Clinical trials: Periapical Periodontitis
Apical Periodontitis, Postoperative Pain
Cryotherapy on Inflammatory Profile and Postoperative Pain Levels in Endodontic Infections
The aim of this study is to evaluate the effects of cryotherapy applications on the inflammatory cytokine and collagenase matrix metalloproteinase levels during root canal treatment and postoperative pain intensity and incidence.
- Conditions
- Apical Periodontitis, Postoperative Pain, Cytokine Levels
- Trial name
- NCT04798144
- Testing
- Distilled water irrigation kept at 2.5°C degree, Distilled water irrigation kept at room temperature
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Apical Periodontitis, Postoperative Pain
The Effect of Using Octenidine Hydrochloride as a Final Irrigation Solution on Teeth With Asymptomatic Apical Periodontitis on Postoperative Pain and Treatment Success: A Prospective Randomized Clinical Study
This single-centre, randomized, parallel-group clinical trial compared two commonly used final irrigants in single-visit root canal treatment: octenidine dihydrochloride (OCT) and chlorhexidine (CHX).
- Trial name
- NCT07173725
- Testing
- Octenidine dihydrochloride 0.1%, Chlorhexidine 2%
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Bezmialem Vakif University
Chronic Apical Periodontitis
The Aim of This Study is to Evaluate the Relationship Between Genetic Polymorphisms and Periapical Lesion Healing in Individuals With Chronic Apical Periodontitis at Clinical and Radiological Levels.
Chronic apical periodontitis is a chronic inflammatory condition characterized by periapical tissue destruction and alveolar bone resorption as a result of the host response to pulpal infection, often presenting asymptomatically.
- Trial name
- NCT07542223
- Testing
- single nucleotide polymorphism
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ataturk University
Endodontic Disease, Periapical Diseases
Comparison of Clinical Outcomes Between GentleWave® and Biolase®
Introduction: In the US, 15 million root canal treatments (RCTs) are carried out annually. Success rates decrease with conventional chemo-mechanical root canal preparation techniques used on teeth with periapical radiolucencies…
- Conditions
- Endodontic Disease, Periapical Diseases, Periapical Periodontitis, Root Canal Infection
- Trial name
- NCT05555043
- Testing
- Irrisafe ip, GentleWave System, Waterlase iPlus
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 2, Apical Periodontitis
Association of Apical Periodontitis With Systemic Level of Inflammatory Markers : A Longitudinal Intervention Study
While cross-sectional studies have reported a significant association between diabetes and Apical Periodontics, prospective studies are scarce.
- Trial name
- NCT05814965
- Testing
- endodontic treatment in the form of root canal treatment, endodontic treatment, assessment of inflammatory marker
- Where
- India
- Volunteers
- 280 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Diseases
Effect of Intracanal Medicaments on Post-Operative Pain in Symptomatic Apical Periodontitis: An RCT
Comparison of different intracanal medicaments during root canal treatment to assess their effect on post-operative pain in teeth with Symptomatic Apical Periodontitis
- Trial name
- NCT07123792
- Testing
- Calcium Hydroxide (20%), Chlorhexidine Gel (2%), Modified Triple Antibiotic Paste
- Where
- Pakistan
- Volunteers
- 480 people
- Sponsor
- HITEC-Institute of Medical Sciences
Apical Periodontitis
Clinical and Radiographic Success of Regeneration Using Injectable Platelet Rich Fibrin
Study aimed at assessing the clinical and radiographic success of pulp regeneration using injectable platelet-rich fibrin in mature permanent molars with apical periodontitis versus root canal treatment using Gutta Percha (GP)…
- Trial name
- NCT06086249
- Testing
- Regeneration using Injectable platelet-rich fibrin, Root canal treatment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, Postoperative Pain
Sealers in Chronic Apical Lesions
This clinical study evaluated whether different root canal sealers influence postoperative pain and early periapical healing in patients with apical periodontitis.
- Conditions
- Apical Periodontitis, Postoperative Pain, Periapical Healing
- Trial name
- NCT07339579
- Testing
- Root Canal Treatment With Sealapex, Root Canal Treatment With MTA Fillapex, Root Canal Treatment With AH Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Apical Periodontitis
Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients.
Periodontal health may jeopardize the success of endodontic treatment.Intraorifice barrier apart from enhancing probability of success of endodontic treatment may also augment periodontal therapy as intra pulpal infection is…
- Trial name
- NCT03711942
- Testing
- Intra orifice barrier, Base, Control
- Volunteers
- 90 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Periodontitis
Antibacterial Effectiveness of Two Root Canal Irrigants
The aim of this randomized clinical trial is to compare the antibacterial effects of 1% sodium hypochlorite (NaOCl) and 2% chlorhexidine gluconate (CHX) during retreatment of teeth with apical periodontitis (AP).
- Trial name
- NCT02747082
- Testing
- Retreatment of root-filled teeth with infection
- Where
- Norway
- Volunteers
- 49 people
- Sponsor
- University of Oslo
Symptomatic Apical Periodontitis, Postoperative Pain
Photobiomodulation After Nonsurgical Root Canal Treatment
This randomized, double-blind controlled clinical trial will evaluate whether adjunctive photobiomodulation improves recovery after nonsurgical root canal treatment in adults with teeth diagnosed with symptomatic apical…
- Conditions
- Symptomatic Apical Periodontitis, Postoperative Pain, Mechanical Allodynia
- Trial name
- NCT07886723
- Testing
- Adjunctive Photobiomodulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Bacterial Viability of Necrotic Pulp With Asymptomatic Apical Periodontitis
Molecular Analysis of Intracanal Microbes After Chemomechanical Procedure and Root Canal Medication: A Randomized Controlled Trial
This study aimed to evaluate clinically the intracanal microbes at molecular level after using established root canal medicament Calcium hydroxide and potential root canal medicament Glycyrrhizin.and Decontamination Analysis of…
- Trial name
- NCT06291623
- Testing
- Glycyrrhizin
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Obesity, Periodontitis
Evaluation of the Dental Health Condition in Obesity Patients Before and After Bariatric Surgery
The aim of this study is to investigate whether there was an association between obesity and periodontitis, tendency to caries and periapical lesions.
- Conditions
- Obesity, Periodontitis, Caries, Periapical Lesion
- Trial name
- NCT00531154
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chronic Kidney Diseases, Periapical Lesions
Association of Apical Periodontitis With Chronic Kidney Disease
This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy…
- Trial name
- NCT05818657
- Testing
- levels of CKD markers, Oral health status, apical periodontitis, systemic inflammatory marker, Oral health status, apical periodontitis
- Where
- India
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Diseases
Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT
A total of 60 patients presenting with single-rooted teeth exhibiting symptomatic apical periodontitis were subjected to a randomized allocation into two groups of 30 each.
- Trial name
- NCT07598188
- Testing
- Saline 0.9% (1.5-2.5°C)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Islamabad Medical and Dental College
Pulpitis - Irreversible, Apical Periodontitis
Evaluation of Nano Bioactive Glass Combined With i-PRF Scaffold in Vital Pulp Treatments
With consideration of the previous studies regarding the properties of i-PRF, it will be used in combination with another bioactive material: (Nano-BAG) versus using of i-PRF only as a pulpotomy material with using a premixed…
- Trial name
- NCT05902936
- Testing
- Pulpotomy for mature permanent mandibular molars
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp and Periapical Tissue Disease, Patients With Pulp Necrosis and Apical Periodontitis
Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis
The goal of this observational study is to evaluate changes in interleukin 8 (IL-8) and interleukin 10 (IL-10) levels in gingival crevicular fluid (GCF) and periapical fluid during root canal treatment in patients with necrotic…
- Trial name
- NCT06713174
- Testing
- Assessment of Interleukin 8 and 10 Level Changes Before and During Root Canal Treatment for Necrotic Pulp with Apical Periodontitis
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Apical Periodontitis
Comparison of Sonic and Ultrasonic Activation on Healing of Apical Periodontitis
The goal of this clinical trial is to learn whether two different irrigation activation methods - passive ultrasonic irrigation (PUI) and sonic activation - help periapical healing in root canal treatments of single-rooted teeth…
- Trial name
- SONIC-ULTRA (NCT07249450)
- Testing
- Sonic Activation Irrigation, Passive Ultrasonic Irrigation (PUI), Conventional Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hilal Çuhadar Beşiroğlu
Acute Apical Periodontitis of Pulpal Origin
Assessment of Masseter Muscle With Ultrasonography
In teeth that remain decayed for a long time, the muscles in that area atrophy because the patient cannot use the decayed area much. As a result, muscle length and mass decrease.
- Trial name
- NCT06734559
- Testing
- Patients who have not antibiotic treatment for acute apical periodontitis in the last month and have not taken any anti-inflammatory medication in the past 24 hours., patients who have not acute apical periodontitis
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Harran University
Pulp Necrosis, Root Canal Infection
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection
This research study is being done to find out if a natural ingredient called frankincense can clean infected root canals as effectively as the standard cleaning solution currently used in dentistry.
- Conditions
- Pulp Necrosis, Root Canal Infection, Apical Periodontitis
- Trial name
- FSHRCD: RCT (NCT07823868)
- Testing
- Sodium hypochlorite 3%, Frankincense-based irrigant
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Dental College