Clinical trials: People Who Inject Drugs
Drug Use, Hepatitis
Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries
Implementation and evaluation of a distribution program for low dead-space syringes/needles (LDSS/N) in Armenia, Georgia, and Tanzania, Egypt, Nigeria, Vietnam, India, Ukraine, and South Africa.
- Conditions
- Drug Use, Hepatitis, Hiv
- Trial name
- NCT06395129
- Testing
- Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test
- Where
- 9 sites in Armenia, Georgia and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
HIV Infections
Advancing Access to HIV/HCV Testing for People Who Inject Drugs (PWID)
The purpose of this study is to test the effectiveness of the ACCESS strategy: an organizational-level intervention that uses funding and practice facilitation to improve the organizational capacity of syringe services programs…
- Trial name
- ACCESS (NCT06730555)
- Testing
- ACCESS Intervention, Control Group
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Miami
Peer Support, Injection-related Infections
The Injection-Related InfectionS (IRIS) Program
People who inject drugs are at risk of injection-related infections, like abscesses or infective endocarditis. The Injection-Related InfectionS (IRIS) program hopes to improve treatment for participants by providing a…
- Conditions
- Peer Support, Injection-related Infections, Infections, People Who Infect Drugs (PWID)
- Trial name
- IRIS (NCT06169553)
- Testing
- Holistic injection-related injection treatment
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Harm Reduction, HIV Infections
Implementation of Onsite, Rapid ART Initiation Among People Who Inject Drugs Living With HIV at Syringe Services Program
The purpose of this study is to see if providing HIV medicine right away at the IDEA Syringe Services Program will help the participant start and remain in HIV care, including having no detectable HIV in the participant's blood.
- Conditions
- Harm Reduction, HIV Infections, Drug Use
- Trial name
- NCT04650269
- Testing
- Biktarvy 50Mg-200Mg-25Mg Tablet, HIV care
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Human Immunodeficiency Virus, Substance Abuse, Intravenous
BRIDGE: Improving HIV Service Delivery for People Who Inject Drugs
Scaling up integrated, cost-efficient HIV services for people who inject drugs (PWID) in Needle Syringe Programs (NSPs) is urgently needed in Kazakhstan, where only one-third of the estimated 19,000 HIV-positive PWID are ever…
- Trial name
- NCT02796027
- Testing
- BRIDGE
- Where
- 2 sites in United States, Kazakhstan
- Volunteers
- 616 people
- Sponsor
- Columbia University
HIV Prevention
Adaptive Intervention Strategies for HIV PrEP Care in Rural People Who Inject Drugs
During this 5-year study, stepped-care adaptive interventions will be deployed in three rural syringe service programs in a Sequential Multiple Assignment Randomized Trial (SMART) design to test the optimal intervention pathways…
- Trial name
- NCT06666309
- Testing
- SBCM-PrEP + Text Messaging, CDC-PrEP + Text Messaging, T-SBCM
- Where
- 4 sites in United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Hilary L Surratt, PhD
HIV
A Social Network Approach for Improving Medication Assisted Treatment and HIV Prevention and Medical Care Among People Who Inject Drugs in Ukraine
The aim of this study is to pilot a peer education for people on medication assisted treatment (MAT). People on MAT will be trained to be peer educators and provide outreach to the educators social network members who inject…
- Trial name
- NCT05824702
- Testing
- Peer education & communications, Standard of care educational
- Where
- Ukraine
- Volunteers
- 241 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cognitive Dysfunction
Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs
The goal of this pilot work was to determine if the cognitive dysfunction accommodation strategies help patients retain/utilize more HIV prevention information and increase PrEP adherence.
- Trial name
- NCT05912374
- Testing
- standard Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB), enhanced Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Hepatitis C, Chronic, Substance Use Disorders
Evaluating the Chain of Addiction Care (CAC)
The investigators want to evaluate the feasibility of a decentralised hepatitis C care pathway (the Chain of Addiction Care (CAC) pathway) in several addiction care centres in the east of the Netherlands.
