Clinical trials: Perforated Bowel
Intra Abdominal Infections
Soluble Immune Checkpoints in Intra-Abdominal Infections
Intraabdominal infections is a life-threatening syndrome with a high incidence and a significant economic burden. The early-stage cytokine storm and the late-stage immunosuppression contribute to the mortality of sepsis.
- Trial name
- NCT07689266
- Testing
- Soluble Immune checkpoint levels
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Perforated Appendicitis
Study on Laparoscopic Operation for Perforated Appendicitis
The purpose of this study is to conduct a prospective observational study for the open approach and laparoscopic approach for perforated appendicitis.
- Trial name
- NCT00677989
- Testing
- Laparoscopic appendectomy, Open appendectomy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Acute Appendicitis, Perforated Gastroduodenal Ulcer
Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures
Aim of prospective randomized a placebo controlled study is to prove that in case of acute surgical procedure due to appendicitis, ileus of small bowel and perforation of small bowel and stomach appropriately administered…
- Conditions
- Acute Appendicitis, Perforated Gastroduodenal Ulcer, Small Bowel Obstruction
- Trial name
- NCT01524081
- Testing
- Metronidazole, Cefuroxime, Amoxicillin (+ clavulanic acid) and Fluconazole
- Where
- Czechia
- Volunteers
- 187 people
- Sponsor
- The Faculty Hospital Na Bulovce
Intestinal Perforation
Effect of Early Hydrocortisone on Risk of Gastrointestinal Perforations in Extremely Preterm Infants
A large, randomised control trial, the PREMILOC trial, has established that giving low dose hydrocortisone prophylactically in the first ten days of life reduces the risk of bronchopulmonary dysplasia in babies born before 32…
- Trial name
- NCT06515405
- Testing
- Hydrocortisone
- Where
- United Kingdom
- Volunteers
- 16,000 people
- Sponsor
- Imperial College London
Intestinal Perforation, Intestinal Obstruction
Direct Peritoneal Resuscitation for Intra-abdominal Catastrophes
It is a retrospective study. Patients, who presented with either traumatic or general surgery emergencies, undergone exploratory laparotomy, had an open abdomen management and received Direct Peritoneal Resuscitation in addition…
- Conditions
- Intestinal Perforation, Intestinal Obstruction, Trauma Abdomen
- Trial name
- NCT05208489
- Testing
- there is no intervention involved in this study
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- New York Medical College
Newborn Infants With Enterostomy by Congenital Malformations of the Gastrointestinal Tract, Necrotizing Enterocolitis and Spontaneous Intestinal Perforation
Intestinal Colonization in Newborn Infants With Enterostomy
The human microbiota, a collection of microorganisms mostly settled in the gastrointestinal tract, plays a major role in the maintenance of the hosts' health and in development of disease as well.
- Trial name
- NCT03340259
- Testing
- Exposure(s) of interest: enterostomy
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Universidade do Porto
Harm Reduction, Perforation During Colonoscopy
Fast Track Module Based Colonoscopy Training Programme for Surgical Trainees at North Jutland Surgical Departments
Specially educated trainers will be responsible for colonoscopy training of junior doctors. The educated trainers will have attended seminars held by Valori et al.
- Conditions
- Harm Reduction, Perforation During Colonoscopy, Colorectal Cancer
- Trial name
- NCT02425657
- Testing
- Training of junior doctors
- Where
- 3 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- Aalborg University Hospital
Perforated Appendicitis
Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis
The objective of this study is to scientifically evaluate two different management strategies for perforated appendicitis. The hypothesis is that early discharge with oral antibiotic therapy may result in a dramatic decrease in…
- Trial name
- NCT00462020
- Testing
- 5 days of IV antibiotics (ceftriaxone and metronidazole), Home with oral antibiotics when eating (ampicillin/clavulanic acid)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Children's Mercy Hospital Kansas City
Bowel Perforated, Bowel Obstruction
Effect of Implementation of the Danish Emergency Surgery (DANAKIR) Support Network on Post-discharge Outcomes After Major Emergency Abdominal Surgery
Effect of implementation of the Danish Emergency Surgery (DANAKIR) support Network on post-discharge outcomes after major emergency abdominal surgery: a prospective before and-after study Background Major emergency abdominal…
- Trial name
- DANAKIR (NCT05442164)
- Testing
- DANAKIR support network
- Volunteers
- 400 people
- Sponsor
- Herlev Hospital
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Intestinal Obstruction, Intestinal Perforation
Pathophysiology of Perioperative Fluid Management in Emergency Laparotomy
Pathophysiology of perioperative fluid management in patients undergoing emergency laparotomy.
- Conditions
- Intestinal Obstruction, Intestinal Perforation, Anastomotic Leak, Fluid Overload
- Trial name
- NCT03997721
- Where
- Denmark
- Volunteers
- 73 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Perforated Viscus, Intestinal Obstruction
Acute High-risk Abdominal Surgery Study - an Optimized Perioperative Course
The objective of this study is to implement an optimized perioperative course for patients undergoing acute high-risk abdominal surgery in order to improve the outcome.
- Trial name
- AHA (NCT01899885)
- Testing
- AHA (Acute Highrisk Abdominalsurgery): Optimized Course
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- Hvidovre University Hospital
Peptic Ulcer Perforations
Omitting Drains After Repair of Peptic Ulcer Perforations
. This study aimed to evaluate ERAS application outcomes via omitting the intraabdominal drains compared to regular using of the drains in patients undergoing perforated duodenal ulcer repairs in emergency abdominal surgeries.
- Trial name
- NCT06084741
- Testing
- Omitting of usage of intraabdominal drains after repair of peptic ulcer perforations, Using intraabdominal drains
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Peptic Ulcers
Risk Factors Affecting Mortality in Perforated Peptic Ulcer
Perforation is one of the most severe and life-threatening complications of peptic ulcer disease. This study aims to evaluate the risk factors associated with postoperative morbidity and mortality in patients undergoing surgery…
- Trial name
- NCT07050199
- Testing
- Emergency laparotomy
- Where
- Nepal
- Volunteers
- 85 people
- Sponsor
- Maharajgunj Medical Campus
Bowel Perforation, Abscess
Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis
Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction In previous…
- Conditions
- Bowel Perforation, Abscess, Leakage, Peritonitis
- Trial name
- NCT01784458
- Volunteers
- 46 people
- Sponsor
- University of Ulsan
Prematurity, Intestine Perforation
Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies
Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are common devastating gastrointestinal diseases in premature infants.
- Conditions
- Prematurity, Intestine Perforation, Necrotizing Enterocolitis (NEC), Short Bowel Syndrome (SBS)
- Trial name
- EMLFO-2 (NCT01674478)
- Testing
- Microlipid with fish oil, Microlipid
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Wake Forest University
Necrotizing Enterocolitis, Intestinal Perforation
Necrotizing Enterocolitis and Bowel Perforation in Very Preterm Infants - Long-term Follow up
Necrotizing enterocolitis (NEC) is a gastrointestinal syndrome characterized by transmural inflammation and necrosis of the large and/or small bowel and subsequent intramural gas-forming organisms into the intestinal wall.
- Conditions
- Necrotizing Enterocolitis, Intestinal Perforation, Premature Infant Disease
- Trial name
- NOR-NEC (NCT06757582)
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- University Hospital of North Norway
Perforated Appendicitis
Evaluation the Role of Laparoscopic Management of Perforated Appendicitis
A laparoscopic appendectomy (LA) was first reported by Semm in 1983. Since then, its advantages, such as the aesthetic appearance of the wound, less postoperative pain, and faster recovery which facilitates early discharge, have…
- Trial name
- NCT03267082
- Testing
- Laparoscopic management of perforated appendicitis
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Peritonitis, Anastomotic Leakage
Delayed Small-Bowel Anastomosis in Patients With Postoperative Peritonitis
Surgical management results for 114 patients with postoperative peritonitis due to small-bowel perforations, necrosis, and anastomotic leakage were comparatively analyzed.
- Conditions
- Postoperative Peritonitis, Anastomotic Leakage, Intestinal Perforation Small
- Trial name
- Peritonitis (NCT03690687)
- Testing
- Primary anastomosis, Delayed anastomosis, Enterostomy
- Volunteers
- 114 people
- Sponsor
- Andrey Nikolayevich Zharikov
Perforated Appendicitis
Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis
The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated…
- Trial name
- PA protocol (NCT04039750)
- Testing
- antibiotic rinse with suction, suction only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Prisma Health-Upstate