Clinical trials: Penile Skin
Peyronies Disease
Platelet-Rich Plasma for Peyronie's Disease
The purpose of this clinical trial is to evaluate the effects of Platelet-Rich Plasma (PRP) intralesional injections in men affected by Peyronie's disease (PD) in the fibrotic phase.
- Trial name
- NCT07117955
- Testing
- Autologous Platelet Rich Plasma, Saline solution
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Herlev Hospital
Peyronies Disease
Treatment of Peyronie's Disease With Platelet-Rich Plasma
The purpose of this pilot study is to optimize a planned randomized, double-blind, placebo-controlled clinical trial evaluating the effects of Platelet-Rich Plasma (PRP) intralesional injections in men affected by Peyronie's…
- Trial name
- NCT06789510
- Testing
- Autologous Platelet Rich Plasma, Saline solution
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Herlev Hospital
Penile Cancer, Melanoma
Validation of ICG-99mTc-nanoscan as Hybrid Tracer for Sentinel Node Biopsy
99mTc-nanocolloid, the world wide used hybrid tracer for dynamic sentinel node biopsy, has recently been replaced with 99mTc-nanoscan.
- Conditions
- Penile Cancer, Melanoma, Oral Cancer
- Trial name
- NANOSCAN (NCT06666634)
- Testing
- Sentinel node biopsy with either ICG-99mTc-nanoscan or 99mTc-nanoscan
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- The Netherlands Cancer Institute
Peyronie Disease
Safety and Efficacy of Intralesional HiLow Hyaluronic Acid in the Treatment of Peyronie's Disease (PD)
Prospective, open-label, single-arm, multicentric, pilot clinical study to confirm the safety of HiLow hyaluronic acid sodium salt for intralesional penile injection in patients affected by PD.
- Trial name
- NCT05871177
- Testing
- Pre-filled syringe of HiLow Hyaluronic Acid Sodium Salt
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- IBSA Farmaceutici Italia Srl
Cancer
Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients
RATIONALE: Palliative care may help patients with advanced cancer live more comfortably. PURPOSE: This randomized clinical trial is studying an early intervention palliative care program to see how well it works compared to a…
- Trial name
- NCT00253383
- Testing
- counseling intervention, educational intervention, psychosocial assessment and care
- Where
- 2 sites in United States
- Volunteers
- 329 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Penis/Surgery, Penis/Injuries
Autologous Fat Grafting Beneath Penile Split Thickness Skin Graft Placement During Penile Reconstruction
The goal of this randomized interventional clinical trial is to learn if placement of a thin layer of fatty tissue (fat graft) beneath a split-thickness skin graft on the surface of the penis improved outcomes of surgery in men…
- Conditions
- Penis/Surgery, Penis/Injuries, Penile Skin, Adult-Acquired Buried Penis
- Trial name
- NCT07316491
- Testing
- Autologous fat grafting, Genitourinary Reconstruction with Split-Thickness Skin Grafting
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pittsburgh
Peyronie Disease
Non-ablative Radiofrequency and Low Intensity Shock Wave Therapy in Fibrotic Plaque in Men With Peyronie's Disease
The goal of this one arm clinical trial is to evaluate the safety and describe the clinical response of non-ablative radiofrequency treatment associated with shockwave therapy in men with Peyronie's disease.
- Trial name
- NCT06303661
- Testing
- Non-ablative Radiofrequency, Low-intensity Shock Wave Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Centro de Atenção ao Assoalho Pélvico
Peyronie's Disease
Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's Disease
Two recent studies have identified low levels of serum testosterone in association with Peyronie's Disease (PD), with a significant correlation noted between severity of testosterone deficiency and severity of curvature.
- Trial name
- PD+ (NCT01578473)
- Testing
- Vitamin D2, Vitamin E, Testosterone Pellets
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Men's Health Boston
Peyronies Disease
Fractionated Carbon Dioxide Laser Therapy for Treatment of Peyronie's Disease
This is a pilot study that evaluates the use of Fractional Carbon Dioxide Laser Therapy in the treatment of Peyronie's Disease. Study participants will be assigned to receive Fractional Carbon Dioxide Laser Therapy at 10-15%…
- Trial name
- NCT04326465
- Testing
- Fractional Carbon Dioxide Laser Therapy at 10-15% Laser Density Coverage
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
Stress, Job, PTSD
The Sequestration of Holistic Stress Management Techniques for Adults
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life.
