Clinical trials: Perforated Bowel
Perforated Peptic Ulcer
Falciformopexy for Treatment Perforated Peptic Ulcer.
Use the falciform ligament flap for the treatment of perforated peptic ulcer
- Trial name
- NCT05715450
- Testing
- Falciformopexy for Treatment Perforated Peptic Ulcer
- Volunteers
- 25 people
- Sponsor
- Assiut University
Intra-Abdominal Infections, Intestinal Obstruction
Capillary Leak Index as a Prognostic Indicator for Post-Operative Abdominal Sepsis in Critically Ill Patients
In this study the investigators going to evaluate the "CLI" as an early prognostic indicator for post-operative abdominal sepsis in critically ill patients.
- Conditions
- Intra-Abdominal Infections, Intestinal Obstruction, Appendicitis Acute, Perforated Viscus
- Trial name
- CLI (NCT06901544)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Intestinal Perforation, Necrotizing Enterocolitis
IRT in Infants With Intestinal Perforation
This study is designed to evaluate a novel tool to aid in the diagnosis of intestinal perforation in infants who are at high risk.
- Trial name
- NCT01530828
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Marginal Ulcer, Chronic Ulcer Disease
Chronic Marginal Ulcers After Gastric Bypass
The purpose of this study is to determine the feasibility, safety, and efficacy of revision gastroplasty along with other adjunct procedures in the treatment of intractable / chronic marginal ulcers after Roux-en-Y gastric…
- Conditions
- Marginal Ulcer, Chronic Ulcer Disease, Persistent Ulcer Disease, Recurrent Ulcer Disease
- Trial name
- ChronicMU (NCT01041079)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Perforated Appendicitis
APPI-Cost Trial for Perforated Appendicitis
The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI…
- Trial name
- NCT06705842
- Testing
- PVI, Usual Care
- Where
- United States
- Volunteers
- 346 people
- Sponsor
- The University of Texas Health Science Center, Houston
Perforated Appendicitis
Effect of Intraperitoneal Drain Placement on Postoperative Outcomes Following Laparoscopic Appendectomy in Adult Patients With Perforated Appendicitis
Acute appendicitis is the most common acute abdomen, and a small number of patients can progress to perforated appendicitis, which has significantly higher complications than non-perforated appendicitis.
- Trial name
- LADPA (NCT06927765)
- Testing
- No abdominal drain is placed
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Appendicitis, Cholecystitis
Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection
This is a phase 3b/4 randomized, open-label, comparative, multicenter study of the safety and efficacy of tigecycline to ceftriaxone sodium plus metronidazole in hospitalized subjects with cIAI (Complicated Intra-Abdominal…
- Conditions
- Appendicitis, Cholecystitis, Cross Infection, Diverticulitis
- Trial name
- NCT00195351
- Testing
- tigecycline, ceftriaxone sodium + metronidazole
- Where
- 66 sites in United States, Argentina and 4 more
- Volunteers
- 467 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Perforated Appendicitis
Perforated Appendicitis and Postoperative Antibiotics Pilot Trial
The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix.
- Trial name
- PAPA Pilot (NCT07656636)
- Testing
- Postoperative antibiotico-prophylaxis, No postoperative antibiotics
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Perforated Appendicitis, Postoperative Infection
Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis
After appendix has been removed for perforated appendicitis, patients will receive postoperative antibiotics. In the last 5 years, the literature has transitioned from a 3 -drug therapy to 2-drug therapy.
- Trial name
- NCT03289351
- Testing
- Piperacillin, Tazobactam Drug Combination
- Where
- 2 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Phoenix Children's Hospital
Liver Transplantation, Intestinal Perforation
Intestinal Perforation in Patients Receiving an Orthtopic Liver Transplantation in the Montpellier University Hospital
Liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. However some patients develop intestinal perforations for which the prognosis is poor.
- Conditions
- Liver Transplantation, Intestinal Perforation, Digestive System Fistula, Intestinal Fistula
- Trial name
- Perfogreffe (NCT04180735)
- Testing
- Liver transplantation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Intestinal Atresia, Necrotizing Enterocolitis
The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery.
Background: Intestinal resections are commonly performed in the pediatric population. Perfusion of the bowel is one of the most important factors determining the viability of an intestinal anastomosis.
- Conditions
- Intestinal Atresia, Necrotizing Enterocolitis, Hirschsprung Disease, Gastroschisis
- Trial name
- NCT04020939
- Testing
- SPY imaging, Indocyanine Green
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Acute, Perforated Appendicitis
Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study
The purpose of this study is to determine the effect of intra-abdominal irrigation with povidone-iodine (PVI) versus usual care on the rate of 30-day postoperative intra-abdominal abscesses (IAA) and to determine the effect of…
- Trial name
- PAPPA (NCT04200729)
- Testing
- Irrigation with PVI, Usual care
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- The University of Texas Health Science Center, Houston
Short Bowel Syndrome, Necrotizing Enterocolitis
Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy
Necrotizing enterocolitis (NEC) and intestinal perforation are common in premature infants. Often surgery is needed to remove the dead bowel and create an ostomy (a temporary intestinal opening on the infant's abdomen).
- Conditions
- Short Bowel Syndrome, Necrotizing Enterocolitis, Small Intestine Perforation
- Trial name
- EMLFO (NCT01306838)
- Testing
- MicroLipid and fish oil, Routine care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University
Perforated Appendicitis
Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis
The purpose of this study is to compare traditional triple antibiotic therapy against dual single day dosing antibiotic therapy in the management of perforated appendicitis in children.
- Trial name
- NCT00195923
- Testing
- Ampicillin, gentamicin, clindamycin, flagyl, ceftazidime
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Mercy Hospital Kansas City
Diverticulitis, Surgical Site Infection
Surgical Site Infection Outcomes in Natural Orifice Intracorporeal Anastomosis and Extraction (NICE) Procedure - The NICE Trial
The goal of this observational study is to learn if a new surgical technique, called the NICE procedure, is as safe as standard methods for treating benign left-sided colon and rectal diseases in adults.
- Conditions
- Diverticulitis, Surgical Site Infection, Surgical Site Infections, Colorectal Surgery
- Trial name
- NCT06957236
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Methodist Hospital Research Institute
Gastrointestinal Fistula, Gastrointestinal Perforation
Endoscopic Treatment of Intestinal Fistulas and Perforations
Gastrointestinal leaks or perforations are currently treated through either open or laparoscopic surgical procedures. The purpose of this research is to determine whether new endoscopic tools are safe and effective in the…
- Trial name
- NCT01303653
- Testing
- endoscopic closure of gastrointestinal fistulas and perforations
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Oregon Clinic
Intestinal Anastomotic Leak, Intestinal Perforations
Endosponge Vacuum Therapy (E-VAC) Registry of Intestinal Anastomotic Leaks and Perforations
The purpose of this registry is to collect data on the clinical use of endoluminal vacuum (E-Vac) therapy to treat both upper and lower intestinal leaks and perforations.
- Trial name
- NCT02477930
- Testing
- No interventions are done
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor Research Institute
Small Bowel Perforations
Retrospective Analysis on Small Bowel Perforations
A retrospective, monocentric, code-related data analysis of patients with small bowel perforations was performed for the period 2010 to 2019.
- Trial name
- SBP (NCT05471999)
- Testing
- surgery
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- University Hospital Tuebingen
Perforated Peptic Ulcer
Open Versus Laparoscopic Repair of Perforated Peptic Ulcer
The aim of this clinical trial is to compare the outcomes of open versus laparoscopic repair for perforated peptic ulcer and provide evidence-based guidance to the selection of the most appropriate operative technique at Sohag…
- Trial name
- NCT06484699
- Testing
- open repair of perforated peptic ulcer, laparoscopic repair of perforated peptic ulcer
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Appendicitis With Perforation, Appendectomy
Effect of Probiotic's Consumption on Several Markers in Perforated Appendix Patients With Diffuse Peritonitis
Does the administration of the probiotic Lactobacillus plantarum sp. have an impact on reducing leukocyte levels, segmented neutrophil counts, postoperative pain, and length of hospitalization in patients with diffuse peritonitis…
- Conditions
- Appendicitis With Perforation, Appendectomy, Probiotic
- Trial name
- NCT06856434
- Testing
- Lactobacillus plantarum sp Probiotic
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Padjadjaran