Clinical trials: Pediatric Sedation
Congenital Heart Disease, Sedated for Cardiac Catheterization
Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions
Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions.
- Trial name
- NCT01501786
- Testing
- control, Ket10, Ket20
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Ibaraki Children's Hospital
Pediatric Procedural Sedation
Intranasal Dexmedetomidine vs. Oral Chloral Hydrate for Pediatric Orthopedic Procedural Sedation
This prospective randomized controlled study will compare the effectiveness and safety of intranasal dexmedetomidine with oral chloral hydrate for procedural sedation in children undergoing painful orthopedic manipulation.
- Trial name
- NCT07768566
- Testing
- Dexmedetomidine, Chloral Hydrate
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Childrens Hospital
Prolonged Sedation
Dexmedetomidine for Prolonged Sedation in PICUs
Sedation management of the critically ill patients is still a challenge for the pediatric intensivists. Worldwide the most common sedation approach includes the concomitant use of opioids and benzodiazepines.
- Trial name
- PROSDEX (NCT03760978)
- Testing
- Dexmedetomidine
- Where
- 9 sites in Italy
- Volunteers
- 163 people
- Sponsor
- Azienda Ospedaliera di Padova
Respiratory Insufficiency
Effect of High Flow Nasal Cannula vs. Standard Care on Respiratory Stability in Pediatric Procedural Sedation
Procedural sedation is an established and safe intervention and is widely used in diagnostic and therapeutic procedures for pediatric patients.
- Trial name
- HiFiPPS (NCT02930525)
- Testing
- High Flow nasal cannula, Standard respiratory care
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Freiburg
Anxiety
High-Concentration Nitrous Oxide for Dental Procedural Sedation in Children
The use of nitrous oxide as a sedative agent is very common in pediatric dentistry. In concentrations up to 50% it is considered as mild sedation and it is very safe.
- Trial name
- NCT02886351
- Testing
- Nitrous Oxide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Pain, Procedural, Procedural Anxiety
Evaluating the Feasibility of VR for Pediatric Renal Biopsies
The purpose of this study is to assess the use of virtual reality (VR) as an adjunct or alternative to pharmacologic sedation in pediatric patients undergoing renal biopsy.
- Conditions
- Pain, Procedural, Procedural Anxiety, Sedation Complication
- Trial name
- NCT05267704
- Testing
- Oculus Go Virtual Reality Headset
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypoxemia, Pneumonia
Effect of High-Flow Nasal Cannula Oxygen Therapy on Hypoxemia in Pediatric Sedated Bronchoscopy
Due to children's lower oxygen reserves and higher oxygen consumption, sedation can easily lead to respiratory adverse events such as hypoxemia.
- Conditions
- Hypoxemia, Pneumonia, Pulmonary Neoplasm
- Trial name
- NCT07563075
- Testing
- High-flow nasal cannula, Regular Nasal Cannula
- Where
- 4 sites in China
- Volunteers
- 430 people
- Sponsor
- Zhejiang University
Pediatric Solid Tumor, Pediatric Brain Tumor
Effects of Music and Maternal Voice on Sedation Depth and Sedative Use During Pediatric Magnetic Resonance Imaging.
To evaluate the effects of music and maternal voice in children on sedation depth and sedative use during pediatric magnetic resonance imaging.
- Conditions
- Pediatric Solid Tumor, Pediatric Brain Tumor, Pediatric Cancer
- Trial name
- NCT04944875
- Testing
- Group headphone, Group music, Group maternal voice
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Respiratory Syncytial Virus Infections
Music Therapy With Intubated and Sedated Pediatric Patients
The study is a randomized controlled trial of pediatric patients ages birth to two years of age who are mechanically ventilated and sedated as a result of a respiratory virus.
- Trial name
- NCT03629145
- Testing
- Live Music Therapy, Recorded Music Therapy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Children's Healthcare of Atlanta
Dental Caries
Isolite and Dental Treatment Under Conscious Sedation
Hypothesis The use of Isolite® system does not produce upper airway obstruction in the pediatric population during dental treatment with conscious sedation.
- Trial name
- NCT01683851
- Testing
- Isolite System
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pediatric, Gastroscopy
Effect of Esketamine on 95% Induction Dose of Remimazolam
As an invasive operation, gastroscopy will cause children's nervousness, anxiety and uncooperative behavior, and even lead to the risk of bleeding and perforation, which will also affect the accuracy of the examination…
- Conditions
- Pediatric, Gastroscopy, ED95, Sedation
- Trial name
- EEIDR (NCT06303037)
- Testing
- Remimazolam besylate and low-dose Esketamine, Remimazolam besylate and Medium dose Esketamine
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Stress, Job
Stress Level Among Dentists in Performing Treatment
Purpose: To evaluate the stress levels of dentists working under clinical, deep sedation, or general anaesthesia. Methods: Blood pressure (Systolic, Diastolic blood pressure), Pulse value, O2 saturations were measured, and saliva…
- Trial name
- NCT05394480
- Testing
- Blood pressure (Systolic, Diastolic), Pulse value, O2 saturations were measured.
- Where
- Turkey (Türkiye)
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
ICU Sedation
Study of DA-9501 In Pediatric Subjects In The Intensive Care Unit
To evaluate the efficacy, safety, and pharmacokinetics of dexmedetomidine given as continuous IV infusion in pediatric subjects [≥ 45 weeks CGA (corrected gestational age) to <17 years old] requiring sedation under intensive care…
- Trial name
- NCT02757625
- Testing
- Dexmedetomidine hydrochloride
- Where
- 12 sites in Japan
- Volunteers
- 63 people
- Sponsor
- Pfizer
Orofacial Clefts, Cleft Lip and Palate
Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery
This prospective, randomized study is designed to compare the efficacy and safety of three sedative-analgesic agents-intramuscular ketamine, intranasal nalbuphine, and intranasal dexmedetomidine-for procedural sedation in…
- Conditions
- Orofacial Clefts, Cleft Lip and Palate, Alveolar Ridge Defect
- Trial name
- KID-CLEFT (NCT07340008)
- Testing
- ketamine, Nalbuphine, Dexmedetomidine
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Dexmedetomidine, Sedation
Intranasal Dexmedetomidine Sedation in Children for Non-painful Procedures
Specific Aim 1: To describe the adequacy of sedation associated with different regimens of IN DEX in children undergoing non-painful procedures.
- Trial name
- NCT03220880
- Testing
- Intranasal dexmedetomidine
- Where
- 8 sites in United States
- Volunteers
- 578 people
- Sponsor
- Columbia University
Withdrawal Syndrome
Efficacy and Safety of Dexmedetomidine During Weaning From Analgesia and Sedation in PICU (TIP-15-01)
This interventional study evaluates the efficacy of dexmedetomidine during weaning from analgesic and sedative drugs in reducing the occurrence of the withdrawal syndrome in PICU.
- Trial name
- TIP-15-01 (NCT03645603)
- Testing
- Dexmedetomidine
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Procedural Sedation and Analgesia During Bone Marrow Aspiration and Biopsy
Dexmedetomidine Versus Midazolam Added to Ketamine in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy
Group I :The patients will receive midazolam intravenously (i.v.) in a dose of 0.05 mg/kg diluted by 50ml saline over 10 minutes using syringe pump plus 1 mg/kg ketamine (iv).
- Trial name
- NCT03647579
- Testing
- midazolam intravenous infusion of 0.05 mg/kg plus 1 mg/kg ketamine, Dexmedetomidine intravenous infusion of 2mic/kg plus 1 mg/kg ketamine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Monitored Anesthesia Care, Respiratory Monitoring
Importance of Integrated Pulmonary Index in Pediatric Endoscopy
Integrated Pulmonary Index (IPI) is a tool that provides numerical values on a scale of 1-10 based on physiological parameters such as peripheral oxygen saturation (SpO2), pulse rate, respiratory rate, end-tidal carbon dioxide…
- Trial name
- NCT05137574
- Testing
- Integrated Pulmonary Index (IPI) monitoring, propofol, ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Multiparametric Magnetic Resonance Imaging, Propofol Adverse Reaction
Safety Evaluation of Propofol Sedation for Magnetic Resonance Imaging in Pediatric Patients
Propofol is often used for sedation in children undergoing magnetic resonance imaging. The investigators will perform a chart review of 4 month of activity (about 100 cases) and review the incidence and severity of adverse events…
- Conditions
- Multiparametric Magnetic Resonance Imaging, Propofol Adverse Reaction, Sedation Complication, Anesthesia; Adverse Effect
- Trial name
- NCT04455776
- Testing
- Propofol
- Where
- Belgium
- Volunteers
- 99 people
- Sponsor
- Brugmann University Hospital
Sedation
Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural Sedation in Children
In Korea, oral chloral hydrate is still widely used for pediatric procedural sedation. The primary objective of the study is to evaluate the effect of intranasal dexmedetomidine (2mcg/kg) and ketamine (3mg/kg) on the…
- Trial name
- NCT04820205
- Testing
- Intranasal dexmedetomidine and ketamine, Oral chloral hydrate
- Where
- South Korea
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital