Clinical trials: Pelvic Prolapse
Pelvic Organ Prolapse, Inflammatory Response
Vaginal Probiotics and Pessaries and Their Impact on the Vaginal Microenvironment
In this study, the investigators are evaluating the effect of vaginal probiotics on the bothersome side effects of pessary use and the impact on the vaginal microenvironment (lactobacilli, anaerobic bacteria, mobiluncus bacteria…
- Conditions
- Pelvic Organ Prolapse, Inflammatory Response, Dysbiosis
- Trial name
- NCT04118049
- Testing
- BiopHreshTM vaginal probiotic supplement (Good Clean Love, Inc. Eugene, OR) and RestoreTM gel., Standard Care
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Hartford Hospital
Pelvic Organ Prolapse
Perineorrhaphy Outcomes Related to Body Imagery
The purpose of this study is to determine whether performing a perineorrhaphy during a reconstructive surgery indicated for pelvic organ prolapse (POP) affects a patient's body image.
- Trial name
- POETRY (NCT02548858)
- Testing
- Perineorrhaphy, No Perineorrhaphy
- Where
- 2 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Uterine Fibroids (UF), Menstrual Disorders
Hugo™ Robotic-Assisted Surgery (RAS) System in Gynecological Subjects (Embrace Gynecology)
The purpose of this research is to evaluate the safety and performance of the investigational Medtronic Hugo™ Robotic Assisted Surgery (RAS) system when used during hysterectomy procedures, including patients being treated for…
- Conditions
- Uterine Fibroids (UF), Menstrual Disorders, Adenomyosis of Uterus, Endometriosis
- Trial name
- Embrace Gyn (NCT07120945)
- Testing
- Robotic Assisted-Surgery (RAS) Hysterectomy
- Where
- 5 sites in United States
- Volunteers
- 70 people
- Sponsor
- Medtronic - MITG
Incontinence, Pelvic Organ Prolapse
The Effect of the Mode of Delivery to the Pelvic Floor Function
The childbirth is one of the risk factors for pelvic organ prolapse. In order to prevent the pelvic organ prolapse, the physicians do not routinely advice any exercises after deliveries.
- Trial name
- NCT04474275
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Giresun University
Pelvic Organ Prolapse
Prospective Assessment of Robotic Sacrocolpopexy: a European Multicentric Cohort (PARSEC)
The purpose of this study is to prospectively assess the outcomes of robotic sacrocolpopexy for repair of pelvic organ prolapse in high volume european centers.
- Trial name
- PARSEC (NCT01598467)
- Testing
- Robotic assisted sacrocolpopexy (RASC)
- Where
- Ireland
- Volunteers
- 300 people
- Sponsor
- Femke van Zanten
Pelvic Organ Prolapse, Cystocele
Laparoscopic Three-dimensional Versus Two-dimensional Sacral Colpopexy and Paravaginal Repair
Compare operative times and complications of sacral colpopexy and paravaginal repair between two-dimensional and three-dimensional laparoscopic systems.
- Trial name
- NCT02258230
- Testing
- 3D mode of the 3D Laparoscopic Video System, 2D mode of the 3D Laparoscopic Video System
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- Olympus Corporation of the Americas
Pelvic Organ Prolapse
Centered Surgery - Preoperative Counseling and Patient Satisfaction
This study is a prospective cohort study which aims to assess patient satisfaction and preparedness for surgery through two methods of preoperative counseling: standard individual phone calls versus virtual group sessions called…
- Trial name
- NCT07471464
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- The Cleveland Clinic
Pelvic Organ Prolapse
Laparoscopic Hysterectomy With Vaginal Vault Suspension to the Uterosacral Ligaments for Stage II-III Pelvic Organ Prolapse.
The International Continence Society defines post-hysterectomy vault prolapse (PHVP) as descent of the vaginal cuff scar below a point that is 2 cm less than the total vaginal length above the plane of the hymen.
- Trial name
- LULS-1 (NCT03553511)
- Testing
- Vaginal vault suspension to the uterosacral ligaments, McCall culdoplasty
- Volunteers
- 60 people
- Sponsor
- Università degli Studi dell'Insubria
Uterine Prolapse, Urinary Incontinence
The Immune Reactivity of Biofilms in Vaginal Mesh Erosion.
Aging, birth trauma and extensive pelvic surgery are the causes known to cause advanced pelvic organ prolaspe, fecal as well as urinary incontinence.
- Conditions
- Uterine Prolapse, Urinary Incontinence, Fecal Incontinence
- Trial name
- NCT00564044
- Testing
- excision of the protruding mesh and its surrounding vaginal tissue
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- Chang Gung Memorial Hospital
Surgical Repair of Middle Compartment Prolapse (Vaginal Vault or Uterine Prolapse) With or Without Cystocele
Safety and Efficacy of a Transvaginal Suture Capturing Mesh Device
To perform a clinical safety and efficacy assessment of the Uphold LITE system for pelvic organ prolapse in a prospective multicenter, single cohort study.
- Trial name
- NCT01823055
- Testing
- Transvaginal suture capturing mesh device
- Volunteers
- 214 people
- Sponsor
- Karolinska Institutet
Pelvic Organ Prolapse (POP)
Vaginal Estrogen for Improvement of Outcomes Following Pelvic Organ Prolapse Surgery
This open-label randomized control trial will study the use of vaginal estrogen in the first six weeks after pelvic organ prolapse (POP) repair surgery.
- Trial name
- VEPO (NCT07030426)
- Testing
- Vaginal Estrogen - Twice Weekly, Vaginal Estrogen - Daily
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- Sarah Wozney
Genital Diseases, Female, Hysterotomy; Affecting Fetus
Effect of Salpingectomy During Conservative Hysterectomy
The study compares the effect of bilateral salpingectomy associated with conservative hysterectomy on ovarian function to the standard hysterectomy with conservation of both ovaries and tubes in terms of hormone assays, ovarian…
- Conditions
- Genital Diseases, Female, Hysterotomy; Affecting Fetus, Leiomyomata Uteri, Adenomyosis, Endometriosis
- Trial name
- SALPINGOVA (NCT01628432)
- Testing
- conservative hysterectomy I, Conservative hysterectomy II
- Where
- 7 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Tours
Pelvic Organ Prolapse
Anterior Vaginal Wall Repair With Mesh in Combination With TVT-O to Reduce Urinary Stress Incontinence
Urinary stress incontinence is defined as leakage of urine during stress. Urinary stress incontinence is a health problem with social, economic and psychological consequences.
- Trial name
- NCT01507714
- Testing
- Preventive transobturator tension free vaginal tape
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- HaEmek Medical Center, Israel
Pelvic Organ Prolapse
Vaginal Prolapse Pessary Material Trial PVC vs Silicon
The goal of this clinical trial is to determine the effect of vaginal ring pessary material on pessary complications and patients' satisfaction. Participants who are using PVC (polyvinyl chloride) pessary will be randomized to 1.
- Trial name
- NCT06641804
- Testing
- Pessary care, change of pessary
- Volunteers
- 140 people
- Sponsor
- Princess Margaret Hospital, Hong Kong
Pelvic Organ Prolapse
Polypropylene Mesh in Prolapse Surgery
The purpose of this study was to report the long-term objective and subjective outcome after prolapse surgery with polypropylene mesh.
- Trial name
- NCT02383199
- Volunteers
- 161 people
- Sponsor
- Turku University Hospital
Pelvic Organ Prolapse
IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair
The purpose of this study is to determine whether preoperative IV Acetaminophen reduces postoperative pain and narcotic consumption in women undergoing surgical repair of pelvic organ prolapse.
- Trial name
- NCT02155738
- Testing
- IV Acetaminophen, IV normal saline
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Halina M Zyczynski, MD
Rectal Prolapse
FOAM: Functional Outcome After Ventral Mesh Rectopexy
Rectal prolapse is a protrusion of rectal wall through the anus. A surgical technique called Ventral mesh rectopexy has become a standard procedure for this condition in many centers.
- Trial name
- NCT06455501
- Testing
- Ventral mesh rectopexy
- Volunteers
- 70 people
- Sponsor
- Uppsala University
Rectocele
Graft-Augmented Rectocele Repair-A Randomized Surgical Trial
The purpose of this study is to determine whether adding a graft during a rectocele repair will improve the success rate of the repair.
- Trial name
- NCT00321867
- Testing
- Graft augmented posterior repair, Control
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Urinary Incontinence, Pelvic Organ Prolapse
Health Care Seeking Behavior and Knowledge Assessment of Hungarian Women About Pelvic Floor Disorders
The aim of this study is to assess women's health care seeking behavior and knowledge of urinary incontinence and pelvic organ prolapse and to culturally adapt the Prolapse and Incontinence Knowledge Questionnaire (PIKQ) for the…
- Conditions
- Urinary Incontinence, Pelvic Organ Prolapse, Knowledge, Attitudes, Practice, Behavior, Health
- Trial name
- NCT05567900
- Where
- Hungary
- Volunteers
- 596 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Pelvic Organ Prolapse
Does Intravenous Tranexamic Acid Reduce Blood Loss During Vaginectomy?
There are many risks for patients undergoing surgery, with blood loss and the risk of resulting anemia and blood transfusion being a common one.
- Trial name
- NCT03216083
- Testing
- Tranexamic Acid Injectable Solution
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Mount Sinai Hospital, Canada