Clinical trials: Periapical Healing
Necrotic Pulp, Periapical; Infection
Volume Assessment of the Periapical Healing Following Regenerative Endodontic Procedures Using Cone- Bean Computed Tomography
3D volume assessment was done to evaluate the periapical healing following REPs in mature teeth.
- Trial name
- NCT04646538
- Testing
- Regenerative Endodontics Procedures (REPs)
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pulp and Periapical Tissue Disease
Gingival Crevicular Fluid Biomarkers and Healing After Root Canal Treatment in Asymptomatic Apical Periodontitis
This prospective observational cohort study will evaluate whether changes in gingival crevicular fluid osteoprotegerin (OPG) , RANKL/OPG ratio ,IL10,IL8and CxCL10 after primary nonsurgical root canal treatment are associated with…
- Trial name
- NCT07468643
- Testing
- Primary Nonsurgical Root Canal Treatment
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Rheumatoid Arthritis AND Apical Periodontitis
Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study
SUMMARY TITLE: "Effect of endodontic treatment on inflammatory markers, disease activity and periapical healing in rheumatoid arthritis patients with apical periodontitis" RATIONALE: Chronic inflammation plays a pivotal role in…
- Trial name
- NCT06433232
- Testing
- ROOT CANAL TREATMENT
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Diseases, Periapical Cyst
The Impact of Root End Filling Material Type and the Application of Bone Graft on Healing of Periapical Tissues After Endodontic Microsurgery (A Clinical Randomized Controlled Trial)
The goal of this triple blinded randomized clinical trial is to evaluate the effect of combining different bioactive root end filling materials with composite bone graft (xenogeneic mixed with autogenous bone fragments) on the…
- Trial name
- NCT05943769
- Testing
- Apical microsurgery
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Apical Cyst
Examining the Effect of Different Filling Techniques on Healing in Lesional Teeth
Microorganisms are an important factor in the development of periradicular diseases. The goal of non-surgical endodontic treatment is to eliminate microorganisms and their byproducts from the root canal system and to create an…
- Trial name
- NCT06384014
- Testing
- retrograde and orthograde root canal filling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Asymptomatic Irreversible Pulpitis
Effect of Apical Third Enlargement to Different Taper and Master Apical Preparation Size on Periapical Healing and Postoperative Pain After Primary Single Sitting Non Surgical Root Canal Treatment
To Determine Effect Of Apical Third enlargement To Different Taper And Master Apical Preparation Size On Periapical Healing And Postoperative Pain After Primary Single Sitting Non Surgical Root Canal Treatment : A Randomized…
- Trial name
- NCT07166679
- Testing
- root canal treatment with 2% taper, root canal treatment with 4% taper, root canal treatment with 6 %taper
- Where
- India
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Effects of the Elements
Healing Assessment of Osseous Defects After Surgical Removal of Periapical Lesions
recruited patients with periapical lesions will be divided into three groups and surgically treated with three types of bone graft (hydroxyappatite, nanohydroxyappatite and PRF WITH NANOHYDROXTAPPATITE) and then evaluated for…
- Trial name
- NCT05100615
- Testing
- surgery
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Minia University
Endodontic Inflammation
Evaluation of the Effect of Different Irrigation Activation Methods During Endodontic Retreatment
The persistent and secondary intraradicular infections are the primary causes of post-treatment disease following endodontic treatment of any tooth.
- Trial name
- NCT07779148
- Testing
- Xp Finisher R file
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Minia University
Periapical Periodontitis, Endodontic Microsurgery
Healing After Endodontic Microsurgery Using a Rotary Bur Versus Piezoelectric Unit for Osteotomy and Root Resection
The goal of this clinical trial is to compare bone healing after using apical tooth microsurgery to remove root end infection, either by use of rotary burs for cutting bone and root end, or by use of piezoelectric surgery for the…
- Conditions
- Periapical Periodontitis, Endodontic Microsurgery, Osteotomy
- Trial name
- BURVSPIEZO (NCT07197658)
- Testing
- endodontic microsurgery / rotary bur osteotomy, Endodontic microsurgery / piezo osteotomy, Endodontic microsurgery / bone window
- Where
- 2 sites in Greece
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Periapical Lesions
Guided Tissue Regeneration in the Healing of Through and Through Lesions
Study Title: Effects of Guided Tissue Regeneration on the Healing of Through \& Through Periradicular Lesions - A Randomized Controlled Study Rationale: Through and through defects found to be difficult to heal without GTR…
- Trial name
- NCT03284736
- Testing
- Resorbable membrane, periapical surgery without membrane
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Lesions
Platelet Rich Plasma in Healing of Through and Through Periradicular Lesions
Title : Evaluation of the efficacy of Platelet Rich Plasma (PRP) in healing of through and through lesions Rationale: Bone replacement analogues have been used in the healing after periapical surgery.
- Trial name
- NCT03430557
- Testing
- PRP, periapical surgery without PRP
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Diseases, Periapical Periodontitis
Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars
Targeted endodontic microsurgery represents precise and advanced approach to resolving persisting chronic periapical periodontitis after non- surgical root canal treatment.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Periapical Cyst, Periapical Granuloma
- Trial name
- NCT06643676
- Testing
- Targeted Endodontic Microsurgery Using 3d Printed surgical guide using the patient's CBCT data, Conventional Endodontic Microsurgery with a free hand procedure using bur and CBCT analysis
- Where
- India
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis
Comparison of Sonic and Ultrasonic Activation on Healing of Apical Periodontitis
The goal of this clinical trial is to learn whether two different irrigation activation methods - passive ultrasonic irrigation (PUI) and sonic activation - help periapical healing in root canal treatments of single-rooted teeth…
- Trial name
- SONIC-ULTRA (NCT07249450)
- Testing
- Sonic Activation Irrigation, Passive Ultrasonic Irrigation (PUI), Conventional Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hilal Çuhadar Beşiroğlu
Apical Lesion
The Effect of Injectable Platelet Rich Fibrin on Apical Lesion Healing
In recent years, the use of autologously obtained blood products that stimulate cell proliferation, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), has become increasingly widespread.
- Trial name
- NCT07876427
- Testing
- i-PRF, root canal treatment and intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hande Has Elçi
Periapical Diseases
Efficiency of Diode Laser Activated Irrigation on Healing of Periapical Tissues
Study is a Randomized clinical trial conducted at Endodontic department- Ain Shams university Cairo. Egypt. 24 eligible patients were selected and included in the study to compare healing ability of diode laser activated…
- Trial name
- NCT04311905
- Testing
- Diode laser
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periapical Diseases, Endodontic Disease
Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication
The recovery of periapical defects linked to periodontal communication frequently yields less satisfactory results. Numerous studies and case reports have highlighted the notable success achieved through the application of guided…
- Trial name
- NCT06643663
- Testing
- Endodontic Micro-Surgery
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical; Infection
PRF and Bone Graft in Endodontic Surgeries
AIM: The aim of this study was to compare and evaluate the radiographic healing in patients undergoing apical surgery, using Freeze dried mineralized bone allograft and Platelet-rich Fibrin.
- Trial name
- NCT04377698
- Testing
- Platelet Rich Fibrin, FDBA
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saraswati Dental College
Apical Periodontitis
Effect of Passive Ultrasonic Irrigation Versus Needle Irrigation on Postoperative Pain and Periapical Healing
The aim of this study is to compare the effect of passive ultrasonic irrigation versus needle irrigation on post-operative pain and healing in patients with permanent posterior teeth with apical periodontitis treated in a single…
- Trial name
- NCT02913937
- Testing
- Passive ultrasonic irrigation, Endodontic needle
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain Management
Comparing the Effectiveness of Hyalone and Calcium Hydroxide in Reducing Post-operative Pain and Promoting Periapical Healing.
This protocol presents a randomized clinical trial comparing Hyalone (hyaluronic acid) with calcium hydroxide as intracanal medicaments in mandibular first molars with necrotic pulp and symptomatic apical periodontitis.
- Trial name
- HCPH (NCT07821866)
- Testing
- Hyalone, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Periapical Abscess
Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant
Investigators observed the clinical and radiographic healing of periapical lesion using Chitosan mixed with calcium hydroxide and compared it with triple antibiotic paste when used as intracanal medicament in 3months, 6 months…
- Trial name
- NCT04319575
- Testing
- root canal treatment and intracanal medicament
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital