Clinical trials: Pediatric Sedation
Adverse Event
Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure
Emergence agitation is the most common reason for post-anesthesia care unit delay. Sevoflurane is used frequently inhalational anaesthetic agent to provide pediatric anaesthesia because of the nonirritant nature.
- Trial name
- NCT05321160
- Testing
- Esketamine, Sevoflurane
- Where
- China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Magnetic Resonance Imaging Contrast Media Adverse Reaction, Sedation Complication
Non-operating Room Anesthesia Experiences in Pediatric Magnetic Resonance Imaging Cases
In recent years, out patient anesthesia applications have been increasing for diagnostic and interventional procedures for pediatric patients.
- Trial name
- NCT05423821
- Testing
- Anesthesia efficacy in patients undergoing MRI
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Yunus Emre
Pediatric, Sedation
Nebulized Dexmedetomidine as a Premedication for Gastrointestinal Endoscopy in Pediatric Patients
This study aims to demonstrate that the application of nebulized dexmedetomidine to patients during pediatric upper gastrointestinal endoscopic procedures will significantly reduce the gag reflex and enhance both patient and…
- Trial name
- NCT06218797
- Testing
- a routine sedation protocol, Nebulized with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ondokuz Mayıs University
Pediatric, ED95
The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction
Due to the incomplete development of systems and low pain thresholds in the pediatric population, good general anesthesia is required during the perioperative period to ensure the smooth progress of the surgery.Propofol is often…
- Conditions
- Pediatric, ED95, Sedation, General Anesthesia
- Trial name
- NCT06061159
- Testing
- Remimazolam besylate
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sedation, Preoperative Anxiety Experienced by the Pediatric Patient
Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.
This study aims to compare intranasal dexmedetomidine versus intranasal ketamine as a premedication in children undergoing surgery in our population.
- Conditions
- Sedation, Preoperative Anxiety Experienced by the Pediatric Patient, Anxiolytic Effect, Sedation and Analgesia
- Trial name
- DREAM-Kids (NCT07180095)
- Testing
- Intranasal dexmedetomidine, Intranasal ketamine
- Volunteers
- 60 people
- Sponsor
- Liaquat National Hospital & Medical College
Early Childhood Caries
Midazolam Efficacy for Sedating Preschoolers Undergoing Dental Treatment
Evaluation of oral midazolam to improve children's behavior and reduces the stress and anxiety during dental treatment
- Trial name
- Pedsed-I (NCT01795222)
- Testing
- Midazolam
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Universidade Federal de Goias
Child Behavior, Dental Caries
Midazolam and Ketamine Effect Administered Through the Nose for Sedation of Children for Dental Treatment
Randomised clinical trial to test the efficacy, safety and cost-effectiveness of sedatives; masked, controlled, parallel design with three arms, phase 4.
- Trial name
- NASO (NCT02447289)
- Testing
- Intranasal ketamine, Oral ketamine, Intranasal midazolam
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Nitrous Oxide Inhalation Sedation
Comparison of the Silhouette and Porter Brown Systems Used in Inhalation Sedation
This is a randomised non-blinded controlled clinical trial, which involves the measurement of efficiency and acceptability of the Silhouette Mask system and compares it with the Porter Brown Mask system used for Inhalation…
- Trial name
- NCT04734509
- Testing
- Silhouette breathing system
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Deep Sedation, Intensive Care Pediatric
Pharmacokinetic Analysis of Midazolam and Fentanyl in Pediatric Patients With Long-term Analgosedation
Pharmacokinetic monitoring of midazolam, it's active metabolite and fentanyl in pediatric patients with long-term analgosedation will be performed.
- Trial name
- Morpheus (NCT02302391)
- Testing
- PK analysis
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mechanical Ventilation Complication
Reduce Pediatric Sedation to Reduce Mechanical Ventilation Complication in ICU
Mechanical ventilation is a common procedure used in pediatric intensive care units (ICU). Its use requires almost always the establishment of a sedation.
- Trial name
- PEDIASED (NCT02040168)
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Nantes University Hospital
Sedation, Pain
Phase II Pharmacokinetic and Pharmacodynamic Study of DEX in Subjects Aged 12 Months Through <24 Months
The purpose of this study is to investigate the pharmacokinetic, pharmacodynamic, and safety of dexmedetomidine at 2 different dose levels in pediatric subjects, aged 12 months through <24 months, administered as an intravenous…
- Trial name
- NCT01378988
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
Prolonged Sedation
Dexmedetomidine for Prolonged Sedation in PICUs
Sedation management of the critically ill patients is still a challenge for the pediatric intensivists. Worldwide the most common sedation approach includes the concomitant use of opioids and benzodiazepines.
- Trial name
- PROSDEX (NCT03760978)
- Testing
- Dexmedetomidine
- Where
- 9 sites in Italy
- Volunteers
- 163 people
- Sponsor
- Azienda Ospedaliera di Padova
Anxiety, Separation
A Comparison of Two Doses of Intranasal Dexmedetomidine for Premedication in Children
The purpose of the study is to determine if 4mcg/kg of intranasal dexmedetomidine is better than 2mcg/kg in successfully sedating a child prior to induction of anesthesia.
- Trial name
- NCT02459509
- Testing
- Dexmedetomidine
- Where
- Hong Kong
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pediatric Acute Lung Injury
Pharmacologic Impact on Sedation Assessments
PISA is an ancillary study to the NIH funded clinical RESTORE Trial (U01 HL086622). This study will provide data that may allow for improved dosing recommendations in this critically ill population of children.
- Trial name
- PISA (NCT01105663)
- Testing
- Pharmacokinetic Sampling and pharmacogenetic analysis
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Children's Hospital of Philadelphia
Anxiety State, Pediatric ALL
Anxiolytic Effects of Lavender and Orange Oil
The aim of this study is to determine the possible anxiety reducing effects of lavender oil and orange oil on parents with children receiving dental care under sedation during perioperative wait.
- Conditions
- Anxiety State, Pediatric ALL, Dental Anxiety, Oil; Inhalation
- Trial name
- NCT04079309
- Testing
- Lavender/Orange
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara University
Sedation
Sedation During Pediatric Diagnostic Gastrointestinal Endoscopy Gastrointestinal Endoscopy
comparison between propofol-fentanyl and propofol-ketamine for sedation in pediatric diagnostic gastrointestinal endoscopy.
- Trial name
- NCT03235609
- Testing
- Fentanyl, Ketamine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Dental Caries
Isolite and Dental Treatment Under Conscious Sedation
Hypothesis The use of Isolite® system does not produce upper airway obstruction in the pediatric population during dental treatment with conscious sedation.
- Trial name
- NCT01683851
- Testing
- Isolite System
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Procedural Sedation and Analgesia During Bone Marrow Aspiration and Biopsy
Dexmedetomidine Versus Midazolam Added to Ketamine in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy
Group I :The patients will receive midazolam intravenously (i.v.) in a dose of 0.05 mg/kg diluted by 50ml saline over 10 minutes using syringe pump plus 1 mg/kg ketamine (iv).
- Trial name
- NCT03647579
- Testing
- midazolam intravenous infusion of 0.05 mg/kg plus 1 mg/kg ketamine, Dexmedetomidine intravenous infusion of 2mic/kg plus 1 mg/kg ketamine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Leukemia, Lymphoma
Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma
The hypothesis of the study is that propofol-fentanyl sedation for lumbar punctures in children with acute leukemia/lymphoma results in fewer adverse events than propofol sedation alone.
- Trial name
- NCT00214370
- Testing
- Propofol-Fentanyl, Propofol alone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison