Clinical trials: Percutaneous Coronary Intervention Patients
Myocardial Infarction, Statin Adverse Reaction
Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI
Combination therapy of rosuvastatin 5mg and ezetimibe 10 mg showed similar achievement rate in decreasing LDL cholesterol level by 50% as single use of rosuvastatin 20 mg.
- Conditions
- Myocardial Infarction, Statin Adverse Reaction, HMG-CoA Reductase Inhibitor Toxicity
- Trial name
- ROSUZET-AMI (NCT04499859)
- Testing
- Ezetimibe 10mg + Rosuvastatin 5mg, Rosuvastatin 20mg
- Where
- 7 sites in South Korea
- Volunteers
- 3,548 people
- Sponsor
- Kiyuk Chang, MD,PhD
Obstructive Sleep Apnea, Diabetes Mellitus
Rapid Eye Movement Related OSA in Diabetic Versus Non-Diabetic Patients Treated With PCI
The primary objective of the Sleep and Stent II is to determine the prevalence of REM-OSA in DM versus non-DM patients undergoing clinically indicated PCI.
- Conditions
- Obstructive Sleep Apnea, Diabetes Mellitus, Coronary Artery Disease
- Trial name
- NCT03479788
- Where
- Singapore
- Volunteers
- 204 people
- Sponsor
- National University of Singapore
Coronary Artery Disease, Percutaneous Coronary Intervention
The Efficacy, Safety and Pharmacokinetic of Antiplatelet Therapy for Vicagrel
This is a multi-center, randomized, double-blind, triple-dummy, parallel-controled, dose-exploration phase II trial. Patients with coronary atherosclerotic heart disease and planned percutaneous coronary intervention （PCI） will…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors
- Trial name
- NCT03599284
- Testing
- Vicagrel 5mg, Vicagrel 6mg, Vicagrel 7.5mg
- Where
- 27 sites in China
- Volunteers
- 279 people
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Periprocedural Myocardial Injury, Coronary Artery Disease
Prognostic Impact of PMI in Stable CAD Undergoing PCI
This is a single-center, observational, prospective study. This study aims to observe the effect of periprocedural myocardial injury on cardiovascular events in patients undergoing elective percutaneous coronary intervention, and…
- Conditions
- Periprocedural Myocardial Injury, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT04239404
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Coronary Syndrome
High On-treatment Platelet Reactivity Identified by Multiple Platelet Function Assay
High on-treatment platelet reactivity to adenosine diphosphate was a important reason to cause ischemic events in antiplatelet therapy.
- Trial name
- HOPEmultiPFA (NCT02699008)
- Testing
- Clopidogrel, Ticagrelor
- Where
- China
- Volunteers
- 477 people
- Sponsor
- Wuhan Asia Heart Hospital
Coronary Disease
Reduced Anti-Platelet Therapy With Pimecrolimus Drug Eluting Stent (RAPID)
Non-randomized, single arm, multi-center, clinical trial evaluating the Corio™ pimecrolimus-eluting stent with reduced anti-platelet therapy in patients with de novo lesions of the native coronary arteries.
- Trial name
- NCT00322543
- Testing
- Corio™ Pimecrolimus-eluting stent
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- Conor Medsystems
Non-ST Elevation Acute Coronary Syndrome
Ticagrelor vs Clopidogrel in Non-ST Elevation Acute Coronary Syndrome Patients Undergoing PCI With Bivalirudin.
The purpose of this study is to determine if ticagrelor is as effective as clopidogrel in rate of onset and degree of platelet inhibition for patients with non-ST elevation of acute coronary syndrome (NSTE-ACS) undergoing ad hoc…
- Trial name
- NSTE-ACS (NCT02052635)
- Testing
- ticagrelor, clopidogrel
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- AstraZeneca
Ischemic Heart Disease, Acute Coronary Syndromes
Effects of Atorvastatin Versus Pravastatin on Platelet Inhibition by Clopidogrel
Clopidogrel and statins are frequently coadministered in patients with ischemic heart diseases. Recent reports suggested that clopidogrel's effectiveness in inhibiting adenosine diphosphate (ADP)-induced platelets aggregation is…
- Trial name
- NCT00405717
- Testing
- atorvastatin,pravastatin
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Shenyang Northern Hospital
ST-Elevation Myocardial Infarction
Deferred Stent Trial in STEMI
During primary PCI, stent deployment and post-dilatation are associated with no-reflow. The mechanisms for no reflow include distal embolization of thrombus, enhanced thrombus formation and vascular spasm.
- Trial name
- NCT01717573
- Testing
- Deferred stenting, Conventional treatment
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- NHS National Waiting Times Centre Board
Obstructive Sleep Apnea
Sleep and Stent Study: a Multicentre, Prospective Study
Elucidating the effects of obstructive sleep apnea (OSA) on cardiovascular outcomes is crucial in risk assessments and therapeutic recommendations for affected individuals.
- Trial name
- NCT02215317
- Where
- Singapore
- Volunteers
- 1,815 people
- Sponsor
- National University of Singapore
Coronary Artery Disease, End Stage Renal Disease
Coronary Revascularization in Patients On Dialysis in China-Retrospective Registry
Coronary artery disease (CAD) is the leading cause of death in end-stage renal disease (ESRD) patients requiring dialysis. There are limited data on clinical characteristics, treatment strategies and outcomes in this special…
- Conditions
- Coronary Artery Disease, End Stage Renal Disease, Dialysis
- Trial name
- CRUISE-R (NCT05841082)
- Where
- China
- Volunteers
- 1,249 people
- Sponsor
- China-Japan Friendship Hospital
Acute Kidney Injury
Tailored Hydration Based on Bioimpedance Analysis for Prevention of Contrast Induced Acute Kidney Injury
The aim of this study was to evaluate, in patients with "normal fluid status" assessed by the bio-impedance analysis, whether two different protocol of IV isotonic saline infusion are associated with different volume expansion…
- Trial name
- Hydra2 (NCT04215042)
- Testing
- sodium chloride infusion
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Ospedale Misericordia e Dolce
MACE, In STEMI
"Short-term Outcome in STEMI Patients Undergoing Primary PCI: A Comparative Study Between Rural and Urban Communities at Assiut University."
this study aims to assess the short-term (3-month) clinical and echocardiographic outcomes of primary PCI among STEMI patients from rural versus urban areas in Upper Egypt.
- Trial name
- NCT07136831
- Testing
- Primary Percutaneous Coronary Intervention (PPCI)
- Volunteers
- 162 people
- Sponsor
- Assiut University
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Canada Satellite Registry
For the majority of Coronary Artery Disease (CAD), treatment with Percutaneous Transluminal Coronary Angioplasty (PTCA) provides high initial procedural success.
- Trial name
- NCT01880242
- Where
- 2 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Biotronik Canada Inc
Coronary Artery Disease, Diffuse Coronary Artery Disease
Hybrid Percutaneous Coronary Intervention Combining a Bioresorbable Scaffold With Drug-coated Balloons Versus a Conventional Drug-eluting Stent-based Strategy in Patients With Long and Diffuse Coronary Artery Disease
The primary objective of the study is to assess the safety and the efficacy of a hybrid percutaneous coronary intervention (PCI) strategy combining a magnesium-based sirolimus-eluting bioresorbable scaffold (Freesolve, Biotronik…
- Conditions
- Coronary Artery Disease, Diffuse Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
- Trial name
- BIOHYBRID (NCT06710210)
- Testing
- PCI with a bioresorbable scaffold and drug-coated balloon(s), PCI with drug-eluting stent(s)
- Where
- 4 sites in Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Geneva
Cardiac Arrest, Out-Of-Hospital, Angiography
Direct or Subacute Coronary Angiography in Patients With Out of Hospital Cardiac Arrest Without Coma.
In patients with Out-of-Hospital Cardiac arrest who achieves Return Of Spontaneous Circulation (ROSC) The investigators want to evaluate whether there is a benefit from acute Angiography compared to subacute (12-24 hours)…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Angiography, Percutaneous Coronary Intervention, Coma
- Trial name
- DISCO-noCOMA (NCT04876222)
- Testing
- Acute CAG
- Where
- 7 sites in Denmark, Netherlands
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital Skejby
Coronary Disease, Angina, Unstable
Abciximab, Clopidogrel and Percutaneous Coronary Intervention in Acute Coronary Syndrome (ISAR-REACT-2)
The purpose of this study is to determine whether there is any additional benefit from abciximab administration during percutaneous coronary intervention in patients presenting with acute coronary syndromes after pre-treatment…
- Trial name
- NCT00133003
- Testing
- Abciximab
- Where
- 5 sites in Brazil, Germany and 1 more
- Volunteers
- 2,022 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Chronic Total Occlusion of Coronary Artery
Revascularization Versus Optimal Medical Therapy of Chronic Total Coronary Occlusions on Left Ventricular Ischemia Reduction
Rationale: Randomized trials could not yet establish favourable outcomes of CTO PCI on hard endpoints such as ejection fraction or mortality, when compared to optimal medical therapy.
- Trial name
- REVISE-CTO (NCT03756870)
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Coronary Insufficiency, Smoking
Coagulation Profile in Patients Undergoing Coronary Angiography and Percutaneous Coronary Intervention
The activated clotting time (ACT), global thrombosis test (GTT-3), platelet inhibition P2Y12 (VerifyNow) test and serum coagulation factors will be measured in patients undergoing coronary angiography (CA) and percutaneous…
- Trial name
- GlobalACT (NCT05336669)
- Volunteers
- 40 people
- Sponsor
- Centre of Postgraduate Medical Education
ST Segment Elevated Myocardial Infarction
Early rhBNP on Myocardial Remodeling and Reperfusion in Patients With STEMI
The study intends to evaluate the efficacy of early rhBNP on myocardial remodeling and reperfusion in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention
- Trial name
- NCT04033861
- Testing
- rhBNP, Control
- Where
- China
- Volunteers
- 352 people
- Sponsor
- RenJi Hospital