Clinical trials: Pediatrics Cancer
Breakthrough Pain, Palliative Medicine
Paediatric Breakthrough Pain Assessment
Many children and young people with life-limiting and life-threatening illnesses get sudden bursts of pain called breakthrough pain. At the moment, there aren't any good ways to measure this pain in children and young people.
- Conditions
- Breakthrough Pain, Palliative Medicine, Oncology Pain, Pediatric ALL
- Trial name
- BEACON (NCT06790719)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Hematologic Diseases, Oncology Problem
Clinical Validation of a Dried Blood Spot Method for Analysis of Immunosuppressives and Antifungals in Pediatrics
This is a clincial validation study of a dried blood spot (DBS) method for the analysis of immunosuppressive and antifungal agents currently subject of therapeutic drug monitoring (TDM) in a pediatric population.
- Conditions
- Hematologic Diseases, Oncology Problem, Kidney Diseases, Transplantation Infection
- Trial name
- PROTECT (NCT02329808)
- Testing
- blood drawing
- Where
- Netherlands
- Volunteers
- 93 people
- Sponsor
- Radboud University Medical Center
Brain Cancer
Controlling Coordination After Childhood Cerebellar Cancer, a Pilot Study
Posterior fossa tumours (PFT) account for 2/3 of childhood brain cancers. They can be highly malignant requiring combined chemotherapy and radiotherapy post-surgery for a >50% chance of cure.
- Trial name
- 5C-pilot (NCT04501731)
- Testing
- Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Imaging (MRI), Motor assessment
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Locally Resectable Pediatrics Tumors
CEB-01 in Pediatrics With Locally Resectable Abdominal Tumors
The CEB-01 implant is a membrane containing SN-38, the active metabolite of irinotecan, an already authorized chemotherapeutic agent.
- Trial name
- NCT06986811
- Testing
- Standard surgery, CEB-01
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- CEBIOTEX
Burns, Pediatric ALL
Telemedicine Optimized Burn Intervention
Because burn patients and their caregivers often live long distances from regional burn centers, access to expert burn care is limited, resulting in a negative effect on adherence to treatment and a higher risk of wound…
- Trial name
- TOBI (NCT05019144)
- Testing
- Face-to-face burn care, Telemedicine enhanced burn care
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Medical University of South Carolina
Acute Myeloid Leukemia (AML) in Remission, Stem Cell Transplantation
Studying Conditioning Regimen In Pediatric Transplantation - AML , SCRIPT-AML
It is a randomized phase 3 study comparing two conditioning regimens in children with Acute Myeloid Leukemia, AML, undergoing allogenic stem cell transplantation.
- Trial name
- SCRIPT-AML (NCT05477589)
- Testing
- busulfan, cyclophosphamide and melphalan, BuCyMel, clofarabine, fludarabine and busulfan, CloFluBu
- Where
- 17 sites in Belgium, Denmark and 8 more
- Volunteers
- 170 people
- Sponsor
- Vastra Gotaland Region
Stem Cell Transplant, Stem Cell Transplantation
Fertility Protection for Children, Adolescents and Young Adults
This study focuses on improving fertility preservation and long-term care for children, adolescents, and young adults (CAYA) undergoing cancer treatments or stem cell transplantation.
- Conditions
- Stem Cell Transplant, Stem Cell Transplantation, Oncological Outcomes, Oncological Patients
- Trial name
- FeProCAYA (NCT06692868)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Ulm
Brain Tumor
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type2.0/2.1 in combination with Doxorubicin therapy for the treatment of DIPG in pediatric…
- Trial name
- NCT05630209
- Testing
- Exablate, Doxorubicin
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- InSightec
Diffuse Intrinsic Pontine Glioma
Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma
The aim of the study is to determine the safety of Cilengitide in combination with radiation therapy.
- Trial name
- CILENT (NCT01165333)
- Testing
- Cilengitide dose escalation, Cilengitide, Concomitant radiotherapy
- Where
- 9 sites in France
- Volunteers
- 32 people
- Sponsor
- Centre Oscar Lambret
Fever, Neutropenia
Fever and Neutropenia in Pediatric Oncology Patients
It is possible to distinguish between pediatric oncology patients who are at high or low risk for serious infection during periods of fever and treatment related neutropenia based on clinical parameters.
- Trial name
- NCT03768869
- Testing
- Low Risk: Oupatient Management, Low Risk: Inpatient Management, High Risk: Inpatient Management
- Where
- United States
- Sponsor
- University of Colorado, Denver
Wilms Tumor, Renal Cancer
Nephrogreen. Appearances of Exvivo Renal Tumours Under Near-infrared
Indocyanine Green (ICG) is a dye which fluoresces under near-infrared (NIR) light. It has been used for several applications in adult surgery.
- Trial name
- Nephrogreen (NCT05735977)
- Testing
- Indocyanine Green (ICG)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Cancer
Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations
This was a 4-part (Part A, Part B, Part C and Part D), Phase I/IIa, multi-center, open label, study in pediatric subjects with refractory or recurrent tumors.
- Trial name
- NCT02124772
- Testing
- Trametinib, Dabrafenib
- Where
- 16 sites in United States, Australia and 3 more
- Volunteers
- 139 people
- Sponsor
- Novartis Pharmaceuticals
Brain Tumor, Primary
Neurofeedback and Cognitive Training for PBTS
Brief Summary of the Study: This study is a prospective, randomized, sham-controlled, triple-blind trial investigating whether combining individualized alpha neurofeedback (NF) with cognitive training (Cogmed) can improve…
- Trial name
- NCT07085494
- Testing
- neurofeedback, Cognitive Training
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Neuroblastoma, Rhabdomyosarcoma
Study to Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors
The purpose of this study is to find the safe dose of nab-paclitaxel in children with solid tumors, and to see if it works to treat these solid tumors in children and young adults (in Phase 1 ≤ 18 years old and in Phase 2 ≤ 24…
- Conditions
- Neuroblastoma, Rhabdomyosarcoma, Ewing's Sarcoma, Ewing's Tumor
- Trial name
- NCT01962103
- Testing
- nab-paclitaxel
- Where
- 20 sites in United States, Canada and 5 more
- Volunteers
- 107 people
- Sponsor
- Celgene
Pediatric Cancer
Data Collection of Normal Tissue Toxicity for Proton Therapy for Pediatrics
The goal of this research study is to collect information on the side effects of proton therapy and the details of proton treatment plans so that researchers can develop a method to predict the risk of side effects and to improve…
- Trial name
- NCT01502150
- Testing
- Data Collection, Dose Distribution Data Collection
- Where
- United States
- Volunteers
- 798 people
- Sponsor
- M.D. Anderson Cancer Center
Pediatric Oncology
Fit to Fight Childhood Cancer
The aim of the study is to investigate the influence of exercise on physical performance and psychosocial aspects in children and adolescents with cancer during and after treatment.
- Trial name
- Kolibri (NCT05867186)
- Testing
- Exercise training
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Johannes Gutenberg University Mainz
Pediatric Oncology
Exercise Training in Childhood Cancer
The purpose of this multicenter study is to evaluate a personalised and standardised exercise intervention for children and adolescents undergoing anti-cancer treatment.
- Trial name
- FORTEe (NCT05289739)
- Testing
- Exercise training
- Where
- Germany
- Volunteers
- 478 people
- Sponsor
- Johannes Gutenberg University Mainz
Quality of Life (QOL), Patient-Reported Outcome Measures (PROMs)
Validation of the EQ-5D-Y-3L and EQ-5D-Y-5L for Paediatric Patients in China
The goal of this observational study is to validate the EQ-5D-Y-3L and EQ-5D-Y-5L in measuring health-related quality of life (HRQoL) for paediatric patients with different health conditions in China.
- Conditions
- Quality of Life (QOL), Patient-Reported Outcome Measures (PROMs), Pneumonia Childhood, Neuroblastoma (NB)
- Trial name
- NCT06873672
- Where
- China
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Recurrent and Refractory Solid Tumors
Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric Solid Tumors, Including Central Nervous System Tumors
Phase 1 of this study, utilizing a rolling 6 design, will be conducted to determine a maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D), and to describe the toxicities of lenvatinib administered in combination with…
- Trial name
- NCT03245151
- Testing
- Lenvatinib, Everolimus
- Where
- 50 sites in United States, Canada
- Volunteers
- 64 people
- Sponsor
- Eisai Inc.
Neuroblastoma
Allogeneic Tumor Cell Vaccination With Oral Metronomic Cytoxan in Patients With High-Risk Neuroblastoma
Neuroblastoma is the second most common solid tumor seen in children, but causes approximately 15% of childhood cancer deaths each year.
- Trial name
- ATOMIC (NCT01192555)
- Testing
- Neuroblastoma Vaccine (unmodified SKNLP, with gene-modified SJNB-JF-IL2 and SJNB-JF-LTN neuroblastoma cells, Cytoxan
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine