Clinical trials: Periapical; Infection
Periodontitis, Gingivitis
Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control
The goal of this study is to learn if dental infection control treatment delivered to older adult nursing home residents at their place of residence will result in : improved dental health reduced risk of pneumonia better glucose…
- Conditions
- Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections
- Trial name
- NHOralHealth (NCT06890676)
- Testing
- Comprehensive Oral Evaluation, Intraoral Complete Radiographic Series, • Teledentistry-synchronous and asynchronous
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Missouri Department of Health and Senior Services
Intervention Studies, ASA Physical Status I
Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications: 1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite 2. Calcium Silicate 3.
- Conditions
- Intervention Studies, ASA Physical Status I, Intracanal Medication, Periapical Abscess
- Trial name
- RCT (NCT07641933)
- Testing
- Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periapical Periodontitis, Polymerase Chain Reaction
The Effect of Ca(OH)2 in Apical Periodontitis
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Intracanal Medicament, Enterococcus Faecalis Infection
- Trial name
- NCT04978545
- Testing
- calciumhydroxide, intracanal medicament, chlorhexidine, intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Necrotic Pulp, Periapical; Infection
Volume Assessment of the Periapical Healing Following Regenerative Endodontic Procedures Using Cone- Bean Computed Tomography
3D volume assessment was done to evaluate the periapical healing following REPs in mature teeth.
- Trial name
- NCT04646538
- Testing
- Regenerative Endodontics Procedures (REPs)
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Periapical; Infection
Radiographic Assessment of the Healing Pattern Associated With Periradicular Endodontic Microsurgery
Endodontic periradicular microsurgery is a dental procedure to treat apical periodontitis in cases in which healing has not occurred after non-surgical treatment or if it is not feasible.
- Trial name
- NCT06031792
- Testing
- Piezo endodontic surgery, Conventional endodontic surgery
- Where
- 2 sites in Jordan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Periapical Periodontitis, Root Canal Infection
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using EndoActivator for irrigation activation.
- Trial name
- NCT06339905
- Testing
- Sonic Activation with EndoActivator, Control Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Apical Periodontitis, Pulp Disease, Dental
A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment
The goal of this observational is study is to develop a protocol for root canal biofilms disinfection using a clinically approved and commercially available iron oxide nanoparticle formulation Ferumoxytol/H2O2 treatments.
- Trial name
- NCT06110494
- Testing
- Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Periapical Periodontitis, Root Canal Infection
Efficacy of Apical Preparation With Passive Ultrasonic Irrigation in Reducing Intracanal Bacteria
This study evaluates intracanal bacterial load in molar teeth with chronic apical periodontitis before and after root canal shaping with two different apical enlargement sizes and ultrasonic irrigation activation.
- Trial name
- NCT07005219
- Testing
- Root canal shaping with One Curve Mini #25/0.4 and passive ultrasonic irrigation, Root canal shaping with One Curve Mini #35/0.4 and passive ultrasonic irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Apical Periodontitis, Dental Pulp Necrosis
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment.
- Conditions
- Apical Periodontitis, Dental Pulp Necrosis, Root Canal Infection
- Trial name
- CHITO-PRE RCT (NCT07048028)
- Testing
- Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ESRA DAĞCI
Periapical Abscess
Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant
Investigators observed the clinical and radiographic healing of periapical lesion using Chitosan mixed with calcium hydroxide and compared it with triple antibiotic paste when used as intracanal medicament in 3months, 6 months…
- Trial name
- NCT04319575
- Testing
- root canal treatment and intracanal medicament
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Tooth Extraction, Periapical Infections
Cortical Lamina for Alveolar Ridge Preservation
This randomized controlled clinical trial aims to evaluate the efficacy of placing a cortical lamina between the elevated flap and buccal bone plate following tooth extraction for preserving alveolar ridge dimensions.
- Conditions
- Tooth Extraction, Periapical Infections, Tooth Fracture, Periodontal Disease, AVDC Stage 4
- Trial name
- Lamina (NCT07231874)
- Testing
- Cortical Lamina Technique, Natural Healing (Control)
- Where
- Cuba
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ARDEC Academy
Periapical Abscess
Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy
The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as root canal irrigant in Pulpectomy…
- Trial name
- NCT02943759
- Testing
- Neem leaf extract, Chlorhexidine gluconate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Periodontitis, Root Canal Infection
Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments
This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis.
- Conditions
- Periapical Periodontitis, Root Canal Infection, Intracanal Medicaments
- Trial name
- NCT07671326
- Testing
- Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Root Canal Infection, Periapical; Infection
Bacteria Elimination in Retreatment Cases Using Different Disinfection Techniques
Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.It has been stated that the one of the main cause of posttreatment…
- Trial name
- NCT03750162
- Testing
- VDW Ultra, AMD picasso, ProtaperNext X3 gutta-percha
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Apical Periodontitis, Postoperative Pain
Cryotherapy on Inflammatory Profile and Postoperative Pain Levels in Endodontic Infections
The aim of this study is to evaluate the effects of cryotherapy applications on the inflammatory cytokine and collagenase matrix metalloproteinase levels during root canal treatment and postoperative pain intensity and incidence.
- Conditions
- Apical Periodontitis, Postoperative Pain, Cytokine Levels
- Trial name
- NCT04798144
- Testing
- Distilled water irrigation kept at 2.5°C degree, Distilled water irrigation kept at room temperature
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Periapical Periodontitis, Polymerase Chain Reaction
Quantitative Assessment of the Efficacy of Sweeps Laser Activation Systems
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Enterococcus Faecalis Infection
- Trial name
- NCT05718596
- Testing
- sweeps laser to use irrigation activation, PUI to use irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Pain, Postoperative, Periapical; Infection
Clinical and Radiographic Evaluation of Zinc Oxide-Propolis Mixture Versus Modified Triple Antibiotic Paste in LSTR
The aim of this study is to evaluate and compare the clinical effectiveness of zinc oxide-propolis mixture with triple antibiotic paste in LSTR as root canal filling material in necrotic primary molars.
- Trial name
- NCT06158451
- Testing
- Zinc oxide propolis, Modified triple antibiotic paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, Root Canal Infection
Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal
The aim of the study is first, to evaluate the clinical antibacterial efficacy of two different NaOCl concentrations (2,5% and 5%) under a predefined irrigant flow rate in teeth with pulp necrosis and apical periodontitis by…
- Trial name
- ENDOA (NCT06949176)
- Testing
- Root canal tratment using mecchanical and chemical preparation., Sodium Hypochlorite., Hydrogen peroxide.
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Periapical; Infection
PRF and Bone Graft in Endodontic Surgeries
AIM: The aim of this study was to compare and evaluate the radiographic healing in patients undergoing apical surgery, using Freeze dried mineralized bone allograft and Platelet-rich Fibrin.
- Trial name
- NCT04377698
- Testing
- Platelet Rich Fibrin, FDBA
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saraswati Dental College
Root Canal Infection, Periapical Periodontitis
Sealer-Based Obturation With AH Plus Bioceramic Sealer vs. Warm Vertical Compaction With AH Plus
The goal of this clinical trial is to assess the efficacy and outcome of sealer-based obturation (SBO) using a new calcium silicate sealer in comparison with warm vertical compaction (WVC) using a resin-based sealer, which is the…
- Conditions
- Root Canal Infection, Periapical Periodontitis, Periapical Diseases
- Trial name
- NCT05763420
- Testing
- AH Plus Bioceramic Sealer, AH Plus Sealer (resin-based)
- Where
- Kuwait
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Kuwait