Clinical trials: Periodic Limb Movement Disorder
Healthy Subjects, Restless Legs Syndrome
Infra-slow Oscillations During Sleep
In this study the investigators plan to systematically characterise infra-slow EEG oscillations during sleep, explore their relationship to the microstructure of sleep, and investigate its role in the physiology and…
- Conditions
- Healthy Subjects, Restless Legs Syndrome, Periodic Limb Movements During Sleep
- Trial name
- SleepD-ISO (NCT02532608)
- Testing
- Acute sleep deprivation
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Stephany Fulda
Epilepsy Generalized Idiopathic Not Intractable
Periodic Limb Movement and Genetic Generalized Epilepsy
The study aimed to study the correlation between periodic limb movement occurring during sleep and the different parameters of genetic generalized epilepsy
- Trial name
- Epilepsy (NCT03587506)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Polysomnography, Sleep Apnea Syndromes
Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep Database
The primary purpose of the proposed study is to validate our previously developed predictive model for adults with obstructive sleep apnea using (i) clinical data from multiple large academic centers, (ii) a longer follow-up…
- Conditions
- Polysomnography, Sleep Apnea Syndromes, Risk Factors, Prognosis
- Trial name
- NCT03834792
- Testing
- No intervention but exposure
- Where
- Canada
- Volunteers
- 5,155 people
- Sponsor
- Ottawa Hospital Research Institute
Restless Legs Syndrome (RLS)
Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome
Several studies report association between restless legs syndrome (RLS), HTA and cardiovascular diseases . The mechanisms involved in this relationship remained unknown, but several evidences favor the role of periodic limb…
- Trial name
- NCT01823770
- Testing
- Rotigotine
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
ADHD, Iron-deficiency
Impact of Iron Supplementation Treatment on Brain Iron Concentrations
The goal of the present study is to provide novel data to evaluate brain iron concentration as a mediator of the association between iron supplementation treatment and improvement in symptoms of ADHD and RLS in children…
- Conditions
- ADHD, Iron-deficiency, Restless Legs Syndrome, Periodic Limb Movement Sleep Disorder
- Trial name
- NCT04144790
- Testing
- ferrous sulfate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Ischemic Stroke, Cerebral Infarct
Consequences of Post Stroke Polysomnographic Abnormalities on Functionnal Recovery and Survival After an Ischemic Stroke
Ischemic stroke is a major public health issue, likely to cause functional disability. It is well known that sleep has an impact on brain plasticity, and after an ischemic stroke, studies have shown subjective sleep quality…
- Conditions
- Ischemic Stroke, Cerebral Infarct, Sleep Apnea, Periodic Limb Movement Disorder
- Trial name
- PSG-AVC (NCT04816136)
- Testing
- Sleep recording (already done)
- Where
- France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Montpellier
Periodic Limb Movement Disorder, Cerebral Small Vessel Diseases
Periodic Limb Movement Syndrome in Patients With Cerebral Small Vessel Disease.
Patients from 60 to 75 years old diagnosed with cerebral small vessel disease with no history of symptomatic stroke, brain tumor, traumatic brain injury, seizures and neurodegenerative or mental disorder will undergo overnight…
- Conditions
- Periodic Limb Movement Disorder, Cerebral Small Vessel Diseases, Cognitive Dysfunction
- Trial name
- NCT04569643
- Testing
- Actigraphy, Cardiorespiratory monitoring, Neuroimaging
- Where
- Russia
- Volunteers
- 76 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Restless Legs Syndrome
Butrans for Treatment of Restless Legs Syndrome
The primary objective of the study is to determine whether Butrans Transdermal System (BTDS) reduces RLS symptom severity in patients with moderate to severe idiopathic RLS who are naïve to opiate treatment.
- Trial name
- Butrans (NCT02138357)
- Testing
- buprenorphine transdermal delivery system (BTDS)
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Spinal Cord Injuries, Periodic Limb Movement Disorder
Periodic Leg Movements' Diagnosis in Spinal Cord Injury: Actigraphy as an Alternative for Polysomnography?
Periodic Limb Movements during Sleep (PLMs) are episodes of repetitive, stereotypical, hallux or foot movements. They could induce sleep disturbance, fatigue, daytime sleepiness and impaired quality of life but also increased…
- Trial name
- ACTI-MPJ-BM (NCT04618978)
- Testing
- PSG and actigraphy recording
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
OSA, Proteinuria
The Association Between Sleep Duration and Sleep Disorders and Proteinuria in Children
The presence of protein in urine is a common laboratory finding in children. Although proteinuria is usually benign, it can be a marker of a serious underlying renal disease or systemic disorder.
