Clinical trials: Periampullary Tumor
Pancreatic Cancer, Periampullary Cancer
Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas
This is a single-center, randomized controlled trial comparing the efficacy of pancreaticojejunostomy with modified N-butyl-2-cyanoacrylate(Glubran® 2) versus standard pancreaticojejunostomy without cyanoacrylate in preventing…
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Duodenal Cancer, Cholangiocarcinoma
- Trial name
- NBCA-MS (NCT07155525)
- Testing
- Pancreaticojejunostomy with Modified N-Butyl-2-Cyanoacrylate (Glubran® 2), Standard(duct-to-mucosa) Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Minia University
Biliary Stricture, Biliary Obstruction Due to Common Bile Duct Stone
SpyGlass AMEA Registry
The purpose of this study is to document indications for cholangioscopy and clinical utility of the SpyGlass Direct Visualization System (DVS) throughout the AMEA (Asia, Middle-East, Africa) region when used per standard of…
- Conditions
- Biliary Stricture, Biliary Obstruction Due to Common Bile Duct Stone, Periampullary Tumor, Hemobilia
- Trial name
- NCT02281019
- Testing
- ERCP (Endoscopic Retrograde Cholangiopancreatography), SpyGlass DVS and SpyGlass Digital Simple (DS)
- Where
- 20 sites in Australia, Hong Kong and 8 more
- Volunteers
- 526 people
- Sponsor
- Boston Scientific Corporation
Pancreatic Adenocarcinoma, Pancreatic Cysts
Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors
This multicenter randomized trial aims to primarily assess and compare the functional recovery of patients who undergo open versus robotic pancreaticoduodenectomy for benign and malignant lesions of the head of the pancreas.
- Conditions
- Pancreatic Adenocarcinoma, Pancreatic Cysts, Pancreatic Endocrine Tumors, Chronic Pancreatitis
- Trial name
- PORTAL (NCT04400357)
- Testing
- Robotic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Ruijin Hospital
Pancreas Cancer, Periampullary Cancer
Neoadjuvant vs Upfront Surgery for Resectable Pancreatic Cancer and Periampullary Cancer
Adjuvant chemotherapy after surgery significantly improved the survival of pancreatic cancer (PC) patients, but there is a problem that only about 50% of patients start adjuvant chemotherapy after pancreatectomy.
- Conditions
- Pancreas Cancer, Periampullary Cancer, Periampullary Carcinoma Resectable, Pancreatic Cancer Resectable
- Trial name
- NCT07081360
- Testing
- Neoadjuvant chemotherapy, Upfront Surgery Group
- Where
- Egypt
- Volunteers
- 262 people
- Sponsor
- Minia University
Periampullary Tumor
The Effect of ERAS on Pancreaticoduodenectomy
Enhanced Recovery After Surgery (ERAS) is not the program that aim to reduce postoperative hospital stay, but the multimodal strategies that aim to attenuate the loss of, and improve the restoration of,functional capacity after…
- Trial name
- ERAS (NCT02372331)
- Testing
- ERAS perioperative management
- Where
- South Korea
- Volunteers
- 276 people
- Sponsor
- Asan Medical Center
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
This randomized controlled trial investigates the safety and efficacy of injecting N-butyl-2- cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07230509)
- Testing
- Pancreatic parenchymal injection of N-butyl-2- cyanoacrylate(Histoacryl®)Injection Group., Standard Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Pancreatic Cancer, Periampullary Tumor
Double Bypass Versus Stent-treatment in Irresectable Pancreatic Cancer
Double bypass (hepaticojejunostomy + gastrojejunostomy) is compared to stent strategy in patients planned for curative pancreatic resection in whom peroperative findings makes resection impossible.
- Trial name
- NCT01569282
- Testing
- Hepaticojejunostomy and gastroenterostomy, Stent strategy
- Where
- 6 sites in Sweden
- Sponsor
- Göteborg University
Pancreatic Ductal Adenocarcinoma, Periampullary Cancer
Escitalopram to Placebo in Patients With Localized Pancreatic Cancer
Use of antidepressants for participants with localized pancreatic and periampullary cancer receiving neoadjuvant therapy.
- Trial name
- NCT05289830
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Fistula
Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy
Patients who are diagnosed with periampullary cancer will be performed pancreaticoduodenectomy with 3 types of pancreatic-jejunal anastomosis reconstructions.
- Trial name
- NCT05017207
- Testing
- Pancreaticoduodenectomy
- Where
- Vietnam
- Volunteers
- 183 people
- Sponsor
- Vo Truong Quoc
Pancreatic Cancer, Periampullary Adenocarcinoma
Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma
The investigators are looking to see if a certain dose of stereotactic body radiation therapy (SBRT) may be a viable treatment option for recurrent or residual pancreatic or periampullary adenocarcinoma.
- Trial name
- NCT01781728
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreaticoduodenectomy
Minimally Invasive Pancreatico-duodenectomy
Open pancreaticoduodenectomy (PD) is the standard treatment for a wide array of periampullary and pancreatic diseases including malignant and benign conditions.
- Trial name
- LPD (NCT02807701)
- Testing
- Laparoscopic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Pancreatic Cancer, Periampullary Adenocarcinoma
Capecitabine, Vorinostat, and Radiation Therapy in Treating Patients With Nonmetastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00983268
- Testing
- capecitabine, vorinostat, Radiotherapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Pancreas Cancer, Pancreas Neoplasm
The Role of the Human Microbiome in Patients After Pancreatic Resection.
The goal of this observational study is to classify patients that undergo pancreatic resection for presumed pancreatic or periampullary malignancy into high and low risk groups for postoperative complications based on…
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Adenocarcinoma, Periampullary Cancer
- Trial name
- MiPac (NCT06381882)
- Testing
- Pancreatic resection
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- St. Antonius Hospital
Periampullary Neoplasms, Pancreatic Cancer
Total Pancreatectomy With Islet Autotransplantation (TPIAT) for High-Risk Patients With Pancreatic Tumors
This is a single-center, prospective, single-arm feasibility study evaluating whether adult patients with periampullary neoplasms who are at high risk for postoperative pancreatic fistula after pancreaticoduodenectomy can be…
- Conditions
- Periampullary Neoplasms, Pancreatic Cancer, Pancreatic Neoplasms
- Trial name
- NCT07360119
- Testing
- Total Pancreatectomy with Islet Autotransplantation (TPIAT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Functional Recovery, Laparoscopy
Comparison of Functional Recovery Between Laparoscopic and Open Pancreaticoduodenectomy
Laparoscopic surgery has not changed much in safety compared with open surgery through many existing studies, and has become a procedure to help patients' recovery.
- Conditions
- Functional Recovery, Laparoscopy, Periampullary Cancer
- Trial name
- NCT03870698
- Testing
- Laparoscopic group
- Where
- South Korea
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Cancer Gi
Prophylactic EUS-guided Gastroenterostomy in Advanced Periampullary Cancers
The goal of this randomized controlled trial is to investigate the effectiveness and safety of Prophylactic EUS-gastroenterostomy (ProEUS-GE) as a preventative approach for malignant gastric outlet obstruction (MGOO) in men and…
- Trial name
- INTERCEPT (NCT05994521)
- Testing
- ERCP alone, ERCP +ProEUS-GE
- Where
- 5 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pancreatic Cancer, Common Bile Duct Diseases
A Prospective Study on the Safety and Efficacy of Robot-assisted Pancreaticoduodenectomy
Further studies are needed to investigate the prognosis and perioperative safety of patients undergoing robotic-assisted pancreaticoduodenectomy.
- Conditions
- Pancreatic Cancer, Common Bile Duct Diseases, Periampullary Carcinoma
- Trial name
- NCT05755594
- Testing
- Robot-assisted Pancreaticoduodenectomy
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of University of South China
Pancreatic Cancer, Periampullary Carcinoma
Shark Mouth Modified Pancreaticojejunostomy
Pancreaticoduodenectomy (PD) is one of the most complicated surgical procedure and one of the standard treatments for benign and malignant disease of pancreatic head and periampullary region.
- Trial name
- SMMP (NCT03366038)
- Testing
- Shark Mouth Modified Pancreaticojejunostomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Pancreatic Carcinoma
Preoperative Biliary Drainage in Resectable Pancreatic or Periampullary Cancer
The purpose of this study is to demonstrate that preoperative biliary drainage using self-expanding metal stents (SEMS) does not negatively impact overall surgical outcomes in patients undergoing pancreaticoduodenectomy for…
- Trial name
- NCT01774019
- Testing
- WallFlex™ Biliary RX Fully Covered/Uncovered Stent System
- Where
- 11 sites in United States, Australia and 7 more
- Volunteers
- 284 people
- Sponsor
- Boston Scientific Corporation
Pancreatic Cancer, Cancer of the Duodenum
Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy
Pancreatoduodenectomy carries high morbidity rates even in high-volume centers. Postoperative complications often preclude or delay adequate oral nutrition and nutritional support may be required.
- Conditions
- Pancreatic Cancer, Cancer of the Duodenum, Cholangiocarcinoma, Chronic Pancreatitis
- Trial name
- NCT01642875
- Testing
- Enteral nutrition, Oral nutrition
- Where
- Poland
- Volunteers
- 96 people
- Sponsor
- Medical University of Warsaw