Clinical trials: Pelvic Neoplasms
Rectal Cancer, Rectal Neoplasms
Exploring HIFU as a Treatment for Rectal and Other Pelvic Cancers
The hypothesis of the study is that high intensity focused ultrasound (HIFU) can be used safely to treat rectal and pelvic cancer.
- Conditions
- Rectal Cancer, Rectal Neoplasms, Pelvic Cancer, Endometrial Cancer
- Trial name
- NCT03595722
- Testing
- High Intensity Focused Ultrasound
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Malignant Neoplasms of Mesothelial and Soft Tissue, Rhabdomyosarcoma, Pelvic
Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in Children
The goal of this clinical research study is to find the highest tolerable dose of heated doxorubicin that can be given to patients during surgery with abdominal tumors. The safety of this drug will also be studied.
- Conditions
- Malignant Neoplasms of Mesothelial and Soft Tissue, Rhabdomyosarcoma, Pelvic, Rhabdomyosarcoma, Abdominal
- Trial name
- NCT03111069
- Testing
- Abdominal Surgery, Doxorubicin, Intra-Operative Radiation
- Sponsor
- M.D. Anderson Cancer Center
Ureteral Obstruction
Drainage of Malignant Extrinsic Ureteral Obstruction Using the Memokath Ureteral Stent
The purpose of this study is to evaluate the safety and efficacy of the Memokath 051 ureteral stent as a long-term temporary and minimally invasive means of providing ureteral drainage in the setting of malignant extrinsic…
- Trial name
- NCT00166361
- Testing
- Memokath 051 Ureteral Stent, JJ Stent
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Labor, Pelvic Floor Disorder
Pelvic Floor Ultrasound Before Induction of Labour and Labour Outcome
Pregnancy and vaginal birth are the main causes of pelvic floor disorders such as urinary incontinence and pelvic organ prolapse.
- Conditions
- Labor, Pelvic Floor Disorder, Labor Stage, Second, Induced Labor
- Trial name
- LEVATOR-IOL (NCT07797387)
- Testing
- Three-dimensional transperineal pelvic floor ultrasound
- Where
- Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Cancer, Diarrhea
Impact of Probiotics BIFILACT® on Diarrhea in Patients Treated With Pelvic Radiation
In this double-blinded randomized clinical trial study, investigators assessed probiotic used to prevent or delay radiation induced grade moderate to severe diarrhea with patient treated for pelvic cancer.
- Conditions
- Cancer, Diarrhea, Abdominal Pain, Quality of Life
- Trial name
- NCT01839721
- Testing
- Bifilact®
- Where
- Canada
- Volunteers
- 246 people
- Sponsor
- CHU de Quebec-Universite Laval
Rectal Cancer
Pelvic Drain After Rectal Resection for Mid-low Rectal Cancer
This RCT aims at assessing the effects of a pelvic drain after total mesorectal excision for mid-low rectal cancer on the rates of pelvic sepsis and anastomotic leaks.
- Trial name
- GECO1 (NCT04573621)
- Testing
- Pelvic drain, No pelvic drain is placed
- Where
- Spain
- Volunteers
- 518 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Recurrent Cervical Cancer, Recurrent Ovarian Epithelial Cancer
Phase I Study of Intravenous Triapine (IND # 68338) in Combination With Pelvic Radiation Therapy With or Without Weekly Intravenous Cisplatin Chemotherapy for Locally Advanced Cervical, Vaginal, or Pelvic Gynecologic Malignancies
Drugs used in chemotherapy, such as 3-AP and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Recurrent Cervical Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Vaginal Cancer, Recurrent Vulvar Cancer
- Trial name
- NCT00335998
- Testing
- triapine, laboratory biomarker analysis, external beam radiation therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Rectum Cancer
Reconstruction of the Pelvic Floor and Perineal Wound After Rectal ELAPE
A multicenter, cohort, randomized, controlled study is being conducted since the 1of September, 2023 whereby the immediate and long-term results of pelvic floor and perineal wound plastic surgery after extralevatory…
- Trial name
- NCT06066931
- Testing
- Plastic surgery of the pelvic floor and perineal wound with counter-displaced skin-subcutaneous fascial flaps after extralevatory abdominal-perineal extirpation of the rectum, Plastic surgery of the pelvic floor and perineal wound with local tissues, Plastic surgery of the pelvic floor and perineal wound with mesh endoprosthesis
- Volunteers
- 150 people
- Sponsor
- Kuban State Medical University
Prostate Cancer
Trial Comparing Radical Radiotherapy to Prostate Only VS Prostate And Pelvic Lymph Nodes in Intermediate And High Risk Prostate Cancer
This phase II randomized controlled study aims to compare the treatment results of intermediate and high risk prostate cancer patients treated with hormonal therapy and radical radiotherapy with or without pelvic lymph nodes in…
- Trial name
- NCT05285319
- Testing
- Prostate Only Radiation, Prostate and Pelvic Lymph Node Radiation
- Where
- Egypt
- Volunteers
- 82 people
- Sponsor
- Cairo University
Colo-rectal Cancer
Psychological distREsS hipEc oR pelVic Exenteration
The purpose of this study is to describe type and extent of psychological distress (adverse effects) in patients undergoing surgery for colorectal cancer with peritoneal metastases and after surgery for colorectal cancer with…
- Trial name
- PRESERVE (NCT04956107)
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 225 people
- Sponsor
- University of Aarhus
Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling
Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus
Aim To investigate the effect of sentinel lymph node (SLN) sampling on the prognosis of patients with middle-high risk endometrial cancer obviously confined to the uterus before surgery.
