Clinical trials: Pelvic Prolapse
Pelvic Organ Prolapse
Xenform Postmarket Surveillance Study
To compare transvaginal repair with a biologic graft to traditional native tissue repair in women surgically treated for anterior and/or apical pelvic organ prolapse.
- Trial name
- Xenform (NCT01945580)
- Testing
- Prolapse Repair
- Where
- 25 sites in United States
- Volunteers
- 374 people
- Sponsor
- Boston Scientific Corporation
Pelvic Organ Prolapse
Comparison of Laparoscopic Pectopexy and Laparoscopic Lateral Suspension Techniques in Uterine-preserving Apical Prolapsus Repair
The aim of the study will be to compare the laparoscopic pectopexy (LP) and laparoscopic lateral suspension (LLS) techniques in the management of uterine sparing apical prolapse (POP-Q >2) at 1 year and yearly up to 2 years.
- Trial name
- NCT05143658
- Testing
- LLS versus LP
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pelvic Organ Prolapse
Exair® Versus Native Tissue Repair for Prolapse
The purpose of this study is to compare safety and effectiveness of the Exair Prolapse Repair System for treatment of pelvic organ prolapse to traditional native tissue repair through 36 months of follow-up.
- Trial name
- NCT02162628
- Testing
- Exair Prolapse Repair System, Total Native Tissue Repair
- Where
- 14 sites in United States, Canada
- Volunteers
- 79 people
- Sponsor
- Coloplast A/S
Pelvic Organ Prolapse
Attitude and Success Rate of Women With Pelvic Organ Prolapse on Self-management of Vaginal Pessary
This is a prospective cohort study aims at assessing patient's attitude towards self-management of vaginal pessary, and identifying factors that affect patient's level of acceptance towards self-management.
- Trial name
- NCT06246721
- Testing
- Self-management of vaginal pessary
- Where
- Hong Kong
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Pelvic Organ Prolapse, Uterine Prolapse
Transvaginal Sacrospinous Hysteropexy Versus Laparoscopic Uterine Lateral Suspension
Transvaginal or transabdominal surgeries are current choices of uterus-preserving surgeries for pelvic organ prolapse. Laparoscopic lateral uterine suspension, a modified surgical approach of uterine suspension from bilateral…
- Trial name
- NCT05586984
- Testing
- Laparoscopic uterine lateral suspension, Transvaginal sacrospinous fixation
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Cheng-Kung University Hospital
Pelvic Organ Prolapse
the Anatomical Reduction and Functional Recovery Effects of Two Transvaginal Apical Slings on Pelvic Organ Prolapse
The study is a prospective study at a single institution. Investigators create strict inclusion and exclusion criteria, selecting 124 patients with POP(≥II degree and have symptoms that need operation) .
- Trial name
- NCT05189665
- Testing
- Extraperitoneal high sacral ligament suspension surgery, Sacrospinous ligament fixation
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Peking University People's Hospital
Pelvic Organ Prolapse
Comparison of Vaginal and Laparoscopic Apical Fixation Techniques for Pelvic Organ Prolapse Treatment
This is a prospective randomized controlled study, designed to compare efficacy and safety of two methods of apical fixation in patients with pelvic organ prolapse (POP) - sacrospinous hysteropexy (SSHP) with synthetic mesh and…
- Trial name
- NCT05420831
- Testing
- Vaginal, Laparoscopic
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Saint Petersburg State University, Russia
Pelvic Organ Prolapse
POPQ Versus Simulated Apical Support as a Guideline for Anterior or Posterior Repair During Vaginal Reconstruction
The objective of the Preoperative Pelvic Organ Prolapse Quantification (POPQ) versus Simulated Apical Support as a Guideline for Anterior or Posterior Repair at the Time of Transvaginal Apical Suspension (PREPARE) trial is to…
- Trial name
- NCT03187054
- Testing
- anterior or posterior colporrhaphy
- Where
- South Korea
- Volunteers
- 335 people
- Sponsor
- Seoul National University Hospital
Pelvic Organ Prolapse
Do Patients With Early Post Operative Recurrence of Pelvic Organ Prolapse Have a Genetic Predisposition?
The objective is to explore the genetic predisposition to early pelvic organ prolapse after adequate surgical repair by exploring the association between pelvic organ prolapse recurrences and certain polymorphisms.
- Trial name
- NCT01614587
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Atlantic Health System
Pelvic Organ Prolapse, Surgical Procedure; Complications, Late Effect of Complications
LOOP VS DOUBLE SUTURE TECHNIQUES IN SACROSPINOUS FIXATION: A TWO-YEAR STUDY
This retrospective cohort study aimed to compare clinical outcomes between the classical double suture technique and a modified loop suture technique used in sacrospinous ligament fixation for stage 3 or 4 pelvic organ prolapse.
- Trial name
- NCT07106866
- Testing
- sacrospinous ligament fixation
- Where
- Turkey (Türkiye)
- Volunteers
- 195 people
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Rectocele; Female, Pelvic Organ Prolapse
Gamma-irradiated Amniotic Membrane Graft in Posterior Colporrhaphy
The goal of this clinical trial is to test the benefit of using gamma-irradiated amniotic membrane as a graft in surgical repair for women with posterior vaginal wall defects.
- Trial name
- NCT06117670
- Testing
- posterior colporrhaphy using gamma-irradiated amniotic membrane as a graft
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Ain Shams Maternity Hospital
Pelvic Organ Prolapse
The Development of De-novo Stress Urinary Incontinence After Stage II-III Pelvic Organ Prolapse Surgery
Surgery for Stage II-III Pelvic organ prolapse
- Trial name
- NCT03221725
- Testing
- sacrospinous ligament fixation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pelvic Organ Prolapse, Stress Urinary Incontinence
Outcomes of Pelvic Surgery With and Without Anti-incontinence Procedure in Occult Stress Urinary Incontinence Patients
1. To evaluate whether a standardized tension-free vaginal tape-obturator(TVT-O) procedure, when added to a planned improved reconstruction pelvic surgery, improves the rate of urinary stress continence in subjects with occult…
- Conditions
- Pelvic Organ Prolapse, Stress Urinary Incontinence, Other Specified Urinary Incontinence
- Trial name
- PTOS (NCT02193607)
- Testing
- TVT-O, Improved reconstruction pelvic surgery
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Peking Union Medical College Hospital
Pelvic Organ Prolapse
Effects of Pelvic Floor Muscle Training With & Without Hypopressive Exercises
Pelvic Organ Prolapse (POP) is a prevalent condition affecting women's quality of life due to the descent of pelvic organs caused by weak pelvic floor muscles (PFMs).
- Trial name
- NCT07440875
- Testing
- hypopressive excercises, pelvic training excercises
- Where
- Pakistan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pelvic Organ Prolapse
Restricted Convalescence: Outcomes Following Urogynecologic Procedures
The investigators are conducting a study to better understand the relationship between activity restrictions and women's satisfaction following urogynecologic surgery for prolapse.
- Trial name
- ReCOUP (NCT02138487)
- Testing
- liberal postoperative activity, Restricted postoperative activity
- Where
- 3 sites in United States
- Volunteers
- 105 people
- Sponsor
- Northwestern University
Pelvic Organ Prolapse
Complications Associated With Promontofixation for Pelvic Organ Prolapse: Comparing Robot Assisted Laparoscopic and Non-robot Assisted Laparoscopic Surgical Procedures
The primary objective of this study is to compare 30-day complication rates associated with promontofixation for pelvic organ prolapse performed via a robot-assisted laparoscopic technique versus a non-robot-assisted laparoscopic…
- Trial name
- RoboLaps (NCT01320215)
- Testing
- Robot-assisted promontofixation, Non-robot assisted promontofixation
- Where
- 18 sites in France
- Volunteers
- 365 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery
Urinary Continence After Vaginal Surgery for Genital Prolapse in the Spanish Population.
Surgical correction of pelvic organ prolapse (POP) may be associated with the development of postoperative stress urinary incontinence (SUI).
- Conditions
- Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Urinary Incontinence (UI)
- Trial name
- NCT07628036
- Testing
- Vaginal surgery for pelvic organ prolapse
- Where
- 4 sites in Spain
- Volunteers
- 1,042 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pelvic Organ Prolapse, Pelvic Organ Prolapse Vaginal Surgery
To Explore the Surgical Outcomes and Safety of an Innovative Laparoscopic Uterine Pectopexy Technique Using Inverted T-meshes for Simultaneous Apical and Anterior Vaginal Repair.
Patients referred for pelvic reconstructive surgery frequently present with combined anterior and apical vaginal wall prolapse. Previous studies found that anterior compartment involvement is the most common and serious defect…
- Conditions
- Pelvic Organ Prolapse, Pelvic Organ Prolapse Vaginal Surgery, Pectopexy, Sacrocolpopexy
- Trial name
- NCT07411898
- Testing
- Laparoscopic pectopexy, Laparoscopic sacrocolpopexy
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- Chung Shan Medical University
Pelvic Organ Prolapse, Sexual Function Abnormal
Four-arm Mesh for Vaginal Stump Prolapse
To estimate the safety and efficacy of performing modified anterior transvaginal mesh surgery using polypropylene mesh for treatment of advanced urogenital prolapse after hysterectomy (stage III and IV vc Pelvic Organ Prolapse…
- Trial name
- NCT03809806
- Testing
- 4-arm polypropylene mesh surgery, The Female Sexual Function Index (FSFI) questionnaire, King Health Questionnaire (KHQ)
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Lublin
Pelvic Organ Prolapse
Study of Outpatient Management for Promontofixation by Laparoscopy
Laparoscopic promontofixation is becoming increasingly common and is currently the standard surgical procedure for pelvic prolapse, with few complications including exposure and mesh infection.
- Trial name
- NCT03573752
- Testing
- outpatient management for promontofixation by laparoscopy, questionnaire
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France