Clinical trials: Periodontal Diseases Inflammation
Post-Dental Gingival Pain, Gingival Swelling
Efficacy and Safety of HA35 Gel for Post-Dental Gingival Pain and Swelling
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of 10% high-concentration 35 kDa hyaluronan (HA35) gel delivered via gel-soaked cotton balls in patients with gingival pain…
- Conditions
- Post-Dental Gingival Pain, Gingival Swelling, Postoperative Oral Pain, Dental Procedure-Related Discomfort
- Trial name
- HA35 (NCT07584655)
- Testing
- 10% High-Concentration 35 kDa Hyaluronan (HA35) Oral Topical Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
COVID-19, Microbial Colonization
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease
Determining whether in the mouth there are differences between the participant groups in the nature and activity of mucosal innate immunity, in immune responses to SARS-COV2 antigens, or in the oral microbiome
- Conditions
- COVID-19, Microbial Colonization, Oral Disease, Periodontal Diseases
- Trial name
- MIMSA (NCT05212766)
- Testing
- COVID infection, COVID vaccination, Oral examination
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- King's College London
Dental Implantation, Peri-implant Mucositis
Periodontal Effects of Orthodontic Mini-Screws
Orthodontic mini-screws (TADs) are commonly used to provide temporary anchorage and prevent unwanted tooth movement during orthodontic treatment.
- Conditions
- Dental Implantation, Peri-implant Mucositis, Orthodontic Anchorage Procedures, Gingival Inflammation and Bleeding
- Trial name
- NCT07052747
- Testing
- Clinical periodontal assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Dr. Mehmet Selim Yildiz
Gingivitis
Efficacy of an Amine and Zinc Lactate - Containing Mouthrinse in the Home-based Treatment of Plaque-induced Gingivitis in Adolescents.
The goal of this clinical trial is to evaluate if the adjunctive use of an amine and zinc lactate - containing mouthrinse may give significant benefits in the home-based treatment of plaque-induced gingivitis in adolescents.
- Trial name
- SPA (NCT06671106)
- Testing
- toothbrushing, flossing, Toothpaste Product
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi di Ferrara
Periodontal Diseases, Gingivitis
Randomized Trial of a Gum Health Formulation
The purpose of this study is to evaluate the safety and efficacy of a newly formulated foaming gel product on gingivitis and/or moderate periodontitis when used with or without the GLO Science accelerating device (GLO Device)…
- Conditions
- Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
- Trial name
- NCT03196648
- Testing
- Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Glo Science, Inc.
Gingivitis
Functional Chewing Gum in Reduction of Gingival Inflammation
The aim of this prospective randomized 3-month double-blinded single center study is to determine whether a chewing gum device with food additive chitosan, will aid in reducing gingival inflammation by supplementing traditional…
- Trial name
- NCT03237624
- Testing
- Functional Chitosan Chewing Gum, Control Chewing Gum, Oral hygiene measures
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Maryland, Baltimore
Periodontal Diseases, Inflammation
Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression
Ribonucleic acids (RNA) are molecules that transfer genetic information from the nucleus to the cytoplasm for protein translation.
- Trial name
- NCT07142070
- Testing
- Saliva, serum sampling, oral isotretinoin
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medipol University
Apical Periodontitis, Caries
Effect of Lifestyle on Caries and Apical Periodontitis
This study aimed to link lifestyle factors (Mediterranean diet adherence, stress, sleep quality, physical activity) to caries and apical periodontitis in 149 university-based individuals.
- Conditions
- Apical Periodontitis, Caries, Lifestyle, Inflammation
- Trial name
- NCT06072742
- Where
- Italy
- Volunteers
- 149 people
- Sponsor
- University of Siena
Gingivitis, Periodontal Inflammation
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions.
- Conditions
- Gingivitis, Periodontal Inflammation, Orthodontic Appliance Complication
- Trial name
- NCT04606186
- Testing
- Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Periodontal Diseases
Enamel Matrix Derivatives on Systemic Inflammation After Periodontal Therapy
The aim of this study is to compare periodontal treatment with or without the adjunct of an enamel matrix derivative in terms of acute-phase responses in healthy patients.
- Trial name
- PERIOEMD-2 (NCT03544931)
- Testing
- Root Instrumentation, EMD Application
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Pisa
Plaque, Gingivitis
Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study
The objective of this randomized, single-center, examiner-blind, controlled, parallel group, six-month clinical study is to compare the antiplaque/antigingivitis potential of a no-alcohol essential oil containing mouthrinse and…
- Conditions
- Plaque, Gingivitis, Gum Inflammation, Bleeding
- Trial name
- NCT02980497
- Testing
- Listerine Zero Mouthwash (without alcohol), Listerine Antiseptic Mouthwash (with alcohol)
- Where
- Brazil
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
TMJ, Apical Periodontitis
Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning
The aim of the present study is to show that the use of 0.55T MRI combined with a "dental" coil produces images of sufficient diagnostic value to assess areas of interest in dentistry, and to compare MR images to traditional…
- Conditions
- TMJ, Apical Periodontitis, Periodontal Inflammation, Retained Tooth
- Trial name
- NCT05439330
- Testing
- MRI of teeth and surrounding structures
- Where
- Denmark
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gingival Inflammation
Comparison Between the Effect of Triclosan Toothpaste and Chlorhexidine Mouthwash on Gingival Health in a Group of Fixed Orthodontic Patients: A Randomized Controlled Clinical Trial
Study Protocol Introduction Title of the research study Comparison Between the effect of Triclosan Toothpaste and chlorhexidine Mouthwash on Gingival Health in Fixed Orthodontic Patients :A randomization controlled clinical…
- Trial name
- NCT07814898
- Testing
- Triclosan 0.3% toothpaste, sodium fluoride 0.24% toothpaste, Chlorhexidine 0.2% mouthwash
- Where
- Yemen
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Science and Technology, Yemen
Chronic Kidney Disease
Oral and Dental Health Status in Patients Suffering From Chronic Kidney Disease
A large panel of oral and dental diseases exist in patients suffering from chronic kidney disease (CKD) in end-stage renal disease: it concerns teeth, peridontium, alveolar bone and saliva and it has been already described in the…
- Trial name
- NEPHRODENT (NCT02114281)
- Testing
- Care, Not care
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Bordeaux
Obesity, Periodontitis
Periodontal Inflammation and Epigenetics in Obese Individuals
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis.
- Trial name
- NCT07610902
- Testing
- Non-surgical periodontal therapy will be administered
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Gingivitis, Probiotics
Effects of Probiotic Ayran on Gingivitis
Objectives: This study investigates the effects of daily consumption of probiotic ayran drink on gingival inflammation and the development of experimental gingivitis.
- Conditions
- Gingivitis, Probiotics, Inflamed Gums
- Trial name
- NCT06437925
- Testing
- probiotic ayran drink
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Periodontal Diseases, Periodontal Pocket
Comparison of Gingival Flap Procedure Using Conventional Surgical Loupes vs. Videoscope for Visualization
This study is being performed to compare different methods of visualization during routine gum surgery. The gum surgery is standard of care.
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontitis, Periodontal Inflammation
- Trial name
- NCT05932017
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Periodontitis (Stage 3), Periodontitis Stage IV
Characterization of Small Intestinal Bacterial Overgrowth and Intestinal Barrier-Related Biomarkers in Patients With Severe Periodontitis: A Pilot Prospective Longitudinal Observational Cohort Study
Periodontitis is a chronic inflammatory disease characterized by dysbiotic subgingival biofilms, inflammation, and progressive destruction of the tooth-supporting tissues.
- Conditions
- Periodontitis (Stage 3), Periodontitis Stage IV, SIBO
- Trial name
- MIRA (NCT07907224)
- Where
- Romania
- Volunteers
- 20 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Periodontitis
Impact of SRP on Bone Resorption and Systemic Inflammatory Markers in Postmenopausal Women With Periodontitis
This study is designed to determine the effect of treating postmenopausal women and using non-surgical techniques on biomarkers of systemic inflammation (IL-6 ) and systemic bone resorption (C-terminal collagen cross-links, CTX).
- Trial name
- NCT04261491
- Testing
- scaling and root planing
- Where
- 2 sites in India
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Oral Dysbiosis
Effects of a Composition on the Oral Microbiome, pH, Nitrite/Nitrate Ratio, Elastases and Inflammation in Oral Dysbiosis
Dysbiosis is a condition in which the normal function of an ecological net is altered. In dysbiosis a state of inflammation, a loss of hydration, a change in pH, a loss of the barrier function are all allies of key pathogens that…
- Trial name
- NCT05463484
- Testing
- Test composition Saliactive® (olive product, betaine and xylitol), Control
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Mucosa Innovations, S.L.