental and social conditions impact the prevalence and severity of asthma.
- Trial name
- FIPA (NCT03302962)
- Testing
- Intensive Asthma Education
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Missouri Breaks Industries Research, Inc.
COVID-19, MIS-C Associated With COVID-19
Exercise Fatigue Parameters and Endothelial Function in Pediatric Patients With a History of COVID-19 Infection or MIS-C
Acute coronavirus disease 2019 (COVID-19) infection can include cardiac and pulmonary manifestations as well as post-infectious complications such as multisystem inflammatory syndrome (MIS-C), also known as pediatric inflammatory…
- Trial name
- NCT05205642
- Testing
- Cardiopulmonary exercise test (CPET), Peripheral Arterial Tonography (PAT) using the EndoPAT™ device, Endothelin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rambam Health Care Campus
Asthma
Better Pediatric Asthma Outcomes Through Chronic Care
This 3-year, multi-site study focuses on the translation of cost-effective methods to bring a chronic care model to the care of poor, minority, inner-city children with asthma, at risk of the worst outcomes for the leading…
- Trial name
- NCT00355069
- Testing
- electronic (computer based) provider feedback tool
- Where
- United States
- Volunteers
- 548 people
- Sponsor
- UConn Health
Asthma (Diagnosis)
Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma
Acute asthma exacerbation is caused by dysregulated pulmonary inflammatory pathways such that standard treatment includes prompt administration of exogenous systemic corticosteroids (SCs), but there remains an ongoing dialogue…
- Trial name
- PATCH (NCT07455396)
- Testing
- Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Johns Hopkins All Children's Hospital
Atelectasis
Lung Recruitment Assessment With Lung Ultrasound In Pediatric Patient Scheduled For Laparoscopic Surgery
Anesthesia-induced atelectasis is a well-known entity observed in approximately 68-100% of pediatric patients undergoing general anesthesia.
- Trial name
- NCT02824146
- Testing
- Lung recruitment maneuver
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Asthma
Comparison of Vibrating Mesh Nebulizer Versus Jet Nebulizer in the Pediatric Asthma Patient
The purpose of this study is to compare clinical outcomes related to the current practice of using a jet nebulizer (JN) with aerosol mask (AM) or mouthpiece (MP) versus a vibrating mesh nebulizer (VMN) with a valved-mask (VM) or…
- Trial name
- NCT02774941
- Testing
- Jet Nebulizer, Vibrating Mesh Nebulizer
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Asthma
Magnesium Trial in Acute Asthma in Emergency Department
Despite optimal initial emergency department (ED) therapy, 50% of children with severe acute asthma have ongoing moderate-severe respiratory distress.
- Trial name
- MAGICIAN (NCT06785272)
- Testing
- magnesium sulfate, Normal Saline
- Where
- 6 sites in Canada
- Volunteers
- 192 people
- Sponsor
- Suzanne Schuh
SARS-CoV-2 Infection
Chronic Mouth Breathing and SARS-CoV-2 Positivity in the Pediatric Population
Numerous non-scientific articles on the internet assert the significance of nasal breathing in protecting against COVID-19. Although nasal breathing is anticipated to result in a reduced intake of bioparticles when compared to…
- Trial name
- BREATH-COV (NCT07063134)
- Where
- Turkey (Türkiye)
- Volunteers
- 173 people
- Sponsor
- Dokuz Eylul University
Chronic Suppurative Lung Disease, Protracted Bacterial Bronchitis
Digital Physiotherapy for Pediatric Chronic Suppurative Lung Diseases
This is a prospective, single-center, two-arm (1:1), assessor-blinded, randomized controlled clinical trial that will be conducted in collaboration with the outpatient clinic of the third Pediatric Pulmonology Unit, "Attikon"…
- Conditions
- Chronic Suppurative Lung Disease, Protracted Bacterial Bronchitis, Primary Ciliary Dyskinesia (PCD), Non Cystic Fibrosis Bronchiectasis
- Trial name
- NCT07376187
- Testing
- Videoconferencing (Vsee platform), Specially designed website (FysΑΩ)
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- University of Thessaly