Clinical trials: Perimenopausal Disorder
Arterial Stiffening, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss.
- Conditions
- Arterial Stiffening, Aging, Menopause
- Trial name
- SHAPE (NCT00608062)
- Testing
- GnRHant - Ganirelix acetate, Transdermal estradiol patch
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopausal and Other Perimenopausal Disorders
Mirena and Estrogen for Control of Perimenopause Symptoms and Ovulation Suppression
Hormonal treatment of perimenopausal women has frequently utilized oral contraceptive pills (OCPs). Because of their ability to suppress ovulation and establish cycle control, OCPs have become a popular option, and one that is…
- Trial name
- NCT01613131
- Testing
- Mirena, Estradiol
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Colorado, Denver
Perimenopausal Disorder, Stress, Emotional
The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood
Women in the menopause transition ('perimenopause') are exposed to extreme hormone variability, tend to experience a unique set of severe stressors (e.g., divorce, death of loved ones), and are also at substantially elevated risk…
- Trial name
- Changes (NCT03003949)
- Testing
- Estradiol Patch, 0.1 Mg/24 Hours Weekly Transdermal Film, Extended Release, Progesterone Capsule
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Metastatic Breast Cancer
Comparative Real World Tumor Response in Pre-menopausal Metastatic Breast Cancer Patients Treated With Palbociclib + Aromatase Inhibitor or Aromatase Inhibitor Alone
This study aims to assess real-world tumor response in pre/perimenopausal HR+/HER2- metastatic breast cancer (MBC) patients initiating palbociclib + aromatase inhibitor (AI) or AI alone as first-line therapy during the period on…
- Trial name
- NCT05012644
- Testing
- Palbociclib + aromatase inhibitor, Aromatase inhibitor
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- Pfizer
Perimenopausal Depression, Depression
Raloxifene and Rimostil for Perimenopause-Related Depression
The purpose of this study is to evaluate the effectiveness of the drugs raloxifene and rimostil in treating perimenopause-related depression.
- Trial name
- NCT00030147
- Testing
- Raloxifene, Rimostil, Transdermal Estradiol
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Mental Health (NIMH)
Cardiovascular Risk Factor, Health Behavior
Reducing Cardiovascular Disease Risk in Perimenopausal Latinas
The goal of this study is to pilot test a 12-week behavioral intervention among perimenopausal Latinas (age 40-55 years) that integrates evidence-based education with physical activity, stress management, and coping skills…
- Conditions
- Cardiovascular Risk Factor, Health Behavior, Physical Activity, Self Efficacy
- Trial name
- NCT04313751
- Testing
- Education, Physical Activity, and Stress Management Program, Wait-list
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Vasomotor Symptoms, Hot Flashes
HIRREM Hot Flashes Study
The purpose of this research study is to determine the effects of a technique called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM®), for women in any stage of menopause, who are experiencing…
- Conditions
- Vasomotor Symptoms, Hot Flashes, Menopause
- Trial name
- NCT03512002
- Testing
- HIRREM, Continued Current Care
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University Health Sciences
Perimenopausal Depression
Perimenopausal Effects of Estradiol on Reward Responsiveness
Using neuroimaging, the investigator will study the effects of estrogen on mood and brain function in perimenopausal women either with or without depression.
- Trial name
- PEERS (NCT02255175)
- Testing
- Estradiol, Progesterone
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Insulin Sensitivity, Cardiovascular Risk
Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women
Birth control pills are the most commonly used method of birth control. The purpose of this research study is to examine whether birth control pills change heart disease risk and how the body handles blood sugar when given to…
- Conditions
- Insulin Sensitivity, Cardiovascular Risk, Perimenopausal Disorder
- Trial name
- NCT01475513
- Testing
- Ortho Cyclen®
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Hot Flushes, Night Sweats
Progesterone for Perimenopausal Night Sweats
The purpose of this study is to test whether a oral micronized progesterone reduces the Vasomotor Symptom Score comprised of the number and severity of hot flushes and night sweats in perimenopausal women.
- Trial name
- NCT01464697
- Testing
- Oral micronized progesterone
- Where
- Canada
- Volunteers
- 249 people
- Sponsor
- University of British Columbia
Breast Cancer
Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Breast Cancer
To compare the combination of Ribociclib plus goserelin acetate with hormonal therapy versus combination chemotherapy in premenopausal or perimenopausal patients with advanced or metastatic breast cancer
- Trial name
- RIGHT Choice (NCT03839823)
- Testing
- Docetaxel / Capecitabine, Capecitabine / Vinorelbine, Paclitaxel / Gemcitabine
- Where
- 50 sites in Egypt, India and 11 more
- Volunteers
- 222 people
- Sponsor
- Novartis Pharmaceuticals
Perimenopausal Disorder, Depression
Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"
Using neuroimaging, the investigator will study the effects of estrogen on mood and brain function in perimenopausal women with depression.
- Trial name
- Duavee (NCT03740009)
- Testing
- Bazedoxifene/Conjugated Estrogen
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder, Menopause
A Neurosteroid Intervention for Menopausal and Perimenopausal Depression
HYPOTHESIS: Pregnenolone administration will be associated with greater reduction in depressive symptom severity than placebo in women with current mMDD.
- Conditions
- Major Depressive Disorder, Menopause, Perimenopause
- Trial name
- NCT03505905
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Texas Southwestern Medical Center