Clinical trials: Perforated Bowel
Appendicitis Perforated, Appendectomy, Laparoscopic
Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis
The ALPACA-MC trial is a blinded, multicentre randomized controlled trial comparing two postoperative antibiotic treatments for children undergoing laparoscopic appendectomy for perforated appendicitis.
- Conditions
- Appendicitis Perforated, Appendectomy, Laparoscopic, Antibiotic, Pediatric
- Trial name
- ALPACA-MC (NCT07869095)
- Testing
- Piperacillin/Tazobactam, Ceftriaxone + Metronidazole
- Volunteers
- 180 people
- Sponsor
- McMaster Children's Hospital
Complicated Appendicitis, Perforated Appendicitis
Antibiotic Duration in Post-appendectomy Abscess
This is a randomized study of patients 2-17 years old who are diagnosed with perforated appendicitis and develop an abscess after laparoscopy that is subsequently drained.
- Trial name
- NCT03795194
- Testing
- ampicillin/clavulanate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Phoenix Children's Hospital
Diverticulitis, Diverticulitis Colon
Management and Evolution of Acute Diverticulitis With Pericolic Free Gas
The severity of diverticulitis is usually graded with the use of modified Hinchey Criteria. However, there is a condition often seen in the CT scan that is not included in this classification itself; 1-2 pericolic bubbles but no…
- Conditions
- Diverticulitis, Diverticulitis Colon, Diverticulitis; Perforation, Bowel, Diverticulitis of Sigmoid
- Trial name
- ADiFas (NCT04311385)
- Testing
- CT imaging
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Peptic Ulcer Perforation
Peptic Ulcer Perforation Study
The objective of this study is to implement an optimized perioperative course for patients surgically treated for peptic ulcer perforation in order to improve the outcome for these patients.
- Trial name
- PULP (NCT00624169)
- Testing
- An optimized perioperative course
- Where
- 7 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital at Herlev
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Typhoid Fever, Intestinal Perforation
TyVECO: Surveillance Protocol
In Kisantu Health Zone, approximate population 200,000, fever surveillance will be implemented in 8 health centers and 1 tertiary hospital.
- Trial name
- TyVECO (NCT05562102)
- Testing
- Typbar-TCV, Bharat Biotech
- Where
- 9 sites in Democratic Republic of the Congo
- Volunteers
- 48,000 people
- Sponsor
- International Vaccine Institute
Appendicitis Acute, Appendicitis Perforated
Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis
The exploratory objective of this pilot study is to evaluate the feasibility and safety of an enhanced recovery protocol that will allow adult patients to be discharged to home on an oral antibiotic regimen for three days…
- Conditions
- Appendicitis Acute, Appendicitis Perforated, Appendicitis With Perforation, Appendicitis Suppurative
- Trial name
- NCT06948071
- Testing
- Discharge on oral antibiotics
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Advanced Colorectal Cancer in Elderly Patient
The Management of Complicated Colo-rectal Cancer in Older Patients in the Emergency Setting: the CO-OLDER Study
This is a multicenter observational study aimed to investigate the management of older patients aged 75 years old and over admitted to the emergency department with complicated colorectal cancer.
- Trial name
- CO-OLDER (NCT05788224)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poissy-Saint Germain Hospital
Perforated Appendicitis
Diagnostic Value of Hyperbilirubinaemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis
The values of laboratory examinations which are useful for the diagnoses of appendicitis are white blood cell count (WBC), C-reactive protein (CRP) and erythrocyte blood sedimentation rate (ESR).
- Trial name
- NCT00677417
- Volunteers
- 538 people
- Sponsor
- Ruhr University of Bochum
Ulcer Disease After Gastric Bypass, Marginal Ulcer
Perforated Marginal Ulcer After Gastric Bypass
A common late complication after gastric bypass surgery is marginal ulceration that is defined as ulcers at the margins of the gastrojejunostomy, mostly on the jejunal side.
- Conditions
- Ulcer Disease After Gastric Bypass, Marginal Ulcer, Perforated Marginal Ulcer, Acutely Perforated Marginal Ulcer
- Trial name
- PerforatedMU (NCT01041196)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Perforated Appendicitis
Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
To compare the effect of a single-agent home intravenous (IV) versus oral antibiotic therapy on complication rates and resource utilization following appendectomy for perforated appendicitis
- Trial name
- NCT02724410
- Testing
- home intravenous ertapenem, home oral amoxicillin-clavulanate, peripheral inserted central Catheter
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
Appendicitis, Appendicitis; Perforation
Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis
To determine the effectiveness of the use of probiotics in patients with a diagnosis of complicated appendicitis on antibiotic associated diarrhea (AAD).
- Trial name
- NCT04529980
- Testing
- Lactobacillus rhamnosus GG (LGG) Probiotic
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Children's Health
Perforated Appendicitis
Irrigation Versus No Irrigation for Perforated Appendicitis
The purpose is to quantify the effect of irrigation during laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT00854815
- Testing
- Irrigation, No Irrigation
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Children's Mercy Hospital Kansas City
Enterocolitis, Necrotizing, Atresia; Bowel
Timing of Stoma Closure in Neonates
Some babies require emergency surgery on their tummy in the first few months of life. This is most commonly because they were born prematurely and developed a bowel problem (called NEC) or a blockage of the bowel.
- Conditions
- Enterocolitis, Necrotizing, Atresia; Bowel, Gastroschisis, Meconium Ileus
- Trial name
- ToSCiN (NCT04713579)
- Testing
- No intervention - observational study
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Manchester University NHS Foundation Trust
Infant, Newborn, Infant, Low Birth Weight
Observational Study of Surgical Treatment of Necrotizing Enterocolotis
The purposes of this study were: 1) to compare mortality and postoperative morbidities in extremely low birth weight (ELBW) infants who underwent initial laparotomy or drainage for necrotizing enterocolitis (NEC) or isolated…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- NEC Surgery (NCT01223261)
- Where
- 17 sites in United States
- Volunteers
- 156 people
- Sponsor
- NICHD Neonatal Research Network
Perforated Peptic Ulcer
Management of Perforated Peptic Ulcer
Perforated peptic ulcer (PPU) is a common surgical emergency. Exploratory laparotomy and repair with the omental patch are routine surgical intervention till now.
- Trial name
- NCT05699616
- Testing
- Repair of perforated peptic ulcer
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- South Valley University
Infant, Newborn, Infant, Low Birth Weight
Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis
This study will compare the effectiveness of two surgical procedures -laparotomy versus drainage - commonly used to treat necrotizing enterocolitis (NEC) or isolated intestinal perforations (IP) in extremely low birth weight…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- NEST (NCT01029353)
- Testing
- Laparotomy, Drainage
- Where
- 22 sites in United States
- Volunteers
- 529 people
- Sponsor
- NICHD Neonatal Research Network
Perforated Peptic Ulcer
The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction
This is a multicenter trial comparing laparoscopic correction of a perforated peptic ulcer with the open technique by upper laparotomy.
- Trial name
- LAMA (NCT00745667)
- Testing
- laparoscopic surgery, Upper laparotomy
- Where
- Netherlands
- Volunteers
- 109 people
- Sponsor
- Erasme University Hospital
Ileus, Ogilvie Syndrome
Therapeutic Oxygen for Gastrointestinal Atony (TOGA)
This study is a non invasive study to see if 100% oxygen therapy will help to resolve an intestinal obstruction.
- Conditions
- Ileus, Ogilvie Syndrome, Small Bowel Obstruction
- Trial name
- TOGA (NCT03386136)
- Testing
- 100% Oxygen
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Florida
Peptic Ulcer Perforation
Morbidity After Surgical Treatment of Perforated Ulcer
The main objective of our study is to identify the risk factors for postoperative morbidity after surgical treatment of Perforated peptic ulcer
- Trial name
- NCT05489497
- Testing
- Primary closure with or without omental grafting
- Volunteers
- 116 people
- Sponsor
- University of Monastir