- Trial name
- HepC:CAC (NCT05401136)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Radboud University Medical Center
Hepatitis C
ETHOS ENGAGE: Enhancing Treatment of Hepatitis C in Opioid Substitution Settings
The overall goals of the ETHOS II Project are to enhance hepatitis C virus (HCV) care in drug treatment clinics and needle and syringe programs (NSPs) in New South Wales and Australia, and to develop a translational framework for…
- Trial name
- ETHOS II (NCT03685045)
- Testing
- Campaign days
- Where
- 32 sites in Australia
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
HIV Infections, HCV
The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City
The goal of this pilot clinical trial is to learn if an intervention that trains Gancheros (people who provide injection services in exchange for drugs or money) to conduct risk-reduction outreach could help lower risk for human…
- Conditions
- HIV Infections, HCV, Overdose
- Trial name
- NCT06316739
- Testing
- Ganchero intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI)
HIV
EPIC-P Intervention
This non-randomized, open-label study will address the following research aims in People who inject drugs (PWID): To assess the feasibility and acceptability of the Expanding PrEP Implementation in Communities of PWID (EPIC-P)…
- Trial name
- NCT04193787
- Testing
- EPIC-P
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Connecticut
HIV Antibody Positivity, PrEP Uptake
PrEP for Prevention of HIV Transmission Among People Who Inject Drugs in Nairobi, Kenya
The investigators broadly aim at determining barriers and facilitators to PrEP uptake and adherence and retention among the study participants.
- Trial name
- NCT05465265
- Testing
- Navigation into prEP by use of PrEP-UP intervention (provision of PrEP information through 5 counselling sessions, peer support, booking of appointments for PWIDs)
- Where
- Kenya
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hepatitis C, Medication Adherence
Patient-Centered Models of HCV Care for People Who Inject Drugs
People who inject drugs (PWID) have higher rates of hepatitis C virus (HCV) than do other groups. Effective, safe new treatments called direct-acting antiviral agents (DAAs) have been developed recently.
- Trial name
- HERO (NCT02824640)
- Testing
- Patient Navigation, modified Directly Observed Therapy
- Where
- United States
- Volunteers
- 755 people
- Sponsor
- Prisma Health-Upstate
HIV Prevention, HCV
Integrated HIV Prevention and HCV Care for PWID
The objective of this study is to compare and evaluate two strategies of delivering PrEP and Hepatitis C Virus (HCV) treatment to people who inject drugs to determine the best method of providing care.
- Conditions
- HIV Prevention, HCV, Opioid Use, Intravenous Drug Usage
- Trial name
- M2HepPrEP (NCT03981445)
- Testing
- ARTAS Adapted Patient Navigation, Adherence Counseling
- Where
- 3 sites in United States, Canada
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- Columbia University
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
HIV Viremia
Optimizing a Bio-behavioral Intervention for Sustained Viral Suppression
The study will test two behavioral intervention components to identify the combination of the two components that best supports people who inject drugs to achieve and sustain HIV viral load suppression.
- Trial name
- NCT05377463
- Testing
- Peer support to promote uptake and persistence of medication assisted treatment (MAT), Behavioral Activation Treatment (BAT) to reduce depression, No Intervention Components
- Where
- Mexico
- Volunteers
- 220 people
- Sponsor
- University of Texas, El Paso
HIV Infections, HCV
A Setting Focus Overdose Prevention Intervention
A pilot injection-setting targeted peer-driven intervention to reduce HIV and hepatitis C virus transmission and overdose risk behaviors among people who inject drugs (PWID).
- Conditions
- HIV Infections, HCV, Drug Overdose
- Trial name
- Oasis (NCT05320835)
- Testing
- HIV, HCV and overdose prevention
- Where
- United States
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hepatitis C, Intravenous Drug Users
Accelerated Pre-treatment Evaluation for HCV Infected Persons Who Inject Drugs
Persons who inject drugs (PWID) are overrepresented among hepatitis C infected patients, but underrepresented among those who are treated, despite many studies showing that treatment is feasible and effective in this population.
- Trial name
- NCT02755402
- Testing
- Xpert HCV Viral load, Transient elastography
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
HIV, Opioid Dependence
Study of Integrating Antiretroviral Therapy With Methadone Treatment for People Who Inject Drugs
To improve ART initiation among people who inject drugs, the investigators propose to develop and pilot a multi-component Integrated Methadone and Antiretroviral Therapy strategy (IMAT) in Dar es Salaam, Tanzania.
- Trial name
- IMAT (NCT02167425)
- Testing
- IMAT
- Volunteers
- 800 people
- Sponsor
- Pangaea Global AIDS Foundation