Clinical trials: Perfusion
Cystic Fibrosis
Non-contrast Lung Perfusion Mapping Applied for New Insights in Cystic Fibrosis
Cystic fibrosis (CF) results in the thickening of mucus in the lungs and other organs due to dysfunction of a transmembrane conductance protein.
- Trial name
- NCT04467957
- Testing
- Initiation of CFTR Modulator, Hyperpolarized Xenon 129
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke
Prognosis in Subacute Ischemic Stroke Using Multimodal Imaging
We enrolled patients with subacute IS, associated with moderate-to-severe stenosis of the unilateral cervical internal carotid artery, who underwent 4D ASL.
- Trial name
- NCT06289036
- Where
- China
- Volunteers
- 28 people
- Sponsor
- The First Hospital of Hebei Medical University
Free Flap Evaluation, Indocyanine Green Concentration
Diluted Indocyanine Green Angiography: a Novel Approach to Free Flap Perfusion Evaluation in Reconstructive Microsurgery
The evaluation of perfusion in free flaps is crucial in clinical practice. Currently, the gold standard for evaluation is subjective through clinical assessment.
- Conditions
- Free Flap Evaluation, Indocyanine Green Concentration, Perfusion
- Trial name
- NCT06220357
- Testing
- Indocyanine Green
- Where
- Indonesia
- Volunteers
- 47 people
- Sponsor
- Universitas Indonesia
Cognitively Normal Older Adults, Hypertension
Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)
The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Alzheimer's Disease pathology (i.e., excessive brain amyloid and tau…
- Conditions
- Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Dementia
- Trial name
- IPAT (NCT05331144)
- Testing
- Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine), PCP
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Rong Zhang
Glioblastoma
Multicentre Validation of How Vascular Biomarkers From Tumor Can Predict the Survival of the Patient With Glioblastoma
Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The relationship between non-invasive Magnetic Resonance Imaging (MRI) biomarkers at preoperative, postradiotherapy…
- Trial name
- ONCOhabitats (NCT03439332)
- Where
- Spain
- Volunteers
- 305 people
- Sponsor
- Juan M Garcia-Gomez
Diagnostic Imaging, Myocardial Ischemia
Sonazoid in Myocardial Perfusion Imaging
Currently, Sonazoid is mainly used for imaging liver lesions by assessing perfusion characteristics. However, the ultrasound technology is the same as for cardiac imaging and the stability of the microbubbles will potentially aid…
- Trial name
- (SIMPI) (NCT05637333)
- Testing
- Contrast Stress Echocardiography
- Where
- United Kingdom
- Sponsor
- London North West Healthcare NHS Trust
Pregnancy
Placental Transfer of Sugammadex in the Human Placental Perfusion Model
Preclinical research raised concern regarding the foetal effects of using sugammadex during pregnancy. However, to the best of our knowledge, the placental transfer of sugammadex has never been measured.
- Trial name
- NCT06634355
- Testing
- Sugammadex
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Congenital Heart Defects, Hypoplastic Left Heart Syndrome
Cerebral Perfusion During Neonatal Cardiac Surgery
Neonates with a congenital heart defect are often in need of early cardiac surgery. In complex congenital heart defects, cardiopulmonary bypass is usually employed, with or without deep hypothermic circulatory arrest (DHCA).
- Conditions
- Congenital Heart Defects, Hypoplastic Left Heart Syndrome, Aortic Coarctation
- Trial name
- NCT01032876
- Testing
- Deep Hypothermic Circulatory Arrest, Antegrade Cerebral Perfusion
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- UMC Utrecht
Colo-rectal Surgery, Anastomotic Leak Large Intestine
Comparison of Rates of Anastomotic Leak in Patients Undergoing Colo-rectal Surgery When Bowel Perfusion and Resection Margin is Deterimined by Intra-operative Infra-red Thermography or by Conventional Method
Pilot RCT with 20 patients in both test and control group. In the control group resection \& anastomosis was done using the conventional method.
- Conditions
- Colo-rectal Surgery, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum
- Trial name
- NCT06180564
- Testing
- Intra-operative Infra-red thermography
- Where
- India
- Volunteers
- 43 people
- Sponsor
- Sir Ganga Ram Hospital
Coronary Artery Disease
Gadobutrol / Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)
Subjects being evaluated for suspected or known Coronary artery Disease (CAD) based on signs and/or symptoms, will be invited to participate in the study.
- Trial name
- GadaCAD 2 (NCT01890434)
- Testing
- Gadobutrol (Gadavist, Gadovist, BAY86-4875)
- Where
- 24 sites in United States, Australia and 2 more
- Volunteers
- 478 people
- Sponsor
- Bayer
Modulation of Cardiovascular Parameters and Sympathovagal Balance in Healthy Subjects
Pilot Study - Auricular Vagus Nerve Stimulation Effects on Cardiovascular Parameters
The purpose of this pilot study is to evaluate the effect of auricular autonomous nervous system stimulation on cardiovascular parameters and sympathovagal balance in healthy subjects.
- Trial name
- NCT02139293
- Testing
- PrimeStim
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Perfusion Imaging, MRI
MRI Perfusion Imaging at 3Tx Compared to Invasive FFR Measurements
Coronary artery disease (CAD) has a great significance concerning prevalence and mortality in the western world. It is usually diagnosed by catheterization and coronary arteries are visually assessed by the examiner.
- Conditions
- Perfusion Imaging, MRI, Myocardial Fractional Flow Reserve, Myocardial Ischemia
- Trial name
- Vision MRT (NCT01277055)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Heart Center Bogenhausen
Liver Transplant Surgery, Liver Transplantation
Open Label Trial of Deceased Donor Livers Transplanted After DHOPE With eXVIVO LIVER Perfusion
The purpose of this clinical study is to confirm the safety and effectiveness of dual hypothermic oxygenated perfusion (DHOPE) using the Liver Assist to preserve deceased donor livers for transplantation.
- Trial name
- NCT06916325
- Testing
- dual hypothermic oxygenated perfusion (DHOPE)
- Volunteers
- 215 people
- Sponsor
- XVIVO Perfusion
Heart Failure, Systolic, Heart Failure, Diastolic
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle.
- Conditions
- Heart Failure, Systolic, Heart Failure, Diastolic, Peripheral Arterial Disease, Overweight and Obesity
- Trial name
- NCT06009276
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia
Healthy Volunteer, Coronary Arterial Disease
Ultralow Dose PET Imaging of 18F-flurpiridaz
The goal of this clinical trial is to evaluate an investigational ultralow dose positron emission tomography (PET) imaging technique for known or suspected coronary artery disease (for detecting myocardial ischemia or infarction)…
- Conditions
- Healthy Volunteer, Coronary Arterial Disease, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT07284576
- Testing
- 18F-flurpiridaz
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Fetal Conditions, Maternal; Procedure
A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures
In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery.
- Conditions
- Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome
- Trial name
- NCT06056635
- Testing
- Karl Storz Curved Scope, Karl Storz Straight Scope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Coronary Artery Disease
Filgrastim for the Promotion of Collateral Growth in Patients With CAD
The purpose of this study in humans with stable coronary artery disease (CAD) treatable by PCI (percutaneous coronary intervention) is to evaluate the safety and efficacy of subcutaneous delivery of recombinant granulocyte colony…
- Trial name
- NCT00596479
- Testing
- Filgrastim (rG-CSF)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
Stress CT Perfusion in Patients With Chest Pain
Our hypothesis is that quantitative 3D analysis of cardiac CT images obtained during vasodilator stress can accurately identify patients presenting at the emergency department with acute chest pain due to underlying…
- Trial name
- NCT01969916
- Testing
- Regadenoson
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
Lung Diseases, Pulmonary Embolism
Magnetic Resonance Diagnosis of Pulmonary Embolism
The purpose of this study is to evaluate the diagnostic accuracy of thoracic magnetic resonance imaging with gadolinium-enhanced, unenhanced and perfusion sequences in patients with clinically suspected acute pulmonary embolism…
- Trial name
- IRM-EP (NCT01077778)
- Testing
- Gadolinium-enhanced Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
End Stage Liver DIsease
Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation.
Study groups: The study is a multicenter (Pisa and Milan), prospective, randomized study comparing D-HOPE (HMP) vs NMP in DCD and ECD-DBD (extended criteria brain-dead donors).
- Trial name
- DCDNet (NCT04744389)
- Testing
- Hypothermic Machine Perfusion, Normothermic Machine Perfusion
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
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