Clinical trials: Periapical Disease
Apical Periodontitis, Post Endodontic Pain
Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial
Background Apical periodontitis (AP) is an inflammatory condition of the periapical tissues. The Symptomatic Apical periodontitis (SAP) represents the active phase of the disease, presenting with pain and tenderness.
- Conditions
- Apical Periodontitis, Post Endodontic Pain, Periapical Healing, Inflammatory Biomarkers
- Trial name
- NCT07762599
- Testing
- silver nanoparticles reinforced double antibiotic paste, Double Antibiotic Paste
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
Apical Periodontitis
2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament
This is a Pilot Phase III single-blind randomized controlled clinical trial in patients, aged 18 years and older, presenting with symptoms of apical periodontitis.
- Trial name
- NCT03700788
- Testing
- Chlorhexidine, Calcium Hydroxide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Endodontic Treatment, Pulp Necrosis
Dexamethasone Treatment for Patients Undergoing Endodontics
This Phase IV randomized clinical trial (RCT) evaluated the efficacy of preoperative administration of a single 4 mg oral dose of dexamethasone in reducing postoperative pain and inflammation following endodontic treatment.
- Conditions
- Endodontic Treatment, Pulp Necrosis, Periapical Lesions, Postoperative Pain
- Trial name
- (DTPE-RCT) (NCT06906315)
- Testing
- Dexamethasone 4 mg, Ibuprofen group
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Salamanca
Apical Periodontitis
Association of Endodontic Infection With Cardiovascular Disease.
Chronic inflammation plays a crucial role in the genesis of atherosclerosis and at the same time promotes acute cardiovascular events.
- Trial name
- NCT03425383
- Testing
- FMD and c-IMT
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Obesity, Periodontitis
Evaluation of the Dental Health Condition in Obesity Patients Before and After Bariatric Surgery
The aim of this study is to investigate whether there was an association between obesity and periodontitis, tendency to caries and periapical lesions.
- Conditions
- Obesity, Periodontitis, Caries, Periapical Lesion
- Trial name
- NCT00531154
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Periapical Periodontitis, Periapical Abscess
A Retrospective Cohort Study on the Non-Surgical Treatment of Periapical Inflammatory Lesions With Vitapex Paste
Background: Periapical inflammation is a common clinical condition, classified into periapical periodontitis, periapical granuloma, and periapical cyst.
- Conditions
- Periapical Periodontitis, Periapical Abscess, Periapical Radiolucency
- Trial name
- NCT07907367
- Testing
- Vitapex Paste
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Affiliated Hospital of Jinggangshan University
Dentoalveolar Abscess
Systemic and Local Antimicrobials in the Management of Dental Abscess in Children
Dental infections originating in the teeth are routinely managed systemically with a course of oral antibiotics, while severe forms are managed with intravenous antibiotics.
- Trial name
- NCT03761264
- Testing
- Odontopaste®, Pulpdent, Amoxicillin
- Where
- Malaysia
- Volunteers
- 55 people
- Sponsor
- University of Malaya
Pulpitis, Periapical Periodontitis
Comparative Evaluation of Different File Systems in Postoperative Pain
Postoperative pain is a frequent complication associated with root canal treatment. The apical extrusion of irrigant and debris, including bacteria and necrotic tissue, may lead to postoperative pain, periapical inflammation, and…
- Conditions
- Pulpitis, Periapical Periodontitis, Necrotic Pulp
- Trial name
- NCT03708081
- Testing
- ProTaper Next, TF Adaptive
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bulent Ecevit University
Root Canal Infection, Periapical Diseases
Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion
The goal of this observational study is to define the role of apical shaping and irrigation activation on root canal cleanliness.
- Conditions
- Root Canal Infection, Periapical Diseases, Periapical; Infection, Endodontic Disease
- Trial name
- NCT06035185
- Testing
- apical shaping size
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Caries,Dental, Apical Periodontitis
Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General
The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine…
- Trial name
- NCT04104789
- Testing
- Kovanaze Nasal Spray, Articaine Injection
- Sponsor
- Virginia Commonwealth University
Apical Periodontitis
Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis
Apical periodontitis is a chronic inflammatory disease caused by bacterial infection of the root canal system. Although mechanical cleaning and shaping reduce most microorganisms, bacteria may persist in areas that are difficult…
- Trial name
- NCT07351682
- Testing
- Calcium Hydroxide (Ca(OH)2) Intracanal Medication, Calcium Hydroxide + Iodoform (Metapex), Calcium Hydroxide + Betamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Medipol University
Apexification, Apexogenesis
Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma
Children often damage their front teeth. In approximately 6% of cases, the nerve inside the affected tooth dies (becomes 'non-vital') and natural root development stops.
- Conditions
- Apexification, Apexogenesis, Pulp Necrosis, MTA
- Trial name
- NCT01817413
- Testing
- Mineral trioxide aggregate, Revascularisation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Liverpool
Endodontic Treatment, Periapical Diseases
Effectiveness of Photodynamic Therapy in the Disinfection of Root Canals in Patients With Apical Lesion
The object of the present study is to compare the effectiveness of conventional endodontic treatment with that of endodontic treatment combined with Photodynamic Therapy (PDT) in patients with apical lesion.
- Trial name
- PDT (NCT05916859)
- Testing
- Group 2 PDT (10 s), Group 3 PDT 20 s
- Where
- Chile
- Volunteers
- 159 people
- Sponsor
- Universidad de La Frontera
Root Canal Therapy, Periapical Periodontitis
Comparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth
To the best of our knowledge, only two studies are available which have provided a direct comparison between outcome of nonsurgical retreatment and endodontic surgery. The results of the two studies are contradictory in nature.
- Trial name
- NCT03918733
- Testing
- surgical treatment, Non surgical retreatment
- Where
- India
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Endodontic Disease, Dental Implant Failed
Retreat or Replace: Retrospective Investigation on a Cohort of Local Patients
Introduction: To evaluate the survival and success rate of premolars with a previous root canal treatment which underwent to non-surgical retreatment or to extraction and implant replacement.
- Conditions
- Endodontic Disease, Dental Implant Failed, Periapical Diseases
- Trial name
- NCT06250114
- Testing
- Retreatment, extraction implant
- Volunteers
- 130 people
- Sponsor
- University of Bologna
Apical Periodontitis
Accuracy of ERCLMDs in Teeth With Apical Periodontitis
The aim of this in vivo study is to evaluate the influence of apical periodontitis (AP) on the accuracy of Dentaport ZX, Raypex 5, and i-Root electronic root canal length measurement devices.
- Trial name
- ERCLMDs (NCT01904552)
- Testing
- Electronic Root Canal Length Measurement Device
- Where
- Iran
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Apical Periodontitis
Effect of Smear Layer on Endodontic Outcome
This study evaluated the effect of removal of smear layer on the success of primary root canal treatment.Patients requiring primary root canal treatment in mature mandibular first and second molars were allocated to either smear…
- Trial name
- NCT03277404
- Testing
- Root canal treatment with smear layer removal, Root canal treatment without smear layer removal
- Volunteers
- 86 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis, Postoperative Pain
Effect of Integrated Apex Locator Motor Modes on Postoperative Pain in Endodontic Retreatment
This randomized controlled clinical trial aimed to evaluate the effect of different integrated electronic apex locator (EAL) modes on postoperative pain following nonsurgical endodontic retreatment.
- Conditions
- Apical Periodontitis, Postoperative Pain, Endodontic Retreatment
- Trial name
- EAL-Pain (NCT07527897)
- Testing
- Electronic Apex Locator, Integrated Apex Locator Motor
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people
- Sponsor
- Recep Tayyip Erdogan University
Periapical Periodontitis
Premixed Bioceramic Putty as an Apical Plug in Immature Anterior Permanent Teeth
Following the randomization procedure, children will be divided into 2 groups (25 immature anterior permanent incisors in each group): Group I will be treated with MTA as apical plug while group II will be treated with Premixed…
- Trial name
- NCT06322979
- Testing
- Mineral trioxide aggregate, Premixed Bioceramic Putty
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Periapical Diseases, Periapical Periodontitis
Postoperative Pain After Conservative Root Canal Preparation
The goal of this clinical trial is to compare the pain experienced by healthy participants after root canal treatment with small versus large root canal sizes. The main questions it aims to answer are: 1.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Postoperative Pain, Pulp Necroses
- Trial name
- NCT06545773
- Testing
- Root Canal Treatment with ProTaper Next Nickel-Titanium File (PTN), Root Canal Treatment withTruNatomy Nickel-Titanium File (TN)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University