Clinical trials: Peptic Ulcer Bleeding
Upper Gastrointestinal Bleeding
Anticoagulation With Enhanced Gastrointestinal Safety (AEGIS) Trial
This is a pragmatic, single center, feasibility pilot cluster randomized trial with embedded individual randomization to evaluate implementation strategies to increase the use of evidence-based practices to reduce upper…
- Trial name
- AEGIS (NCT05085405)
- Testing
- Clinician notification, Clinician Notification with Nurse Facilitation, Clinician Notification / Patient Activation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Peptic Ulcer Hemorrhage
Precise Delivery of Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding
Peptic ulcer bleeding is a common emergency for patients who need therapeutic endoscopy. According to international guidelines and Taiwan consensus, the standard therapy included proton pump inhibitor (PPI) and endoscopic…
- Trial name
- NCT05248321
- Testing
- Tranexamic Acid Powder
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Peptic Ulcer Hemorrhage
China Survey of Peptic Ulcer Bleeding
This will be a multicenter prospective observational study carried out in China. The investigators will collect data in a pre-specified Case Report Form.
- Trial name
- PUB (NCT01241266)
- Where
- 31 sites in China
- Volunteers
- 1,044 people
- Sponsor
- AstraZeneca
Ulcer Bleeding, Upper Gastrointestinal Tract Bleeding
The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers
Non-variceal acute gastrointestinal bleeding is a common and potentially life-threatening problem. The conventional treatment of this condition is for esophagogastroduodenoscopy (OGD) for haemostasis.
- Trial name
- NCT03160911
- Testing
- Over-the-scope clip (OTSC), Conventional Endoscopic Haemostasis
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Peptic Ulcer Hemorrhage
The Selection Criteria for the Second-look Endoscopy Among Patients With Bleeding Peptic Ulcers
The purpose of this prospective study is to identify risk factors which could predict poor fading of SRH or early recurrent bleeding of peptic ulcer hemorrhage after successful endoscopic hemostasis and high-dose PPI infusion.
- Trial name
- CSE (NCT02197039)
- Testing
- esomeprazole or pantoprazole, Endoscopic hemostasis
- Where
- Taiwan
- Volunteers
- 316 people
- Sponsor
- National Cheng-Kung University Hospital
Bleeding Peptic Ulcers Disease
Optimal Dose of Omeprazole After Endoscopic Treatment of Bleeding Peptic Ulcers
Bleeding peptic ulcers are one of the major causes of morbidity and mortality for hospital emergency admissions.The initial treatment is endoscopic therapy followed by intravenous omeprazole.
- Trial name
- NCT00519519
- Testing
- Omeprazole
- Where
- 4 sites in Singapore
- Volunteers
- 126 people
- Sponsor
- Singapore General Hospital
Peptic Ulcer Hemorrhage
Ilaprazole for the Treatment and Prevention of Peptic Ulcer Bleeding in Chinese Patients
The purpose of this phase study is to confirm the efficacy and safety by compare ilaprazole and omeprazole in the treatment and prevention of peptic ulcer bleeding.
- Trial name
- NCT03362281
- Testing
- Ilaprazole, Omeprazole, Ilaprazole tablet
- Volunteers
- 540 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage
Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
We prepare this study to compare the efficacy of intermittent intravenous PPI infusion (relatively low dose PPI therapy) than continous PPI infusion method.
- Conditions
- Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage, Peptic Ulcer, Proton Pump Inhibitor Overdose
- Trial name
- NCT03814421
- Testing
- intermittent (40mg as a bolus injection daily for 72hours)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Changwon Hospital
Peptic Ulcer, Hemorrhage
Rapid Urease Test for Diagnosis of H. Pylori Infection in Patients With Peptic Ulcer Bleeding
Rapid urease test (RUT) is the most commonly used biopsy-based method to diagnose Helicobacter pylori (Hp) infection because of its simple, rapid and accurate characters.
- Trial name
- NCT01282853
- Testing
- endoscopic biopsy
- Where
- Taiwan
- Volunteers
- 116 people
- Sponsor
- Far Eastern Memorial Hospital
Peptic Ulcer Bleeding
Risk Factors of Rebleeding After Peptic Ulcer Bleeding: a Nationwide Cohort Study
The purpose of the investigators study is to investigate the factors associated with rebleeding in patients with peptic ulcer bleeding.
- Trial name
- KPUB (NCT02152904)
- Where
- South Korea
- Volunteers
- 892 people
- Sponsor
- Joon Sung Kim
Gastroduodenal Ulcer, Marginal Ulcer
Efficacy of Low Dose of Proton Pump Inhibitor in Treatment Bleeding Ulcers
Determining the efficacy of low dose of PPI in management acute peptic ulcer bleeding
- Conditions
- Gastroduodenal Ulcer, Marginal Ulcer, Peptic Ulcer Hemorrhage
- Trial name
- NCT03163680
- Testing
- Omeprazole 40 MG
- Where
- Syria
- Volunteers
- 295 people
- Sponsor
- Damascus Hospital
Gastric Ulcer, Duodenal Ulcer
Comparison of Ulcer Healing in Patients Taking Rabeprazole With Different Antiplatelets
Clopidogrel causes significantly less peptic ulcer disease (PUD) and ulcer bleeding than low-dose aspirin in general population.
- Trial name
- NCT01037491
- Testing
- rabeprazole plus aspirin versus rabeprazole plus clopidogrel
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Peptic Ulcer
PPI vs H2RA in Patients With Helicobacter Pylori-Negative Idiopathic Bleeding Ulcers
The aim of this study is to compare the efficacy of a proton pump inhibitor (lansoprazole) and a histamine-2 receptor antagonist (famotidine) in preventing recurrent ulcer bleeding in patients with a history of H.
- Trial name
- NCT01180179
- Testing
- Lansoprazole, Famotidine
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Chinese University of Hong Kong
Bleeding Peptic Ulcer
Surveillance of Bleeding Peptic Ulcer Using Wireless Capsule Endoscopy
To investigate the adjunctive role of "Capsule Endoscope" in continuous endoscopic monitoring and early detection of recurrent ulcer bleeding after endoscopic therapy in patients presenting with bleeding peptic ulcers
- Trial name
- NCT00164827
- Testing
- Endoscopic placement of Capsule endoscope adjacent to the peptic ulcer
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Bleeding, Peptic Ulcer
Early Selective TAE to Severely Bleeding Peptic Ulcers After Their Initial Endoscopic Hemostasis
The aim of this study is to determine if early angiographic embolization can forestall recurrent bleeding in selected high risk ulcers after their initial endoscopic control; to validate prospectively the investigators proposed…
- Conditions
- Bleeding, Peptic Ulcer, Arterial Embolization
- Trial name
- NCT01142180
- Testing
- TAE, No TAE
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Chinese University of Hong Kong
Peptic Ulcer Hemorrhage
Helicobacter Pylori Empiric Treatment in Ulcer Bleeding
The goal of the study is to compare the effectiveness of empirical Helicobacter pylori treatment compared with treatment depending on diagnostic tests for Helicobacter pylori in patients with Upper gastrointestinal bleeding due…
- Trial name
- HETUB (NCT00687336)
- Testing
- Empirical Hp eradication, Eradication treatment guided by a positive test
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Hospital de Sabadell
Upper Gastrointestinal Bleeding
Oral vs Intravenous and Proton Pump Inhibitor (PPI）for Peptic Ulcer Bleeding (PUB)
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01123031
- Testing
- lansoprazole, esomeprazole
- Sponsor
- Changhua Christian Hospital
Peptic Ulcer Bleeding
Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
The investigators used two different doses of esomeprazole (40 mg IV q.d. and 40 mg IV q6h for three days followed by esomeprazole 40 mg q.d.
- Trial name
- lowdosePPI (NCT04407832)
- Testing
- heat probe or hemoclip
- Where
- Taiwan
- Sponsor
- Changhua Christian Hospital
Peptic Ulcer
Esomeprazole Versus Pantoprazole to Prevent Peptic Ulcer Rebleeding
The aim of this study is to compare the clinical effectiveness of intravenous esomeprazole and pantoprazole in preventing recurrent bleeding in the patients with high-risk bleeding peptic ulcers after successful standard…
- Trial name
- NCT00881413
- Testing
- Esomeprazole, Pantoprazole
- Sponsor
- Lotung Poh-Ai Hospital
Upper Gastrointestinal Bleeding
UI-EWD for Endoscopic Hemostasis of Bleeding Peptic Ulcers and Bleeding After EMR/ESD
UI-EWD (NextBiomedical Co, Incheon, South Korea), a new hemostatic powder for endoscopic treatment of high-risk bleeding peptic ulcers and bleeding after ESD/EMR.
- Trial name
- NCT02978391
- Testing
- UI-EWD Hemostatic system, epinephrine endoscopic injection (conventional therapy)
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Next Biomedical Co., Ltd.