Clinical trials: Periapical Disease
Pulp Necrosis, Apical Periodontitis
Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment.
Bacteria inside the root canal are a major cause of tooth infections. If they are not completely removed, the infection may continue even after root canal treatment.
- Trial name
- NCT07688005
- Testing
- Sodium Hypochlorite 3% Solution, Emblica officinalis Solution
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Root Canal Infection, Periapical Abscess
Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.
The basic aim of root canal treatment is to reduce the microbial content and prevent further recontamination in the canal. Every tooth has a variable, complex canal anatomy consisting of ramifications, accessory and lateral…
- Conditions
- Root Canal Infection, Periapical Abscess, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT05778227
- Testing
- Ethylene Diamine Tetra Acetic acid, smearOFF, Etidronic acid /sodium hypochlorite
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Apical Periodontitis
Association of Endodontic Infection With Cardiovascular Disease.
Chronic inflammation plays a crucial role in the genesis of atherosclerosis and at the same time promotes acute cardiovascular events.
- Trial name
- NCT03425383
- Testing
- FMD and c-IMT
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis
In Vivo Assessment of Endodontics Procedures
In view of the wide variety of mechanized endodontic instrumentation systems, the ideal would be that the choose of this system based on the anatomical characteristics of the canal and the biological precepts.
- Trial name
- NCT03243357
- Testing
- TF Adaptive (First Apical Binding File), TF Adaptive (Control)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of Uberlandia
Root Canal Treatment, Obturation Quality
Diagnostic Accuracy of a Deep Learning Framework for Automated Evaluation of Root Canal Obturation Quality From Periapical Radiographs
This study aims to develop and evaluate an artificial intelligence (AI)-based system that can automatically assess the quality of root canal fillings using dental X-ray images.
- Trial name
- NCT07684482
- Testing
- Deep learning model
- Volunteers
- 490 people
- Sponsor
- Cairo University
Apical Periodontitis
Comparison of Sonic and Ultrasonic Activation on Healing of Apical Periodontitis
The goal of this clinical trial is to learn whether two different irrigation activation methods - passive ultrasonic irrigation (PUI) and sonic activation - help periapical healing in root canal treatments of single-rooted teeth…
- Trial name
- SONIC-ULTRA (NCT07249450)
- Testing
- Sonic Activation Irrigation, Passive Ultrasonic Irrigation (PUI), Conventional Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hilal Çuhadar Beşiroğlu
Periapical Periodontitis
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional…
- Trial name
- RanoKure (NCT03102879)
- Testing
- Regenerative Endodontic Procedure, Conventional Root Canal Treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidad de los Andes, Chile
Apical Periodontitis
Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement
The goal of this clinical trial is to conduct an in vivo study that allows to compare the periapical healing process of 3 different sealing cements through CBCT, as well as implement the evaluation of these lesions through…
- Trial name
- NCT06482593
- Testing
- Zinc-Oxide Eugenol Sealer, AH-Plus Epoxy Resin Sealer, Bio-C Sealer
- Where
- Colombia
- Volunteers
- 72 people
- Sponsor
- Institucion Universitaria Colegios de Colombia
Symptomatic Periapical Periodontitis
Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain
The aim of this prospective, randomized, placebo controlled study is to evaluate the effect of amoxicillin/clavulanic acid combination on post-operative pain and swelling in adult patient with symptomatic apical periodontitis.
- Trial name
- NCT03007342
- Testing
- Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet
- Volunteers
- 78 people
- Sponsor
- Cairo University
Periapical Diseases
Efficiency of Diode Laser Activated Irrigation on Healing of Periapical Tissues
Study is a Randomized clinical trial conducted at Endodontic department- Ain Shams university Cairo. Egypt. 24 eligible patients were selected and included in the study to compare healing ability of diode laser activated…
- Trial name
- NCT04311905
- Testing
- Diode laser
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Primary Apical Periodontitis, Root Canal Infection
Bacterial Profiles in Primary Apical Periodontitis Using 16S rRNA PCR
This pilot randomized clinical study aims to compare bacterial profiles in symptomatic and asymptomatic primary apical periodontitis using 16S rRNA polymerase chain reaction sequencing.
- Conditions
- Primary Apical Periodontitis, Root Canal Infection, Endodontic Infection
- Trial name
- NCT07637305
- Testing
- 3% Sodium Hypochlorite Irrigation with Ultrasonic Activation, 5.25% Sodium Hypochlorite Irrigation with Ultrasonic Activation
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Hasanuddin University
Necrotic Pulp With Symptomatic Apical Periodontitis
The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal Treatment of Non-vital Mandibular First Molar With Periapical Lesion.
The goal of this clinical trial is to learn which rinsing of root canals method works best to lower pain after a root canal in adults.
- Trial name
- NCT07623629
- Testing
- root canal treatment
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Periapical Periodontitis, Bacterial Infections
Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections
This study aims to evaluate an endodontic treatment protocol using adjunctive steps for disinfection of teeth with primary endodontic infections.
- Trial name
- NCT03537664
- Testing
- Root canal preparation, Intracanal medication
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo
Oral Health, Dental Caries
The Use of Artificial Intelligence in the Dental X-rays Analysis
This cross-sectional study aims to perform a population-based assessment of the incidence of decay, dental fillings, root canal fillings, endodontic lesions, implants, implant and dental abutment crowns, pontic crowns, and…
- Conditions
- Oral Health, Dental Caries, Periapical Diseases, Tooth Loss
- Trial name
- NCT06258798
- Testing
- Taking a dental X-ray
- Where
- Poland
- Volunteers
- 1,025 people
- Sponsor
- Hospital of the Ministry of Interior, Kielce, Poland
Pulp and Periapical Tissue Disease
Comparative Analysis of Diagnostic Accuracy and Case Difficulty Assessment of Three Large Language Models
This prospective, blinded diagnostic accuracy study aims to compare the performance of three large language models-ChatGPT (GPT-5.5 Pro), Gemini 3.1 Pro, and Claude Opus 4.7-in endodontic diagnosis and case difficulty assessment.
- Trial name
- NCT07732985
- Testing
- ChatGPT (GPT-5.5 Pro), Gemini 3.1 Pro, Claude Opus 4.7
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Teeth With Apical Periodontitis
Evaluation of the Aloe Vera Anti-inflammatory Effect on Apical Periodontitis.
The goal of this clinical trial is to evaluation aloe vera as intracanal medication anti-inflammatory also inter-appointment pain incidence compared with calcium hydroxide.
- Trial name
- NCT07826091
- Testing
- Aloe vera gel, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Ain Shams University
Focal Infection, Dental
AUGMENTIN™ in Dental Infections
In clinical practice, amoxicillin + clavulanic acid is widely used in the treatment of odontogenic infection. Therefore, this study is designed to generate data to support its use by demonstrating efficacy, safety and…
- Trial name
- AUGDENT (NCT02141217)
- Testing
- Amoxicillin/clavulanate, Clindamycin
- Where
- 15 sites in Malaysia, Philippines and 2 more
- Volunteers
- 472 people
- Sponsor
- GlaxoSmithKline
Apical Periodontitis
Lesion Healing After Regenerative Endodontic Treatment
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies.
- Trial name
- NCT06843850
- Testing
- regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periapical Periodontitis, Treatment Outcome
2-year Treatment Outcomes of Teeth Estimated by Means of Periapical and Endodontic Status Scale
Objectives: Evaluation of endodontic treatment success is largely based on radiographical assessment of anatomical and treatment-related parameters of teeth with apical periodontitis (AP).
- Trial name
- NCT04495270
- Testing
- Analysis of treatment outcomes of teeth with apical periodontitis based on cone-beam computed tomography and estimated by means of Periapical and Endodontic Status Scale"
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Pulpal and Periapical Diseases
Diagnostic Accuracy of Educated Large Language Models in Endodontic Diagnosis and Case Difficulty Assessment
This diagnostic test accuracy (DTA) study aims to evaluate the diagnostic performance of educated large language models (Educated ChatGPT (GPT-5.5 Pro), Educated Gemini 3.1 Pro, and Educated Claude Opus 4.7) in endodontic…
- Trial name
- NCT07706894
- Testing
- ChatGPT, Gemini, Calude
- Volunteers
- 349 people
- Sponsor
- Cairo University