- Conditions
- OSA, Proteinuria, Periodic Limb Movement Sleep Disorder
- Trial name
- NCT03933046
- Testing
- PSG
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sleep Disorder, Restless Legs Syndrome
Oral Iron Frequency for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder
The purpose of this research study is to see if the level of serum ferritin differs based on how often oral iron (in the form of ferrous sulfate) is given to children with restless leg syndrome/periodic limb movement disorder.
- Conditions
- Sleep Disorder, Restless Legs Syndrome, Periodic Limb Movement Sleep Disorder, Iron-deficiency
- Trial name
- NCT04610827
- Testing
- Ferrous sulfate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
The Aim of the Study Was to Screen Prevalence of Periodic Limb Movements Among Chronic Kidney Disease Patients
Periodic Limb Movements Among Dialysis and Non-dialysis Chronic Kidney Disease Patients
Periodic leg movement disorder is defined as periodic episodes of repetitive limb movements during sleep that mainly occur in the lower limb, including the hips, knees and toes and sometimes affects the upper limb.
- Trial name
- NCT05153616
- Testing
- Polysomnography
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Periodic Leg Movements, Excessive, Sleep-Related
Effect of Acute Exercise on Sleep Patterns in Patients With PLMS, Using a Wearable Device, Compared With a Control Group ( SONEX )
The effects of chronic exercise on health promotion, improvement of quality of life, and reduction of the risk of developing chronic diseases such as obesity, diabetes mellitus, cardiovascular diseases, depression, and cancer are…
- Trial name
- SONEX (NCT07382206)
- Testing
- cardiopulmonary exercise test (CPET), Cardiopulmonary Exercise Test (CPET) - Twice
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Restless Legs Syndrome
Ropinirole Tablets In Young Patients With Restless Legs Syndrome
This is a two-period dose rising study of Ropinirole Immediate Release in adolescent patients with restless legs syndrome (RLS) in order to determine the starting dose for the ropinirole titration regimen for this age group.
- Trial name
- NCT00140712
- Testing
- Ropinirole Immediate Release
- Where
- 9 sites in United States, Belgium and 1 more
- Volunteers
- 9 people
- Sponsor
- GlaxoSmithKline
Neurodevelopmental Disorders, Pediatric Sleep Apnea
Ambulatory Polysomnography in Neurodiverse Children: Feasibility, Quality, and Satisfaction
Laboratory polysomnography is the gold standard for objective sleep measurement. With hospital waiting times becoming increasingly long, outpatient polysomnography seems a good solution.
- Conditions
- Neurodevelopmental Disorders, Pediatric Sleep Apnea, Periodic Leg Movements, Excessive, Sleep-Related, Polysomnography
- Trial name
- NCT06966973
- Testing
- Polysomnograpy
- Where
- France
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- UPNOS
Restless Legs Syndrome
A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo
Proof of concept, double-blind, randomized, placebo-controlled trial with d-methadone proposed for the first time for use in the treatment of patients diagnosed with primary, moderate to very severe Restless Legs Syndrome (RLS).
- Trial name
- Glu-REST (NCT04145674)
- Testing
- D-methadone
- Where
- 4 sites in Italy, Switzerland
- Volunteers
- 50 people
- Sponsor
- Mauro Manconi
Restless Legs Syndrome (RLS), Restless Legs Syndrome
12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome
The purpose of this study is to assess the efficacy and safety of ropinirole CR-RLS in the treatment of patients with Restless Legs Syndrome and associated sleep disturbance and period limb movements during sleep.
- Trial name
- (CR-RLS) (NCT00373542)
- Testing
- ropinirole CR-RLS
- Where
- 45 sites in United States
- Volunteers
- 39 people
- Sponsor
- GlaxoSmithKline
Sleep Apnea Syndromes, Cardiovascular Diseases
The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes
Emerging evidence suggests that sleep-related disturbances such as sleep-disordered breathing (e.g. sleep apnea), sleep fragmentation, abnormal sleep architecture, and periodic limb movements (PLMs) are closely linked with…
- Conditions
- Sleep Apnea Syndromes, Cardiovascular Diseases, Sleep Initiation and Maintenance Disorders, Nocturnal Myoclonus Syndrome
- Trial name
- NCT03383354
- Testing
- Sleep-related disturbances (exposure)
- Where
- Canada
- Volunteers
- 5,000 people
- Sponsor
- Sunnybrook Health Sciences Centre