Clinical trials: Percutaneous Coronary Revascularization
Percutaneous Coronary Intervention
3D Printed Silicone Coronary Artery Simulator for Percutaneous Coronary Interventional Training
This study is aim to evaluate the feasibility and effectiveness of 3D printed silicone coronary artery simulator for percutaneous coronary interventional training.
- Trial name
- 3DforPCI (NCT04420715)
- Testing
- Training on coronary angiography using 3D coronary artery simulator
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Chronic Total Occlusion (CTO)
Feasibility of a Cardiac Rehabilitation Program for CTO Patients Before PCI Treatment
The goal of this clinical trial is to evaluate the feasibility of a cardiac pre-hab program for patients with blocked arteries (CTO) who are referred for PCI treatment.
- Trial name
- PREHAB-CTO (NCT06610708)
- Testing
- Cardiac Prehabilitation Program
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Luiz Ybarra
Coronary Artery Disease
Bioflow-DAPT Study
BIOFLOW-DAPT is a prospective, multi-center, international, two-arm randomized controlled clinical study. A total of 1'948 subjects will be randomized 1:1 to receive either Orsiro Mission or Resolute Onyx.
- Trial name
- NCT04137510
- Testing
- Percutaneous coronary intervention
- Where
- 53 sites in Australia, Austria and 16 more
- Volunteers
- 1,948 people
- Sponsor
- Biotronik AG
Percutaneous Coronary Intervention, Intravenous Ultrasound
IVUS-FFR Accuracy for Coronary Stenosis
IVUS-FFR Online Accuracy for Coronary Stenosis What is this study testing? This study is testing a new technology called IVUS-FFR , which uses ultrasound imaging inside heart arteries (IVUS) to quickly measure whether a narrowed…
- Conditions
- Percutaneous Coronary Intervention, Intravenous Ultrasound, Coronary Physiology
- Trial name
- IVUS-FFR (NCT07446023)
- Testing
- Ultrasound-Derived Fractional Flow Reserve Computational System
- Where
- China
- Volunteers
- 292 people
- Sponsor
- China National Center for Cardiovascular Diseases
Thrombosis
CASTLE (Clopidogrel And Serum Troponin Level Elevation)
Primary Objective: To test if 600 mg of clopidogrel loading dose administered ≥ 6 and ≤ 24 hours prior to PCI produce a greater decrease of periprocedural release of biochemical markers (CK, CK-MB, and troponin-T and/or I) of…
- Trial name
- CASTLE (NCT00716924)
- Testing
- Clopidogrel
- Where
- Mexico
- Volunteers
- 155 people
- Sponsor
- Sanofi
Coronary Artery Disease, Angioplasty, Transluminal, Percutaneous Coronary
Safety Study to Assess the FEasibility of Use of the TRYTON Bifurcation Coronary Stent System (SAFE-TRY)
To assess the safety and feasibility of the use of the Tryton bifurcation coronary stent system for the treatment of single de novo bifurcation lesions in native coronary arteries.
- Trial name
- SAFE-TRY (NCT01174433)
- Testing
- Tryton
- Where
- 6 sites in Italy
- Volunteers
- 241 people
- Sponsor
- University of Padova
Coronary Artery Disease, Myocardial Ischemia
Role of Plavix in Hemorrhagic and Ischemic Complications of Catheterization.
Patients who have stents placed in their coronary arteries require treatment with at least two medications to prevent platelets from sticking to the stainless steel stent and forming a blood clot that can result in a heart…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Bleeding
- Trial name
- NCT00421252
- Testing
- clopidogrel 600 mg, arterial access sheath
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Beth Israel Deaconess Medical Center
Coronary Artery Disease
PRECISION GRX Post-Market Study - Japan
To collect data on the routine patterns of use, safety and effectiveness, including the clinical and technical performance of the CorPath GRX System, in the delivery and manipulation of coronary guidewires and stent/balloon…
- Trial name
- NCT03870087
- Testing
- Robotic-assisted PCI
- Where
- 8 sites in Japan
- Volunteers
- 242 people
- Sponsor
- Siemens Healthineers Endovascular Robotics, Inc.
Percutaneous Coronary Intervention
Comparative Registry of the PROmus™, ENdeavor™ and CYpher™ Drug Eluting Stents
The purpose of this study is to collect real-life data of the Promus™ stent, the Cypher™ stent and the Endeavor™ stent in routine clinical practice, and compare outcomes.
- Trial name
- ProEnCy (NCT00930878)
- Testing
- Cardiac Stenting
- Where
- Germany
- Volunteers
- 1,934 people
- Sponsor
- Boston Scientific Corporation
Ischemic Heart Disease
Prognostic Perspective of Invasive Hyperemic and Non-Hyperemic Physiologic Indices Measured After Percutaneous Coronary Intervention
Coronary physiologic assessments by the pressure-derived fractional flow reserve (FFR) have become standard methods for identifying hemodynamic deprivation in coronary arterial stenosis for evidence-based percutaneous coronary…
- Trial name
- PERSPECTIVEPCI (NCT04265443)
- Testing
- Percutaneous coronary intervention
- Where
- 5 sites in South Korea
- Volunteers
- 588 people
- Sponsor
- Samsung Medical Center
Coronary Heart Disease
CTCA Prior to Invasive Angiography in Post-Bypass Patients (BYPASS CTCA 2)
The goal of this clinical trial is to evaluate whether a coronary computed tomography angiography (CTCA)-guided strategy can reduce the risk of death, heart attack, stroke, and hospital admissions in patients experiencing angina…
- Trial name
- NCT07165678
- Testing
- CTCA
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Queen Mary University of London
Nicorandil
Oral Nicorandil in ST Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
To study the effects of early oral administration of nicorandil in the setting of PPCI among STEMI patients on early angiographic, electrocardiographic, echocardiographic and hard clinical outcomes.
- Trial name
- NCT04632121
- Testing
- Nicorandil 20 MG
- Volunteers
- 300 people
- Sponsor
- Ahmed Abdel Nasser Abdel Rady
Calcific Coronary Arteriosclerosis
Prospective Registry on Intravascular Lithotripsy
multicenter, international, all-comers registry aims to provide insights in the current application of IVL technology in patients with calcified coronary lesions undergoing PCI using IVL technology.
- Trial name
- BENELUX-IVL (NCT06577038)
- Testing
- PCI with use of IVL
- Where
- 8 sites in Belgium, Greece and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Leiden University Medical Center
Acute Coronary Syndrome
Impact of Traditional Chinese Medicine on the Gut Microbiota-dependent Trimethylamine N-oxide
Recent studies highlight the participation of gut microbes in the pathogenesis of both atherosclerotic heart disease and its adverse thrombotic events.
- Trial name
- TCM-TMAO (NCT03186625)
- Testing
- Compound Panax Notoginseng Granule
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
AKI - Acute Kidney Injury
Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients
Contrast-associated acute kidney injury (CA-AKI) is a common complication of procedures with intravascular contrast. Generally, CA-AKI is defined as serum creatinine (Scr) ≥ 25 to 50% or Scr rise around 0.3 to 0.5 mg/dl.
- Trial name
- NCT05540184
- Testing
- Trimetazidine 35 mg, Allopurinol 300 MG, Normal saline
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Percutaneous Coronary Intervention
Randomized Controlled Trials of Electro-acupuncture Effects on Perioperative Anxiety in Patients Treated With PCI
Randomized Controlled Trials of Electro-acupuncture Effects on Perioperative Anxiety in Patients Treated with PCI
- Trial name
- NCT03789344
- Testing
- acupuncture, Psychotherapy, blank control
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Huan Wang, MD
Platelet Aggregation Inhibitors, Dual Anti-Platelet Therapy
Ticagrelor in Elderly Patients Undergoing Percutaneous Coronary Intervention
The study is an investigator-sponsored, retrospective cohort study designed to compare efficacy and safety of ticagrelor in elderly patients undergoing percutaneous coronary intervention.
- Conditions
- Platelet Aggregation Inhibitors, Dual Anti-Platelet Therapy, Aged, Percutaneous Coronary Intervention
- Trial name
- NCT04999293
- Testing
- Ticagrelor
- Where
- China
- Volunteers
- 1,505 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Atrial Fibrillation, Percutaneous Coronary Intervention
A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention
The primary purpose of this study is to evaluate the safety for 2 different rivaroxaban treatment strategies and one Vitamin K Antagonist (VKA) treatment strategy utilizing various combinations of dual antiplatelet therapy (DAPT)…
- Trial name
- PIONEER AF-PCI (NCT01830543)
- Testing
- rivaroxaban 2.5 mg, rivaroxaban 15 mg, rivaroxaban 10 mg
- Where
- 348 sites in United States, Argentina and 23 more
- Volunteers
- 2,124 people
- Sponsor
- Janssen Scientific Affairs, LLC
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Coronary Artery Disease
The Stent or Surgery (SoS) Trial
This study compared two different methods of restoring blood flow to the heart when there has been a narrowing or blockage in the blood vessels that supply the heart.
- Trial name
- NCT00475449
- Testing
- percutaneous coronary intervention, coronary artery bypass grafting
- Volunteers
- 988 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust