Clinical trials: Penile Hypospadias
Pediatric Patients Undergoing Hypospadias Surgery
Does the Single Use of Intravenous Dexamethasone Enhance Analgesic Quality of Pudendal Analgesia in Children Undergoing Hypospadias Surgery?
Hypospadias is a congenital malformation that occurs in an embryological process, and occurs with an incidence of about 1/300 in male children.
- Trial name
- NCT04836962
- Testing
- normal saline, dexamethasone
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yonsei University
Proximal Penile Hypospadias
Graft Versus Flap in Management of Proximal Penile Hypospadias
Proximal hypospadias (penoscrotal, scrotal, and perineal types) account for approximately 20% of all cases . The management of hypospadias has greatly improved over the past two decades since the introduction of tubularized…
- Trial name
- NCT06565286
- Testing
- inner preputial graft versus transverse preputial island flap in two-stage repair of proximal penile hypospadias
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Hypospadias
Evaluation of Double Faced Transverse Preputial Onlay Island Flap for Hypospadias Repair in Pediatrics
Evaluation of double faced transverse preputial onlay island flap for hypospadias repair in pediatrics. The preputial onlay island flap technique has been popularized for hypospadias repair as a result of offering a consistent…
- Trial name
- DFOF#TIOF (NCT05144659)
- Testing
- Double faced transverse preputial onlay island flap, Transverse inner preputial onlay island flap
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Proximal Hypospadias, Modified Duckett Urethroplasty
Hybrid Duckett vs Modified Duckett Urethroplasty for Proximal Hypospadias
proximal hypospadias presents a serious anomaly for both infants and their care givers. a variety of techniques were described through decades. None of them is completely curable.
- Trial name
- NCT06598215
- Testing
- Duckett urethroplasty
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Tanta University
Postoperative Pain, Hypospadias
Effect of Intravenous Dexamethasone With Pudendal Nerve Block on Postoperative Pain in Pediatric Hypospadias Repair
This study aims to determine if intravenous Dexamethasone combined with a pudendal nerve block is able to prolong postoperative analgesia in children undergoing hypospadias repair.
- Trial name
- NCT03902249
- Testing
- Dexamethasone
- Volunteers
- 70 people
- Sponsor
- Dr Sonia ben khalifa (PhD)
Post Operative Pain, Hypospadias
Comparison of Analgesic Efficacy of ESP Block and Caudal Block in Patients Undergoing Hypospadias Surgery
The goal of clinical trial is to compare in of analgesic efficacy of sacrale erector spinae plane (ESP) block and caudal block in participants undergoing hypospadias surgery.
- Trial name
- NCT05632536
- Testing
- SACRAL ESP AND CAUDAL BLOCK
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Hypospadias
Hypospadias and Exome: Identification of New Genes for Familial Hypospadias
Hypospadias is the second most common malformation of the male genitalia and consists in a congenital hypoplasia of its ventral face.
- Trial name
- NCT02495090
- Testing
- Exome sequencing
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Hypospadias, Penoscrotal
Preputial Graft Versus Preputial Flap in Treatment of Proximal Hypospadias With Marked Ventral Curvature (a Comparative Study)
Hypospadias is a male congenital anomaly characterized by the abnormally located urethral meatus being displaced along the ventral side of the penis along a line from the tip of glans penis to the perineum.
- Trial name
- NCT06165120
- Testing
- Bracka's repair using preputial graft, STPIF (Staged Transverse Preputial Island Flap) repair using preputial flap
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Urethrocutaneous Fistulas
2-octyl Cyanoacrylate for Closure of Urethrocutaneous Fistula.
Urethrocutaneous fistulae (UCF) represent one of the most frequent causes of morbidity after urethroplasty. Hypospadias can be repaired using different surgical techniques, but regardless of technique, the incidence of UCF ranges…
- Trial name
- NCT02115191
- Testing
- 2-octylcyanoacrylate, Surgical reintervention
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Instituto Mexicano del Seguro Social
Emergence Delirium, Intravenous Anesthesia
Sevoflurane and Intravenous Anesthesia in Hypospadias Repair
Emergence agitation (EA), a phenomenon observed at the time of recovery from general anesthesia (GA).The cause of ED appears to be multifactorial in origin.
- Conditions
- Emergence Delirium, Intravenous Anesthesia, Sevoflurane
- Trial name
- NCT06396468
- Testing
- sevoflurane, propofol
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Benha University
Anesthesia, General
The Effect of Anesthetics on Oxidative Stress and Apoptosis Status in Children
The purpose of this study is to determine whether Propofol and Sevoflurane affect the oxidative stress and apoptosis status in children undergoing hypospadias repair surgery.
- Trial name
- NCT02711280
- Testing
- Sevoflurane, Propofol
- Where
- China
- Volunteers
- 47 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hypospadias
Improving Parental Support in Hypospadias Care
The proposed study will enroll parent-child pairs and is designed to obtain new knowledge and improve hypospadias care. Parent-child pairs will be randomized into different groups over 36 months and participate for at least 6…
- Trial name
- NCT06832280
- Testing
- Educational Website Developed by Study Team, Basic Educational Website
- Where
- 2 sites in United States
- Volunteers
- 324 people
- Sponsor
- University of North Carolina, Chapel Hill
Distal Hypospadias, Hypospadias
Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias
Hypospadias is a common congenital condition in boys in which the opening of the urethra is located on the underside of the penis.
- Trial name
- FTIP-RCT (NCT07319780)
- Testing
- Fibrin-Enhanced TIP Urethroplasty, Grafted TIP Urethroplasty
- Where
- 2 sites in Indonesia, Uzbekistan
- Volunteers
- 100 people
- Sponsor
- National Children's Medical Center, Uzbekistan
Hypospadias, Anesthesia; Adverse Effect
The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA)
More than half a million children have an anaesthetic each year in the UK. Though anaesthesia is usually thought to be safe and necessary to improve health, concerns remain the effects that the drugs used may have on brain…
- Conditions
- Hypospadias, Anesthesia; Adverse Effect, Perioperative Complication, Pediatric ALL
- Trial name
- EPIVA (NCT05936853)
- Testing
- Intravenous approach to anaesthetic maintenance, Inhalational approach to anaesthetic maintenance
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Re-operative, Hypospadias
Re-operative Hypospadias Repair Using Tubularized Incised Plate Urethroplasty
The aim of this study is to evaluate the outcomes, feasibility, and complication profile of re-operative hypospadias repair using tubularized incised plate urethroplasty as a single-stage procedure in a single-center experience.
- Conditions
- Re-operative, Hypospadias, Tubularized Incised Plate, Urethroplasty
- Trial name
- NCT07424768
- Testing
- Tubularized Incised Plate Urethroplasty
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Tanta University
Hypospadias
Antibiotic Use in Distal Hypospadias Repair
Hypospadias is a common condition where the opening of the penis is not located at the tip, but along the underside of the penis. It is estimated to occur in 1/300 live male births, making it one of the most common birth defects.
- Trial name
- NCT03275519
- Testing
- Randomization to not receive prophylactic antibiotics after surgery., Randomization to receive prophylactic antibiotics after surgery
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Hypospadias
Redo Repair in Disrupted Hypospadias
Redo hypospadias repair is a challenging situation and its success depends on many factors. Several procedures could be used in such situations with variable outcomes.
- Trial name
- NCT06187363
- Testing
- Tubularized incised plate procedure, Other procedures
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Egyptian Biomedical Research Network
Distal Penile Hypospadias (Disorder)
Hybrid Mathieu Urethroplasty
the aim is to study the results of simple modification of classic Mathieu urethroplasty to increase the scope of cases candidates for that procedure.
- Trial name
- NCT04946058
- Testing
- hyebrid Mathieu Urethroplasty
- Volunteers
- 43 people
- Sponsor
- Tanta University
Pain
Dexmedetomidine Infusion in Hypospadias Surgery
The investigators hypothesize that giving Dexmedetomidine in combination with Fentanyl for pediatric patients undergoing hypospadias surgery, will reduce the fentanyl requirement for intraoperative and postoperative analgesia.
- Trial name
- NCT00926705
- Testing
- Dexmedetomidine and Fentanyl, Fentanyl
- Where
- Jordan
- Volunteers
- 48 people
- Sponsor
- University of Jordan
Concealed Penis, Hypospadias
A Prospective Registry of Patients With Congenital Penile Anomalies
Prospective registry and biobank in pediatric patients with congenital penile anomalies
- Conditions
- Concealed Penis, Hypospadias, Phimosis, Chordee
- Trial name
- NCT04755803
- Testing
- Penoplasty
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Seoul National University Hospital