Clinical trials: Pemphigus Disease
Pemphigus Vulgaris
Use of KC706 for the Treatment of Pemphigus Vulgaris
The purpose of this study is to determine whether KC706 is effective in the prevention and healing of blisters in patients with pemphigus vulgaris, while the patient remains on stable doses of corticosteroids and/or…
- Trial name
- NCT00606749
- Testing
- KC706
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kemia, Inc
Hailey-Hailey Disease
Skin Microbiome Profile in Hailey-Hailey Disease
"Hailey-Hailey disease is an autosomal dominant disorder caused by a genetic defect in a calcium ATPase (ATP2C1) leading to a defect in keratinocyte adhesion.
- Trial name
- NCT05007223
- Testing
- Doxycycline
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Pemphigus Vulgaris
Comparing DCP and DAP for Pemphigus Vulgaris
What's the study about? This study focused on comparing two different treatments for pemphigus vulgaris, a skin condition caused when body's immune system works against itself.
- Trial name
- DCP;DAP (NCT06846255)
- Testing
- Dexamethasone Cyclophosphamide Pulse therapy, Dexamethasone Azathioprine Pulse therapy
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Pemphigus Vulgaris (PV)
Trichoscopy as a Monitoring Tool for Activity and Remission in Pemphigus Vulgaris: A Clinical Study Supported by Immunological Evaluation.
Pemphigus vulgaris (PV) is a potential life-threatening autoimmune bullous disorder presenting with multiple erosions and flaccid blisters that can involve both mucous membrane and skin.
- Trial name
- NCT06863454
- Testing
- Trichoscopy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pemphigus Vulgaris, Skin Erosion
Effect of Topical Insulin on Healing Rate of Pemphigus Lesions
This study investigates the efficacy of topical insulin in promoting healing of pemphigus vulgaris erosions. Twenty patients with pemphigus vulgaris were enrolled, each contributing three comparable lesions randomly allocated to…
- Conditions
- Pemphigus Vulgaris, Skin Erosion, Autoimmune Blistering Disease
- Trial name
- NCT07461103
- Testing
- insulin glargine, human insulin, 0.9% Normal Saline
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Pemphigus Vulgaris
Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris
The purpose of this 12-month study was to determine the efficacy of dapsone as a glucocorticoid-sparing agent in maintenance phase pemphigus vulgaris.
- Trial name
- NCT00429533
- Testing
- Dapsone
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- Jacobus Pharmaceutical
Pustular Psoriasis (PP), Generalized Pustular Psoriasis (GPP)
Evaluating Legit.Health Plus Support for Improving Diagnosis of Generalized Pustular Psoriasis and Other Skin Conditions Among Primary Care Physicians and Dermatologists
This study aims to determine if an artificial intelligence (AI) medical device can help healthcare professionals more accurately diagnose rare and complex skin conditions.
- Conditions
- Pustular Psoriasis (PP), Generalized Pustular Psoriasis (GPP), Eczema Atopic Dermatitis, Acute Generalized Exanthematous Pustulosis
- Trial name
- LegitHealth BI (NCT07428915)
- Testing
- AI-based medical device for aided diagnosis in Dermatology
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- AI Labs Group S.L
Inherited Epidermolysis Bullosa, Ichthyosis
FARD (RaDiCo Cohort) (RaDiCo-FARD)
The goal of this observational study is to conduct a prospective assessment of the individual Burden of 9 rare skin diseases to assess disability in the broadest sense of the term (psychological, social, economic and physical)…
- Conditions
- Inherited Epidermolysis Bullosa, Ichthyosis, Ectodermal Dysplasia, Incontinentia Pigmenti
- Trial name
- FARD (NCT05954416)
- Where
- 15 sites in France
- Volunteers
- 900 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pemphigus Vulgaris
Role of Tzanck Smear in Determining Pemphigus Vulgaris Disease Activity
Aim: Pemphigus vulgaris (PV) is a rare, life-threatening autoimmune bullous disease that can involve the skin and mucous membranes, characterized by intraepidermal bullae and eroded lesions caused by rupture of the bullae.
- Trial name
- NCT05338112
- Testing
- Tzanck smear
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medeniyet University
Pemphigus
A Study of PRN1008 in Patients With Pemphigus
This was a Phase 3 randomized, parallel-group, double-blind, placebo-controlled trial (blinded treatment [BT] period) followed by an open-label extension [OLE] period intended to evaluate the efficacy and safety of oral PRN1008…
- Trial name
- NCT03762265
- Testing
- Rilzabrutinib
- Where
- 88 sites in United States, Argentina and 17 more
- Volunteers
- 131 people
- Sponsor
- Principia Biopharma, a Sanofi Company
Autoimmune Diseases
Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the "RITUXIMAB 3" Trial
Pemphigus is an autoimmune disease specific to the skin and mucous membranes characterized by the production of IgG4 isotype autoantibodies (AC) directed mainly against two proteins involved in interkeratinocyte adhesion…
- Trial name
- LTFURITUX3 (NCT03790293)
- Testing
- Rituximab, corticosteroids'therapy
- Where
- 25 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Pemphigus
Use of Infliximab for the Treatment of Pemphigus Vulgaris
Pemphigus vulgaris (PV) is a rare skin disorder that causes blistering of the skin and mucous membranes. Infliximab is a man-made antibody used to treat certain types of immune system disorders, including rheumatoid arthritis and…
- Trial name
- NCT00283712
- Testing
- Infliximab
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pemphigus Vulgaris, Pemphigus Foliaceus
A Study to Assess the Efficacy and Safety of a Subcutaneous Formulation of Efgartigimod PH20 SC in Adults With Pemphigus (Vulgaris or Foliaceus)
This is a prospective, multicenter, randomized, double-blinded, placebo-controlled trial to investigate the efficacy, safety, patient outcome measures, tolerability, immunogenicity, PK, and PD of efgartigimod PH20 SC in adult…
- Trial name
- ADDRESS (NCT04598451)
- Testing
- efgartigimod PH20 SC, prednisone
- Where
- 134 sites in United States, Australia and 19 more
- Volunteers
- 222 people
- Sponsor
- argenx
Pemphigus
Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus
The purpose of this research is to study alternative treatments for the skin disease pemphigus (a rare autoimmune blistering disorder of the skin) by using sirolimus, an immunosuppressive drug.
- Trial name
- NCT01313923
- Testing
- Sirolimus (formerly known as Rapamycin)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, Irvine
Oral Lesions in Patients With Pemphigus Vulgaris
Comparison of the Efficacy of Clobetasol Propionate 0.05% Mouthwash, Photobiomodulation, and Their Combination in Managing of Oral Lesions in Patient With Pemphigus Vulgaris.
Pemphigus vulgaris (PV) is a chronic, potentially life-threatening autoimmune mucocutaneous disorder that significantly impairs patients' quality of life.
- Trial name
- NCT07641725
- Testing
- Clobetasol propionate 0.05% Mouthwash, diode laser for photobiomodulation, clobetasol propionate 0.05% mouthwash + photobiomodulation
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Hailey Hailey Disease
M. Hailey-Hailey: hSPCA1 Expression and Skin Structure Upon Laser Therapy
Hailey-Hailey disease is a genetic acantholytic dermatosis characterized by continuous erosion of the skin that results in a burning, painful sensation and restricts the patient in daily life.
- Trial name
- NCT03849989
- Testing
- Skin biopsy
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Maastricht University Medical Center
Pemphigus, Pemphigus Vulgaris (PV)
Efficacy and Safety Evaluation of Anti-CD20 Monoclonal Antibody Combined with Azathioprine and Corticosteroids in the Treatment of Pemphigus Vulgaris
A prospective cohort study was conducted, following patients for 36 weeks from January 1, 2023, to April 30, 2024. Patients meeting the diagnostic criteria were nonrandomly grouped based on screening results.
- Trial name
- NCT06654817
- Testing
- Ofatumumab subcutaneous injection
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Chao Ji
Pemphigus Vulgaris
A Study of the Safety and Tolerability of INCB050465 in Pemphigus Vulgaris
The purpose of this study is to assess the safety and tolerability of parsaclisib in participants with mild to moderate pemphigus vulgaris.
- Trial name
- NCT03780166
- Testing
- Parsaclisib
- Sponsor
- Incyte Corporation
Pemphigus
Phase II Study of High-Dose Cyclophosphamide in Patients With Refractory Pemphigus
OBJECTIVES: I. Determine the response rate and 1-year event-free survival of patients with refractory pemphigus treated with high-dose cyclophosphamide.
- Trial name
- NCT00010413
- Testing
- cyclophosphamide, filgrastim
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Pemphigus
Coagulation Activation in Patients With Pemphigus
Aim of work: 1. To evaluate the plasma markers of coagulation activation: prothrombin F1+2 and d-dimer levels in pemphigus patients with active disease and compare them with age and sex-matched controls. 2.
- Trial name
- NCT06285435
- Testing
- prothrombin fragment 1+2
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University