Clinical trials: Periodic Breathing
Altitude Hypoxia
Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on sleep disordered breathing in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536507
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Normoxia, Hypoxia
Intrinsic Periodic Pattern of Breathing
We made a fortuitous observation of periodic breathing in a healthy subject coming to our outpatient mountain medicine consultation at Avicenne hospital in Bobigny (France).
- Conditions
- Normoxia, Hypoxia, Hyperoxia, Hypercapnia
- Trial name
- PERHYP1 (NCT02201875)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Association pour la Recherche en Physiologie de l'Environnement
Environmental Sleep Disorder, Cheyne-Stokes Respiration
Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude
One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration.
- Conditions
- Environmental Sleep Disorder, Cheyne-Stokes Respiration, Altitude Sickness
- Trial name
- PerOxySleep (NCT01465971)
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Goethe University
CHEYNE Stokes Respiration
Baclofen and Hypoxia-induced Periodic Ventilation
Periodic ventilation that includes CHEYNE Stokes ventilation is a pathological pattern characterized by alternating periods of hyperpneas and apnea-hypopneas.
- Trial name
- PERIODIBAC (NCT01095679)
- Testing
- Baclofen
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High-altitude Sleep Disturbance
Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude
More than 70% of visitors to high altitude suffer poor sleep. The present study seeks to answer the question: Which medication is associated with better sleep at high altitude: temazepam or acetazolamide? The investigators…
- Trial name
- NCT01519544
- Testing
- Temazepam, Acetazolamide
- Where
- Nepal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Sleep-Disordered Breathing
HighCycle Study: Effect of High Altitude on Sleep Disordered Breathing in Women Related to Their Menstrual Cycle Phase
Prospective cohort study investigating the menstrual cycle phase (MCP) dependent sleep disordered breathing (SDB) in women travelling to 3600 m.
- Trial name
- NCT06498544
- Testing
- Exposure to 3600 m
- Where
- Kyrgyzstan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy Men
Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects
This study investigates the effect of altitude exposure on sleep, breathing and psychomotor performance in healthy subjects.
- Trial name
- NCT01130948
- Testing
- altitude exposure
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Zurich
OSA, Proteinuria
The Association Between Sleep Duration and Sleep Disorders and Proteinuria in Children
The presence of protein in urine is a common laboratory finding in children. Although proteinuria is usually benign, it can be a marker of a serious underlying renal disease or systemic disorder.
- Conditions
- OSA, Proteinuria, Periodic Limb Movement Sleep Disorder
- Trial name
- NCT03933046
- Testing
- PSG
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Exertional Periodic Breathing
Chemoreflex Gain on Exercise
The purpose of this study is to assess chemoreflex gain on exercise.
- Trial name
- NCT01050179
- Testing
- carbon dioxide
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Sleep-Disordered Breathing
HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men
Randomized clinical trial evaluating the effect of acetazolamide on sleep disordered breathing in women compared to men travelling to 3600 m.
- Trial name
- NCT06498531
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep Disordered Breathing, Hypoxia
AT1R Blockade and Periodic Breathing During Sleep in Hypoxia
Sleep disordered breathing (SDB) is characterized by regular periods of no breathing (apnea) or low levels of breathing (hypopnea) and leads to repeated periods of low oxygenation, termed intermittent hypoxia that causes…
- Conditions
- Sleep Disordered Breathing, Hypoxia, Respiration; Sleep Disorder, Chemoreceptor Apnea
- Trial name
- NCT03335904
- Testing
- Hyperoxic Hypercapnic Ventilatory Response Test, Hypoxic Hypercapnic Ventilatory Response Test, Repeated Hypoxic Apneas
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Periodic Breathing, Heart Failure
The Cyclocapnic Method for Measurement of Chemosensitivity
We aim to test our method for measuring chemosensitivity (the ventilatory response to a change in carbon dioxide), which uses sinusoidal carbon dioxide stimuli.
- Trial name
- NCT01049256
- Testing
- carbon dioxide
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Altitude, Sleep Apnea, Central
Effects of Naltrexone on Nocturnal Breathing Patterns at Altitude
Sleep at altitude is often poor. The purpose of this study is to evaluate the effects of a single dose of the opioid antagonist, naltrexone, on sleep quality and periodic breathing after rapid ascent to ~3800m altitude.
- Trial name
- NCT05037032
- Testing
- Naltrexone Pill
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System