Clinical trials: Penicillin Allergy
Penicillin Allergy
Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams
This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.
- Trial name
- NCT00789217
- Testing
- Immediate skin test
- Where
- Thailand
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Beta Lactam Adverse Reaction
B-lactam Databank Algorithm
Background: Antibiotic allergy constitutes a major health problem with serious medical and financial consequences when under- but also overdiagnosed. About one and a half million Belgians report having an allergy to penicillin.
- Trial name
- NCT06243380
- Where
- Belgium
- Volunteers
- 921 people
- Sponsor
- University Hospital, Antwerp
Drug Allergy, Penicillin Allergy
Provocation After Nurse-Directed Assessment (PANDA) Study
The study aims to evaluate the effectiveness and safety of a collaborative nurse-allergist approach in penicillin allergy delabeling services.
- Trial name
- PANDAS (NCT07127835)
- Testing
- Nurse-led penicillin allergy delabelling service, Allergist-led penicillin allergy delabelling service
- Where
- 4 sites in Hong Kong
- Volunteers
- 440 people
- Sponsor
- The University of Hong Kong
Beta Lactam Allergy in Patients With a Hematologic Malignancy
Allergy Delabeling in Antibiotic Stewardship - Evaluations
The goal of this RENEW-EVAL project is to understand the potential barriers to implementation of the RENEW intervention into the routine clinical care of patients with a hematological malignancy.
- Trial name
- RENEW-EVAL (NCT06967467)
- Testing
- Semi-structured interview, Survey, Ethnographic observation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Staphylococcus Aureus Infection
Plasma Pharmacological Monitoring of M Penicillins in Methicillin-sensitive Staphylococcus Aureus Bacteremia
The treatment of Methicillin-sensitive Staphylococcus aureus bacteremia is based on the first-line use of cefazolin or M penicillins (oxacillin and cloxacillin).
- Trial name
- DOSESACLOXA (NCT06495697)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Penicillin Allergy
Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge
The goal of this clinical trial is to learn about dosing when testing to see if a penicillin allergy label can be removed from adults that had been labeled as "penicillin-allergic" previously.
- Trial name
- NCT06303128
- Testing
- Amoxicillin 250 MG, Amoxicillin 62.5mg, Amoxicillin 187.5mg
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- James Tarbox, MD
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allergy
Negative Predictive Value and NIC of Beta-Lactam Antibiotics.
The researchers are trying to evaluate how much medication is required for allergy skin testing and to determine the likelihood that patients with a negative test truly don't have an allergy to the tested drug of skin testing to…
- Trial name
- NCT04126096
- Testing
- Skin Testing beta-lactams
- Where
- 2 sites in United States
- Volunteers
- 747 people
- Sponsor
- Mayo Clinic
Allergy Penicillin
Evaluation of a Direct Oral Penicillin Challenge in a Rural Community
This study aims to evaluate the outcomes of a rural-DOC Pilot clinic which will be established in the Huntsville site of Muskoka Algonquin Healthcare.
- Trial name
- DOC (NCT06192277)
- Testing
- Screening, Low dose Penicillin, Standard dose Penicillin
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northern Ontario School of Medicine
Penicillin Allergy
The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal
Currently it is estimated that at least 25 million people in the United States are labeled as penicillin allergic although less than 1.5 million of these are truly allergic.
- Trial name
- NCT03702270
- Testing
- Penicillin Allergic Risk Stratification Best Practice Alert
- Where
- United States
- Volunteers
- 2,052 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Drug Hypersensitivity
Allergy Testing of Patients Labeled as Penicillin Allergic
Patients labeled as penicillin allergic, rarely have this confirmed and being labeled as "penicillin allergic" is associated with increased health care costs, adverse effects and antibiotic resistance.
- Trial name
- NCT02983630
- Testing
- Penicillin allergy testing
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Penicillin Allergy
Amoxicillin Challenge for Penicillin Allergy Diagnosis
False diagnosis of penicillin allergy are frequently reported, and have been proven detrimental to patients. Current guidelines for the assessment of drug allergies recommend that penicillin allergy be evaluated first with prick…
- Trial name
- Pen-VIE (NCT03757052)
- Testing
- Penicillin Skin Testing
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Penicillin Allergy, Hypersensitivity, Immediate
Risk-stratified Testing for Safe Removal of Penicillin Allergy Labels
The aim of this clinical trial is to analyze the negative predictive capacity and safety of risk-stratified direct drug provocation tests for patients with self-reported penicillin allergies.
- Conditions
- Penicillin Allergy, Hypersensitivity, Immediate, Hypersensitivity, Delayed, Hypersensitivity Response
- Trial name
- NCT06755281
- Testing
- Direct Oral challenge, standard of care
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Deniz Göcebe
Infection
Allergy Antibiotics And Microbial Resistance
ALBAMA study is designed to find out if the effects of Penicillin allergy assessment pathway (PAAP) intervention is on penicillin prescribing
- Trial name
- ALABAMA (NCT04108637)
- Testing
- penicillin allergy assessment pathway
- Where
- United Kingdom
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Penicillin Allergy, Penicillin Reaction
Penicillin De-labeling in the Pediatric Primary Care Setting
While reported adverse reactions to penicillins are common, most patients with a penicillin allergy label can safely tolerate penicillins, and elective evaluation for penicillin allergy has been recommended.
- Trial name
- NCT05010304
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Texas Southwestern Medical Center
Penicillin, Drug Allergy
Inpatient Penicillin Delabeling for Low-Risk Patients
This study seeks to enroll patients admitted to a children's hospital with identified penicillin allergy. A screening checklist is performed to identify patients with very low or low risk histories of penicillin allergy to offer…
- Trial name
- NCT06414694
- Testing
- Direct Oral Challenge
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Tennessee
Drug Hypersensitivity
Drug Allergy Labels After Drug Allergy Investigation
The aim of this study is to investigate the degree of match between the drug allergy label in the hospital's electronic health record and primary care's electronic health record among patients who previously have been drug…
- Trial name
- NCT04827602
- Testing
- Drug allergy label status in electronic health records
- Where
- Denmark
- Volunteers
- 849 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy
Increasing drug resistance presents a significant challenge to the efficacies of common empiric eradication regimens for Helicobacter pylori treatment in the mainland of China.
- Trial name
- NCT03708848
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Clarithromycin
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine