Clinical trials: Perianal Fistula
Perianal Fistula
Role of MRI in Perianal Fistula
The aim of this study is to assess the diagnostic accuracy of MRI in detecting and assessment the primary fistulous tract, internal openings, secondary extensions, and associated abscesses.
- Trial name
- MRI PA fistula (NCT07510204)
- Testing
- Diagnostic imaging (MRI)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Complex Perianal Fistula
Long-term Safety and Efficacy of Adipose-derived Stem Cells to Treat Complex Perianal Fistulas in Patients Participating in the FATT-1 Randomized Controlled Trial
The purpose of this extension is to investigate and confirm the long-term (6 months) safety and efficacy of the preceding FATT-1 trial [ClinicalTrials.gov identifier: NTC00475410], which studied patients with perianal fistula…
- Trial name
- LTE (NCT01020825)
- Testing
- ASCs, Fibrin glue
- Where
- 15 sites in Spain
- Volunteers
- 148 people
- Sponsor
- Tigenix S.A.U.
Crohn's Disease
Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease
The purpose of this study is to evaluate the percentage of participants with perianal fistula healing at Week 30 in 2 different dose regimens of vedolizumab intravenous (IV) 300 milligram (mg) in participants with fistulizing…
- Trial name
- ENTERPRISE (NCT02630966)
- Testing
- Vedolizumab
- Where
- 18 sites in United States, Canada and 5 more
- Volunteers
- 34 people
- Sponsor
- Takeda
Fistula in Ano, Crohn Disease
Autologous Stem Cells in the Management of Fistulating Perianal Crohn's Disease
Crohn's disease is a chronic inflammatory condition that can affect any part of the bowel which can be controlled by a combination of medical and surgical treatments but cannot be cured.
- Trial name
- NCT06822686
- Testing
- Harvest and injection of stem cells
- Sponsor
- Oxford University Hospitals NHS Trust
Coring Out, Fistulectomy
Coring Out Fistulectomy With Closure of Internal Sphincter Opening Versus Lay Open Fistulotomy and Primary Sphincter Repair in Transsphincteric Perianal Fistula
This study aimed to compare the surgical outcomes of coring out fistulectomy with the closure of internal sphincter opening versus lay open fistulotomy (modified LIFT) and lay open fistulotomy and primary sphincter repair in…
- Conditions
- Coring Out, Fistulectomy, Internal Sphincter, Lay Open Fistulotomy
- Trial name
- NCT06478615
- Testing
- Coring out Fistulectomy with Closure of Internal Sphincter Opening, Lay Open Fistulotomy and Primary Sphincter Repair
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Inflammatory Bowel Disease, Perianal Fistula
Prevalence of Inflammatory Bowel Disease in Patients With Perianal Disease
To show that prevalence of inflammation of the small bowel in patients with anorectal disease is under-diagnosed based on colonoscopy ileoscopy alone.
- Conditions
- Inflammatory Bowel Disease, Perianal Fistula, Perianal Abscess
- Trial name
- NCT00972088
- Testing
- capsule endoscopy
- Where
- 3 sites in Israel
- Volunteers
- 26 people
- Sponsor
- Bikkur Holim Hospital
Perianal Fistula Due to Crohn's Disease
DB-3Q bmMSC-EVs in Patients With Perianal Fistulizing Crohn's Disease
This is a double-blind, randomized, placebo-controlled, sequential cohort, ascending dose clinical trial to evaluate the safety and determine the efficacy of ascending doses of DB-3Q for the treatment of Perianal Fistulizing…
- Trial name
- NCT06918808
- Testing
- DB-3Q
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Direct Biologics, LLC
Anal Fistula, Perianal Fistula
Comparison Of Surgical Outcomes Between Ligation Of Intersphincteric Fistula Tract And Fistulotomy With Seton In Perianal Fistula
This study aims to compare two commonly used surgical techniques for the treatment of perianal fistula: Ligation of the Intersphincteric Fistula Tract (LIFT) and fistulotomy with seton.
- Conditions
- Anal Fistula, Perianal Fistula, Fistula-in-ano
- Trial name
- LIFT-SETON (NCT07579715)
- Testing
- Ligation of Intersphincteric Fistula Tract (LIFT), Fistulotomy with Seton Placement
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Islamabad Medical and Dental College
Perianal Fistula, Perianal Fistula Due to Crohn's Disease
Semiflex Assisted Vacuum Therapy for Perianal Abscesses/Sinuses and Fistula: a Pilot Study
Rationale: Perianal fistulas are a common, invalidating problem for which a more effective and widely applicable treatment is necessary.
- Conditions
- Perianal Fistula, Perianal Fistula Due to Crohn's Disease, Perianal Abscess
- Trial name
- Semiflex Pilot (NCT06446635)
- Testing
- Semiflex Dome Catheter System
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Crohn's Disease
Visilizumab for Treatment of Perianal Fistulas in Crohn's Disease
The purpose of the study is to evaluate an intravenous (by injection) investigational medication to treat Crohn's disease in patients with at least one perianal fistula.
- Trial name
- NCT00267709
- Testing
- Visilizumab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Facet Biotech
Rectal Fistula
Photodynamic Therapy in Anal Fistula
Objective: Validate and analyze the results of intralesional photodynamic therapy in the treatment of complex anal fistula. Methods: Prospective observational study including patients treated for complex anal fistula who…
- Trial name
- NCT03864718
- Testing
- photodynamic therapy
- Volunteers
- 49 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Perianal Crohn's Disease
A Safety and Efficacy Study of BLI-1300 Ointment in Symptomatic Perianal Crohn's Disease
This randomized, placebo-controlled, parallel, multi-center, double-blind pilot study is designed to determine the effects of BLI-1300 ointment on perianal pain associated with active Perianal Crohn's Disease (PCD).
- Trial name
- NCT01442363
- Testing
- BLI-1300 low dose, BLI-1300 high dose
- Where
- 17 sites in United States
- Volunteers
- 4 people
- Sponsor
- Braintree Laboratories
Perianal Fistula, Transsphincteric Anal Fistula
Treatment of Lower Transsphincteric Perianal Fistula: Fistulotomy With Marsupialization vs Open Wound
This study will compare the results of marsupialization versus open wound after fistulotomy in low transsphincteric perianal fistulas.
- Trial name
- NCT04722965
- Testing
- Fistulotomy with marsupialization, Fistulotomy with open wound
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Crohn Disease
Self Screening Tool for Crohn's Perianal Fistula
This study aims to develop a self-screening tool for Crohn's perianal fistula.
- Trial name
- NCT03288961
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Kyungpook National University Hospital
Perianal Fistula
Diagnostic Value of Recto-perineal Ultrasound in Perianal Fistula
Perianal fistula is a common anal problem. It needs only surgery. MRI is the best preoperative diagnostic tool, but it is demanding as it is expensive, time consuming and needs an experienced radiologist.
- Trial name
- NCT06314945
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Zagazig University
Fistula in Ano
PRP Use in Treatment of Fistula Ano
In treatment of perianal fistula several methods are described. However, since the Hippocrates basics of surgical treatment has not changed very much.
- Trial name
- NCT04187651
- Testing
- platelet rich plasma
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uşak University
Anal Fistula
Autologous Stem Cells Derived From Lipoaspirates for the Non-Surgical Treatment of Complex Perianal Fistula
This comparative, multicentre, randomised clinical trial is designed with two parallel groups that will follow a treatment either with an autologous implant of ASCs (Adipose Derived Stem Cells) and fibrin glue (tissue adhesive…
- Trial name
- NCT00115466
- Testing
- Non-surgical autologous implant of ASCs
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cellerix
Crohn Disease, Fistula Perianal
Efficacy of Cx601 (Darvadstrocel) for the Treatment of Perianal Fistulizing Crohn's Disease
The use of mesenchymal stem cells is considered a novel and promising therapeutic option for patients with perianal fistulizing Crohn's disease.
- Trial name
- NCT05322057
- Testing
- Darvadstrocel
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Crohn's Disease
A Survey of Darvadstrocel in People With Crohn's Disease
This study is a survey in Japan of Darvadstrocel injection used to treat Crohn's disease people with complicated anal fistula. The study sponsor will not be involved in how the participants are treated but will provide…
- Trial name
- J-INSPIRE (NCT05113095)
- Testing
- Darvadstrocel
- Where
- Japan
- Volunteers
- 275 people
- Sponsor
- Takeda
Perianal Fistula, Hemorrhoids
Adding Ketamine to Low Dose Bupivacaine in Saddle Block for Perianal Surgery
Evaluation of the anesthetic quality and analgesic efficacy of adding ketamine to intrathecal bupivavaine in selective saddle block for perianal surgery.
- Trial name
- NCT03264430
- Testing
- Ketamine, bupivacaine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Esam Eldin Mohamed Abdalla