- Conditions
- Stress, Job, PTSD, Hypervigilance, Hyperthyroidism
- Trial name
- NCT06098755
- Testing
- Holistic Medicine (HM)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Goddess Zena I. Jones
Advanced Malignant Solid Neoplasm, Carcinoma of Unknown Primary
Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic
This phase II trial studies how well pembrolizumab works in treating patients with rare tumors that cannot be removed by surgery or have spread to other parts of the body.
- Conditions
- Advanced Malignant Solid Neoplasm, Carcinoma of Unknown Primary, Metastatic Adrenal Gland Pheochromocytoma, Metastatic Kidney Medullary Carcinoma
- Trial name
- NCT02721732
- Testing
- Laboratory Biomarker Analysis, Pembrolizumab, Questionnaire Administration
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer, Vulvar Cancer
Education, Immigration and HPV Vaccination: an Informational Randomized Trial
Counteracting misinformation on childhood vaccines remains a priority for public health in industrialized countries. Previous research showed that misinformation-induced vaccine hesitancy particularly concerns very highly or very…
- Conditions
- Cervical Cancer, Vulvar Cancer, Anus Cancer, Penis Cancer
- Trial name
- NCT04905030
- Testing
- Information T1, Information T2, Information C
- Where
- Sweden
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Peyronie's Disease
Real-World Data Study to Understand Effectiveness of Treatments in Peyronie's Disease
This is an observational study, meaning participants will not receive any investigational treatment as part of this study. Researchers will collect real-world data (RWD) to gain a more in-depth knowledge of the treatment of…
- Trial name
- CURVE-PD (NCT05873595)
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Cervical Cancer, Esophageal Cancer
Isotretinoin Plus Interferon in Treating Patients With Recurrent Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of isotretinoin may be an effective way to prevent cancer or stop cancer from growing.
- Conditions
- Cervical Cancer, Esophageal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00002506
- Testing
- recombinant interferon alfa, isotretinoin
- Where
- 6 sites in United States
- Sponsor
- Hoag Memorial Hospital Presbyterian
Peyronie's Disease
Efficacy of a Novel CCH Protocol for PD Among Prior Non-responders
Compare key clinical outcomes between controls and men treated with a novel CCH administration protocol among men previously unresponsive to CCH administration.
- Trial name
- NCT05108558
- Testing
- CCH administration, Control - Crossover to CCH, RestoreX
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Charitable Union for the Research and Education of Peyronie's Disease
Peyronie's Disease (PD)
Comparative Outcomes of Subtunical Microdissection and Grafting Versus Classical Plaque Incision and Grafting in Complex Peyronie's Disease
The goal of this clinical study is to compare two surgical techniques used for the treatment of complex Peyronie's disease. Peyronie's disease can cause penile curvature, deformity, and difficulties during sexual intercourse due…
- Trial name
- Peyronie (NCT07470528)
- Testing
- Subtunical microdissection and grafting, Classic plaque Incision and Grafting
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Peyronie's Disease, Hyaluronic Acid
Intralesional Hyaluronic Acid and Verapamil Injection in Peyronie's Disease
The aim of the present study is to investigate whether intralesional injections of Hyaluronic acid in the acute phase could reduce the progression of Peyronie's disease thanks to its interference with inflammatory and…
- Conditions
- Peyronie's Disease, Hyaluronic Acid, Verapamil
- Trial name
- NCT05855070
- Testing
- Intralesional treatment with Hyaluronic acid, Intralesional treatment with Verapamil
- Volunteers
- 42 people
- Sponsor
- Benha University
Peyronie's Disease
A Phase 3, Open-label Study of the Safety and Effectiveness of AA4500 Administered Twice Per Treatment Cycle for up to Four Treatment Cycles (2 x 4) in Men With Peyronie's Disease
This study is a Phase 3, open-label study of the safety and efficacy of AA4500 0.58 mg in subjects with Peyronie's disease. Subjects will be screened for study eligibility within 21 days before the initial injection of study drug…
- Trial name
- NCT01685437
- Testing
- AA4500
- Volunteers
- 189 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Carcinoma, Renal Cell, Head and Neck Neoplasm
Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types
This is a Phase 2, non-randomised, open-label, multicentric study to investigate the efficacy and safety of nivolumab monotherapy in 6 cohorts of patients with specific rare cancers who have unresectable locally advanced or…
- Conditions
- Carcinoma, Renal Cell, Head and Neck Neoplasm, Skin Neoplasms, Microsatellite Instability
- Trial name
- AcSé (NCT03012581)
- Testing
- Nivolumab
- Where
- France
- Volunteers
- 269 people
- Sponsor
- UNICANCER