Clinical trials: Pediatric Respiratory Diseases
Hand Eczema, Hand Dermatitis
Consequences of Intensified Handwash and Hand Disinfection Among Children During the COVID19 Pandemic
During the COVID-19 pandemic after reopening of the country, school, kindergarten and daycare, children have been obligated to do frequent handwash.
- Conditions
- Hand Eczema, Hand Dermatitis, Covid19
- Trial name
- NCT04375410
- Where
- Denmark
- Volunteers
- 6,273 people
- Sponsor
- Regionshospital Nordjylland
Asthma
Montelukast Added to Standard Therapy for Acute Asthma in Children Age 6-14 Years
Oral montelukast is helpful in chronic asthma. The purpose of this pediatric study was to investigate whether the addition of oral montelukast to standard therapy for acute asthma exacerbations results in further improvement in…
- Trial name
- NCT00353184
- Testing
- Montelukast 5-mg orally added to standard therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Moderate Respiratory Distress, Severe Respiratory Distress
High Flow Nasal Oxygen Therapy an Implementation Study in Pediatric Wards
The purpose of this study is to prospectively evaluate the process of implementing HFNO in several MSF projects, varying according to geographical and programmatic contexts, population, health structures, human resources, and…
- Trial name
- HFNO (NCT06715423)
- Where
- Afghanistan
- Volunteers
- 960 people
- Sponsor
- Epicentre
Cystic Fibrosis, Cystic Fibrosis in Children
Program Of Exercises During The Hospitalization Of Children And Adolescents With Cystic Fibrosis
The objective of this study was to evaluate the effect of a physical exercise program on the functional capacity of children and adolescents with cystic fibrosis hospitalized at the Hospital de Clínicas of Porto Alegre (HCPA)…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis in Children, Cystic Fibrosis Pulmonary Exacerbation, Cystic Fibrosis With Exacerbation
- Trial name
- NCT03273959
- Testing
- Exercise protocol
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Community-acquired Pneumonia, Skin Infection
Improving Short Course Treatment for Common Pediatric Infections
Randomized quality improvement trial to improve the proportion of cases of community-acquired pneumonia (CAP) treated with no more than 5 days of antibiotics the proportion of cases of skin and soft tissue infections (SSTI)…
- Trial name
- NCT06087809
- Testing
- Education and feedback, Clinical decision support
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Boston Children's Hospital
Acute Lung Injury, Acute Respiratory Distress Syndrome
Effects and Safety of Infusion of Low-Doses of Methylprednisolone in Early ALI and ARDS in Children
The purpose of this study is to investigate the effects of prolonged low-dose methylprednisolone infusion on pulmonary function (LIS and ventilation-free days), extra pulmonary organ function (PMODS score), inflammatory markers …
- Trial name
- PEDALI (NCT01757899)
- Testing
- Methylprednisolone Arm, Sterile Saline Arm
- Where
- Brazil
- Sponsor
- Universidade Federal do Rio de Janeiro
Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia
Altitude and Outcomes in Pediatric ARDS: A Multicenter Study
This multicenter observational study will evaluate the association between geographic altitude, availability of critical care resources, and clinical outcomes in children with pediatric acute respiratory distress syndrome…
- Conditions
- Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia, High Altitude Effects
- Trial name
- LARed-ALT (NCT07193771)
- Testing
- Geographic Altitude
- Where
- 20 sites in Bolivia, Chile and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Latin American Pediatric Collaborative Network
Asthma in Children, Pollution; Exposure
AIM to Improve Asthma: Airflow Improvements During Meal-Prep
The investigators propose a pilot trial of kitchen ventilation in the homes of children using a youth engaged research strategy.
- Trial name
- AIM (NCT04464720)
- Testing
- Cooking Ventilation Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, Berkeley
Respiratory Infection
Unclogging the Pediatric Emergency Room: Impact of Rapid Viral Diagnostics
Acute respiratory tract infections are among the most common problems of childhood, particularly among infants and children younger than 3 years, and account for most antibiotic prescriptions to children.
- Trial name
- NCT00278759
- Testing
- Nasopharyngeal washing for viral antigen detection by immunofluorescence initiated early in ED visit.
- Where
- Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Atelectasis
Continuous Positive Airway Pressure Decreased Lung Collapse During General Anesthesia Induction in Pediatric Patients
Anesthesia-induced atelectasis is a well-known entity observed in approximately 68-100% of pediatric patients undergoing general anesthesia.
- Trial name
- NCT03461770
- Testing
- CPAP
- Where
- Argentina
- Volunteers
- 42 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
COVID19, Coronavirus Infection
Convalescent Plasma Collection and Treatment in Pediatrics and Adults
This is a prospective study, using plasma to help fight off infections of those suffering from COVID-19 in accordance with collection guidelines for plasma and FDA IND requirements.
- Conditions
- COVID19, Coronavirus Infection, Coronavirus, Virus Diseases
- Trial name
- NCT04376034
- Testing
- Convalescent Plasma
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- West Virginia University
Pulmonary Hypertension
Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension
Pulmonary hypertension (PH) is a consequence of an increase in pulmonary vascular resistance (PVR), pulmonary blood flow, pulmonary venous pressure, or a combination of these elements.
- Trial name
- NCT02595541
- Testing
- milrinone, Sildenafil
- Volunteers
- 30 people
- Sponsor
- Assiut University
Acute Kidney Injury, Covid19
Renal Involvement in Hospitalized Children With COVID-19
Covid-19 is an important human and animal pathogen, it mostly causes respiratory and gastrointestinal symptoms. Clinical features range from a common cold to severe diseases such as severe acute respiratory distress syndrome…
- Conditions
- Acute Kidney Injury, Covid19, Renal Dysfunction, Coronavirus Infection
- Trial name
- RIHCC (NCT04788394)
- Testing
- data review, data comparing
- Where
- Qatar
- Volunteers
- 400 people
- Sponsor
- Hamad Medical Corporation
Ventilator Associated Pneumonia ( VAP)
Impact of Oral Care on Ventilator Associated Pneumonia
The goal of this clinical trial was to find out whether cleaning the mouths of children in the Pediatric Intensive Care Unit (PICU) with toothbrushing and chlorhexidine lowers the chance of getting lung infections in patients on…
- Trial name
- OH-VAP (NCT07287566)
- Testing
- Toothbrushing + Chlorhexidine, Routine oral care + Chlorohexidine
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Ain Shams University
Obstructive Sleep Apnea
Rapid Maxillary Expansion for Residual Pediatric
Randomized Controlled Trial comparing Rapid Maxillary Expansion with Standard Clinical Practice in patients with residual pediatric Obstructive Sleep Apnea Syndrome after adenotonsillectomy.
- Trial name
- ERMES (NCT02947464)
- Testing
- Standard clinical practice, Standard clinical practice + Rapid Maxillary Expansion
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Asthma in Children, Status Asthmaticus
BPAP in Pediatric Asthma Pilot Study
The investigators aim to study the effect and safety of bilevel positive airway pressure (BPAP) in children with moderate to severe asthma exacerbations - by examining the effects of early initiation of BPAP in pediatric patients…
- Trial name
- NCT04656587
- Testing
- Philips Respironics V60 Non-invasive ventilator, BPAP, Standard Therapy
- Sponsor
- Columbia University
Bronchiolitis
Heliox-Driven Racemic Epinephrine in Treatment of Bronchiolitis in Pediatric ED Patients
The purpose of this study is to assess whether children with moderate to severe bronchiolitis treated with standard racemic epinephrine therapy via 70:30 helium-oxygen (heliox) driven nebulization will have improvements in…
- Trial name
- NCT00116584
- Testing
- heliox, oxygen
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Diabetes, Chronic Kidney Disease
Vaccination Coverage and Level of Protection in Patients at Risk
The purpose of this study is to determine 1. vaccination coverage of recommended vaccines (routine childhood vaccines and vaccines against seasonal flu and pneumococci) in children with chronic diseases (allergy, cystic fibrosis…
- Conditions
- Diabetes, Chronic Kidney Disease, Allergy, Cystic Fibrosis
- Trial name
- NCT03820752
- Where
- Belgium
- Volunteers
- 2,179 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rhinitis
Phenylephrine Pediatric Pharmacokinetic Study
To characterize the pharmacokinetics of phenylephrine in two pediatric populations: children, ages 2 to <12 years, and adolescents, ages 12 to <18 years.
- Trial name
- NCT00762567
- Testing
- phenylephrine HCl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Cystic Fibrosis
A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance Index
The Lung Clearance Index (LCI) is a non invasive measure of lung function that is more sensitive than FEV1. It can be used to measure lung function in children younger than 6 years of age.
- Trial name
- NCT02276898
- Testing
- Hypertonic Saline 7%
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children