Clinical trials: Perfusion Pressures
Traumatic Brain Injury, Severe Traumatic Brain Injury
Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II
After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure
- Trial name
- Cogitate II (NCT07287358)
- Testing
- Optimal cerebral perfusion pressure
- Where
- 4 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- Maastricht University Medical Center
Traumatic Brain Injury, Pediatric
Age Related Thresholds for Management of Severe Head Injury in Paediatrics: An Extension of STARSHIP
Traumatic brain injury in children can cause serious and long-lasting neuro-disability. However, there is still limited evidence about the best ways to treat children with severe brain injury in intensive care.
- Conditions
- Traumatic Brain Injury, Pediatric, Cerebral Perfusion Pressure, Cerebral Autoregulation
- Trial name
- ARTSHIP (NCT07834476)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Spinal Cord Injuries (SCI), Blood Pressure
AI-Guided Predictions of Blood Pressure Dysregulation Using Perfusion Index as a Novel Biomarker in Persons With Spinal Cord Injury
The goal of this clinical trial is to determine if perfusion index (PI) can reliably predict changes in systolic blood pressure (SBP) in persons with spinal cord injury (SCI) during a cool temperature challenge.
- Conditions
- Spinal Cord Injuries (SCI), Blood Pressure, Thermoregulation, Perfusion Index
- Trial name
- NCT07699094
- Testing
- Controlled Cool Thermal Challenge (18°C)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Intracranial Pressure, Circulation System
The Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in the Steep Trendelenburg Position During Robot-assisted Prostatectomy, and Its Effect on Postoperative Cognition
Patients scheduled for robot-assisted prostatectomy will be randomized to either high or low concentrations of carbon dioxide in the blood.
- Conditions
- Intracranial Pressure, Circulation System, Cerebral Perfusion Pressure, Cognitive Function
- Trial name
- TILTDOWN-3 (NCT06865027)
- Testing
- Ventilation strategy
- Where
- Norway
- Volunteers
- 46 people
- Sponsor
- University Hospital, Akershus
Cerebral Perfusion Pressure, Trendelenburg
Transcranial Doppler and NIRS Monitoring of Cerebral Hemodynamics in Pediatric Laparoscopic Surgery
Laparoscopic surgery has become increasingly common in pediatric patients due to its minimally invasive nature and favorable postoperative outcomes.
- Conditions
- Cerebral Perfusion Pressure, Trendelenburg, Pediatric
- Trial name
- NCT07482514
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hanife Kabukcu
Cerebral Perfusion Pressure, Trendelenburg
Evaluation of Cerebral Perfusion in Supine and Steep Trendelenburg Positions During Robotic Prostatectomy
Evaluation of Cerebral Perfusion in Supine and Steep Trendelenburg Positions During Robotic Prostatectomy Robotic endoscopic radical prostatectomy requires pneumoperitoneum and the steep Trendelenburg position to ensure optimal…
- Trial name
- NCT07317258
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hanife Kabukcu
Septic Shock, Fluid Resuscitation
Critical Closing Pressure and PCO₂ Gap in Fluid Resuscitation for Septic Shock
This study is based on the following key hypotheses: PvaCO₂ (Venous-to-Arterial CO₂ Gap) Hypothesis: Changes in PvaCO₂ (ΔPvaCO₂) following fluid resuscitation correlate with changes in cardiac output (CO) and can serve as a…
- Conditions
- Septic Shock, Fluid Resuscitation, Tissue Perfusion Pressure, Carbon Dioxide Pressure
- Trial name
- NCT07043192
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College
Comparison Between Perfusion Index and Pulse Pressure Variability for Prediction of Intravascular Volume During Major Abdominal Surgeries
Comparison Between Perfusion Index and Pulse Pressure Variability for Prediction of Intravascular Volume During Major Abdominal Surgeries
Each year, at least 310 million patients undergo major surgery worldwide, procedures that involve the administration of intravenous fluids Intraoperative hemodynamic management is challenging because precise assessment of the…
- Trial name
- NCT07024108
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Intracerebral Hemorrhage, Critically Ill
Early Multimodal Neuromonitoring For Spontaneous Intracerebral Hemorrhage (ICH)
The investigators intend to assess the predictive value of early (first 48 hours) multimodal neuromonitoring parameters concerning late survival in critically ill intracerebral hemorrhage (ICH) patients.
- Conditions
- Intracerebral Hemorrhage, Critically Ill, Intracranial Pressure, Cerebral Perfusion Pressure
- Trial name
- NCT05501613
- Testing
- Multimodal Neuromonitoring
- Where
- Portugal
- Volunteers
- 65 people
- Sponsor
- Universidade do Porto
Optimal Cerebral Perfusion Pressure on the Outcome of aSAH Patients
NIRS Directed Optimal Cerebral Perfusion Pressure on the Outcome of Aneurysmal Subarachnoid Hemorrhage Patients
Objectives: To investigate the impact of NIRS directed optimal cerebral perfusion pressure on the outcome of aSAH patients. Study design: A multicenter, single-blinded, randomized controlled trial.
- Trial name
- NCT05003232
- Testing
- Near-infrared spectroscopy (NIRS) and ICM+
- Volunteers
- 150 people
- Sponsor
- Xiangya Hospital of Central South University
Pressure Distribution, Military Litters
NATO Litter: Fluid Immersion System (FIS) Versus Traditional Mattress for Pressure Dispersion
The purpose of this study is to measure peak skin interface pressures and the total area of the body exposed to skin interface pressure above 30 mm Hg at different areas of the body in the supine position on two different support…
- Conditions
- Pressure Distribution, Military Litters, Peak Pressure Index, Total Surface Area
- Trial name
- NCT03483623
- Testing
- NATO WELP combination, NATO FIS combination, RAVEN WELP combination
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Increase in Intra-abdominal Pressure, Increase in Intracranial Pressure (ICP)
Changes in Cerebral Oxygenation Studies During Laparoscopy Procedure
The motivation results from the fact, that an intra-abdominal pressure is correlated with cerebral perfusion, in a mechanism of reducing venous outflow.
- Conditions
- Increase in Intra-abdominal Pressure, Increase in Intracranial Pressure (ICP), Laparoscopy, Cerebral Perfusion and Oxygenation
- Trial name
- NCT03640741
- Testing
- Laparoscopy
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences
Cerebral Perfusion Pressure, Vasopressor Agents
Physiologic Study of Cerebral Perfusion
The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients
- Conditions
- Cerebral Perfusion Pressure, Vasopressor Agents, Shock, Magnetic Resonance Imaging (MRI), Functional
- Trial name
- NCT02744625
- Testing
- Higher doses of vasopressor therapy for a MAP of 75 mmHg, Lower doses of vasopressor therapy for a MAP of 65 mmHg, Propofol for light sedation
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Cerebral Blood Flow, Cerebral Perfusion Pressure
Continous Assessment of Cerebral Autoregulation With Near-infrared Spectroscopy
Cerebral autoregulation can be explained by a tight coupling between oxygen supply and demand of the brain, and is essential to maintain a constant cerebral blood flow (CBF) in the context of changes in cerebral perfusion…
- Trial name
- NCT02959008
- Testing
- measure TOI and BP
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yu Liyun
Perfusion Pressures, Central Venous Pressure
Sternal Wall Pressure in the Cath Lab
This protocol is a prospective interventional pilot study at the Children's Hospital of Philadelphia to determine whether or not two increments of sternal pressure known to occur during "leaning" in CPR affects hemodynamic…
- Conditions
- Perfusion Pressures, Central Venous Pressure, Cardiac Output, CPR
- Trial name
- NCT01117883
- Testing
- Application of two different sternal weights
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia