Clinical trials: Penicillin Reaction
History of IgE Dependent Reaction to a Penicillin Product
Evaluation of Skin Testing Reagents for Penicillin Allergy
A self- or parent-reported history of penicillin allergy excludes approximately 10% of the US population from receiving penicillin (Kerr 1994, Kagy, Blaiss 1998, Solensky et al. 2000, Neugut et al. 2001).
- Trial name
- NCT01818336
- Testing
- Penicillin skin test kit
- Where
- 13 sites in United States
- Volunteers
- 481 people, healthy volunteers welcome
- Sponsor
- AllerQuest LLC
Penicillin Allergy
Equivalency of Penicilloate Skin Test Reactivity Prepared by a Modified Alkaline Hydrolysis Technique
The primary objective of the study is to evaluate the equivalency of the skin test reactivity to penicilloate prepared by our new method of penicilloate preparation versus our old method of penicilloate preparation.
- Trial name
- NCT00589251
- Testing
- penicillin skin test
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pharmacokinetics, Beta Lactam Adverse Reaction
Beta-lactam Pharmacokinetics in Secondary Care
Currently in the UK, TDM is routinely performed for aminoglycosides and glycopeptide antimicrobial agents, given fears over the narrow therapeutic window of these agents and the serious adverse events associated with toxicity.
- Conditions
- Pharmacokinetics, Beta Lactam Adverse Reaction, Penicillin Allergy
- Trial name
- NCT03033394
- Testing
- Beta-lactam antibiotic
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- Imperial College London
Penicillin Allergy, Penicillin Sensitivity
Inpatient Penicillin Allergy Delabeling Study
The study will identify pediatric patients 3-18 years old who have penicillin allergy label in the electronic medical record. Those who are identified will be stratified into no-risk, low-risk and high-risk category using a…
- Conditions
- Penicillin Allergy, Penicillin Sensitivity, Penicillin Reaction, Penicillin Intolerance
- Trial name
- NCT05020327
- Testing
- Graded Oral Amoxicillin Challenge, De-labelling in electronic medical record, Referral to Allergy Immunology/Retention of Allergy Label
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Penicillin Allergy, Aminopenicillin Allergy
The Diagnosis of Beta-lactam Hypersensitivity in Thailand
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand.
- Conditions
- Penicillin Allergy, Aminopenicillin Allergy, Beta Lactam Adverse Reaction
- Trial name
- NCT01667055
- Where
- Thailand
- Volunteers
- 500 people
- Sponsor
- Chulalongkorn University
Drug Allergy, Cephalosporin Allergy
Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in…
- Conditions
- Drug Allergy, Cephalosporin Allergy, Drug Hypersensitivity, Antibiotic Allergy
- Trial name
- DACAT (NCT06406114)
- Testing
- Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Beta Lactam Adverse Reaction
B-lactam Databank Algorithm
Background: Antibiotic allergy constitutes a major health problem with serious medical and financial consequences when under- but also overdiagnosed. About one and a half million Belgians report having an allergy to penicillin.
- Trial name
- NCT06243380
- Where
- Belgium
- Volunteers
- 921 people
- Sponsor
- University Hospital, Antwerp
Penicillin Allergy, Penicillin Reaction
Penicillin De-labeling in the Pediatric Primary Care Setting
While reported adverse reactions to penicillins are common, most patients with a penicillin allergy label can safely tolerate penicillins, and elective evaluation for penicillin allergy has been recommended.
- Trial name
- NCT05010304
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Texas Southwestern Medical Center
Syphilis Infection, Benzathine Penicillin Adverse Reaction
LIMIT Trial - Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema Pallidum Treatment
There is evidence to suggest that lidocaine can help reduce the pain associated with intramuscular injections of benzathine penicillin G (BPG) or Bicillin, used to treat syphilis infections.
- Trial name
- LIMIT (NCT06391125)
- Testing
- normal Saline, Lidocaine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Penicillin Allergy
Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin
The purpose of this study is to examine whether oral challenge with penicillin for patients with a known history of non-life threatening allergic reaction to penicillin is well-tolerated irrespective of skin-testing results
- Trial name
- NCT00363688
- Testing
- Penicillin test and challenge
- Where
- Israel
- Sponsor
- Meir Medical Center