- Conditions
- Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling, Prognosis
- Trial name
- NCT04276532
- Testing
- sentinel lymph node sampling (SLN), pelvic lymphonodectomy (PLN)
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Xiaojun Chen
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Bortezomib in Treating Patients With Advanced or Metastatic Transitional Cell Cancer of the Bladder, Renal Pelvis, or Ureter
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. PURPOSE: This phase II trial is studying how well bortezomib works in treating patients with advanced or metastatic…
- Trial name
- NCT00066352
- Testing
- bortezomib
- Where
- 15 sites in United States, Canada
- Sponsor
- University Health Network, Toronto
Anxiety
Surveillance Pelvic Examination Anxiety: Brief Coping Skills Intervention
The purpose of this study is to test the feasibility and acceptability of a brief coping skills training program addressing anxiety and pain related to surveillance pelvic examinations for female gynecologic cancer survivors.
- Trial name
- PEACE (NCT05285306)
- Testing
- PEACE Program
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Duke University
Gynecologic Cancer
Prevention of Pelvic Lymphocele by Floseal During Pelvic Lymphadenectomy for Gynecologic Cancer
Pelvic lymph node dissection (PLND) is an important step in the surgical staging and treatment of gynecologic malignancies. Sometimes, complicated lymphoceles after PLND often delay adjuvant treatment including chemotherapy and…
- Trial name
- NCT01974193
- Testing
- Floseal
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Prostate Cancer, Incontinence
Is the HIFEM Procedure an Effective Treatment for Men With Post-prostatectomy Incontinence?
Urinary incontinence after radical prostatectomy surgery is a common condition that negatively affects daily life. Patients often experience discomfort due to urine leakage and the resulting need to use pads daily.
- Conditions
- Prostate Cancer, Incontinence, Pelvic Floor Muscle Weakness
- Trial name
- HIFEM for PPI (NCT06372704)
- Testing
- HIFEM
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Advanced Prostate Cancer
SRAM study_Postate Cancer
This is a phase 2 randomized study for High risk localized prostate cancer (T3 to T4 disease and/or PSA > 20 and/or Gleason score ≥ 8) without evidence of distant and nodal metastasis.
- Trial name
- NCT03938649
- Testing
- Conventional IMRT, SBRT
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- CCTU
Adenocarcinoma of the Bladder, Distal Urethral Cancer
VEGF Trap in Treating Patients With Recurrent, Locally Advanced, or Metastatic Cancer of the Urothelium
This phase II trial is studying the side effects and how well VEGF Trap works in treating patients with recurrent, locally advanced, or metastatic cancer of the urothelium.
- Conditions
- Adenocarcinoma of the Bladder, Distal Urethral Cancer, Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter, Proximal Urethral Cancer
- Trial name
- NCT00407485
- Testing
- ziv-aflibercept, pharmacological study
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Endometrial Adenocarcinoma, Stage III A, B, C
A Phase II Evaluation of Docetaxel and Carboplatin Followed by Tumor Volume Directed Pelvic Irradiation
The purpose of this study is to determine the effectiveness of the combination of the two drugs, docetaxel (Taxotere®) and carboplatin (Paraplatin®) followed by radiation directed at the tumor in treating your endometrial cancer.
- Trial name
- NCT00285415
- Testing
- Docetaxel and Carboplatin
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Carilion Clinic
Bladder Carcinoma, Bladder Urothelial Carcinoma
Testing Anti-Cancer Drugs Erdafitinib With or Without Atezolizumab in Patients With Localized Bladder Cancer Not Able to Receive Cisplatin Chemotherapy, NERA Trial
This phase II trial compares the effect of erdafitinib alone to using the combination of erdafitinib and atezolizumab in treating patients with bladder cancer whose tumor invades the muscular bladder wall (muscle invasive)and who…
- Conditions
- Bladder Carcinoma, Bladder Urothelial Carcinoma, Muscle Invasive Bladder Carcinoma, Renal Pelvis and Ureter Urothelial Carcinoma
- Trial name
- NCT05564416
- Testing
- Atezolizumab, Biospecimen Collection, Computed Tomography
- Sponsor
- National Cancer Institute (NCI)
Prostate Neoplasm
COHORT Trial in Clinical Pelivc Lymph Node Metastatic Prostate Cancer
In local advanced prostate cancer patients with clinically positive metastatic regional lymph node, the optimal treatment is still unanswered.
- Trial name
- NCT03241537
- Testing
- Intensity modulated radiotherapy
- Where
- South Korea
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center