Clinical trials: Periodontal Diseases Inflammation
Dental Plaque, Patient Reported Outcome
The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes
The goal of this clinical trial is to to evaluate the antiplaque and antigingivitis effect of pure green tea mouthwash compared to placebo and essential oils mouthwashes in healthy patients.
- Conditions
- Dental Plaque, Patient Reported Outcome, Gingival Inflammation and Bleeding, Gingival Inflammation
- Trial name
- NCT07364565
- Testing
- Pure Green Tea Mouthwash, Listerine Total Care Mouthwash, Listerine Green Tea Mouthwash
- Where
- Jordan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Periodontitis, Adult, Inflammation Gum
Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients.
This study will determine if cannabidiol (CBD) has any effect on local inflammation in periodontal maintenance patients. Many successful therapies exist for the active, untreated periodontal patient.
- Trial name
- NCT05646459
- Testing
- cannabidiol, floss, proxabrush
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Gingivitis
Effect of Mouthrinsing on Inflammation of the Gums.
The purpose of this study is to determine whether rinsing with an amine fluoride/stannous flouride mouthrinse in addition to daily tooth brushing is more effective than tooth brushing alone.
- Trial name
- NCT01317446
- Testing
- amine fluoride/stannous fluoride
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Technische Universität Dresden
Oxidative Stress, Inflammation
Inflammatory Stress and Periodontal Tissue Destruction
Metabolic syndrome and periodontitis are diseases that lower the quality of life and their incidence rates are increasing. Since both of these diseases are associated with systemic inflammation and insulin resistance, they may be…
- Trial name
- NCT06092853
- Testing
- Gingival crevicular fluid (GCF) and serum samples
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Cleft Lip and Palate, Periodontal Pocket
Periodontal Changes Following Mid Maxillary Distraction
To evaluate the health status of the periodontium and dentition at the distraction osteogenesis site in CLP subjects using mid maxillary distraction (MMD).
- Conditions
- Cleft Lip and Palate, Periodontal Pocket, Attachment Loss, Periodontal
- Trial name
- NCT03686761
- Testing
- A Involvement with the osteotomy site of the surgery
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Edentulous Alveolar Ridge, Peri-Implantitis
Soft Tissue Response to Different Restorative Materials Used in Implant Dentistry
The goal of this clinical trial is to learn how different materials used in dental implants affect the surrounding gum tissue in adults who need dental implants.
- Conditions
- Edentulous Alveolar Ridge, Peri-Implantitis, Peri-implant Mucositis, Prosthetic Infection
- Trial name
- NCT06554041
- Testing
- Dental Crown with Titanium-Abutment, Dental Crown with PEEK (Polyetheretherketone)-Abutment, Dental Crown with Zirconia-Abutment
- Where
- Lithuania
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Inflammation, Periodontal Diseases
Mechanisms of Acute Inflammation Following Periodontal Treatment
Periodontitis (gum disease) is a chronic inflammatory disease linked to a imbalance of oral microbiome. The most usual treatment involves removal of sub and supra-gingival plaque and calculus otherwise known as Non-surgical…
- Trial name
- MANTRA (NCT05178563)
- Testing
- IPT+PDT
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University College, London
Sensitive Gum, Gum Inflammation
Usage Test on a New Cosmetic Product: Mouthwash
The goal of this clinical trial is to learn if a new mouthwash can help soothing oral mucosa in adult patients with sensitive gums.
- Trial name
- NCT06808711
- Testing
- Buccocéan mouthwash, Marketed mouthwash
- Where
- France
- Volunteers
- 50 people
- Sponsor
- YSLab
Pediatric Obesity, Periodontal Disease
Dental and Periodontal Health in Obese Adolescents: Clinical, Biochemical, and Microbiological Evaluation
This study aims to investigate whether obesity affects oral and gum health in children and adolescents. A total of 75 children aged 8 to 13 years participated, including both obese and non-obese individuals.
- Conditions
- Pediatric Obesity, Periodontal Disease, Inflammation Biomarkers, Dental Plaque
- Trial name
- PERIOBESITY (NCT07086027)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Marmara University
Peri-implantitis, Dental Implant Complications
Analysis of the Factors Influencing the Occurrence of Peri-implant Inflammation in Patients With Oral Implant Repair and Study on the Maintenance Effect of Subgingival Sandblasting
Abstract Objective The purpose of this study was to analyze the factors affecting the occurrence of peri-implant inflammation in patients with oral implant repair, and to explore the effect of subgingival sandblasting technology…
- Conditions
- Peri-implantitis, Dental Implant Complications, Periodontal Inflammation, Gingival Diseases
- Trial name
- NCT06998160
- Testing
- glycine subgingival sandblasting group and erythritol subgingival sandblasting group, control group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Hui Xie
Gingivitis, Periodontal Disease
Rapid Point-of-Care Salivary Diagnostic for Periodontal Health
The purpose of this study is to learn if a chair-side testing device will accurately measure levels of a salivary biomarker and thus indicate if a patient has periodontal health, gingivitis or periodontal disease.
- Trial name
- NCT02403297
- Testing
- Quik Check PD
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Innovative Diagnostics Inc
Dysbiosis, Inflammation Gum
Microbiome Alterations With Xylitol (MAX) in Pregnancy
The purpose of this study is to understand if chewing xylitol-gum initiated before 20 weeks of pregnancy and continued until delivery affects the bacteria that are found in the oral and vaginal cavities, signs of inflammation…
- Conditions
- Dysbiosis, Inflammation Gum, Placenta-mediated Pregnancy Complications, Microbioata
- Trial name
- MAX (NCT06329596)
- Testing
- Xylitol gum, Sorbitol gum
- Where
- Malawi
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Peri-Implantitis and Peri-implant Mucositis, Peri-Implantitis and Systemic Inflammation
Longitudinal Evaluation of Regenerative Treatment of Peri-implantitis Assited by Er,Cr:YSGG Laser: up to 10 Years Follow-up
Peri-implantitis is a pathological condition characterized by the inflammation of peri-implant connective tissues and progressive alveolar bone loss.
- Trial name
- Laser (NCT07104760)
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Guarulhos
Gingival Inflammation, Dental Plaque Accumulation
Evaluation of the Anti-plaque Effect of a Bioflavonoid-based Antiseptic Mouthwash
This study evaluates the antiplaque efficacy of a bioflavonoid-based mouthwash compared to a positive control (0.12% chlorhexidine mouthwash).
- Trial name
- NCT07824388
- Testing
- Bioflavonoid mouthwash, Chlorhexidine 0.12% mouthwash
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Gingival Inflammation, Oral Bacterial Infection
Gingival Inflammatory Response,Bacterial Adhesion and Patient Satisfaction of Ceramo-metallic vs Zirconia Crowns
Ceramo metallic restoration has proved high success rate over past years as considered to be the gold standard while Monolithic zirconia as fixed dental prostheses have gained attention because of their good fracture strength…
- Trial name
- CairoU (NCT04077606)
- Testing
- ceramo-metallic crown prepartion, full anatomical monolithic zirconia crown
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Calculus, Gingivitis and Periodontal Diseases
Bio-Descaling Toothpaste for Dental Calculus Reduction
Dental calculus is a calcified mineralized plaque composed primarily of calcium phosphate salts covered by an unmineralized bacterial biofilm layer.
- Conditions
- Dental Calculus, Gingivitis and Periodontal Diseases, Periodontal Diseases
- Trial name
- AntiCal (NCT07689071)
- Testing
- Bio-Descaling Powder (BDP) Toothpaste
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Periodontal Disease
Epigenetics, DNA Methylation Patterns and Periodontal Disease
The overall goal of this research is (1) to identify changes in gene expression and DNA methylation status in subjects who exhibit advanced chronic periodontal inflammation and (2) to identify microRNAs (miRNAs) and the…
- Trial name
- SZU (NCT01399034)
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Mild Gingival Recession, Periodontal Inflammation
Efficacy and Safety of HA35 Gel for Mild Gingival Recession and Periodontal Inflammation
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of topical 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with mild gingival recession and chronic…
- Conditions
- Mild Gingival Recession, Periodontal Inflammation, Chronic Gingival Pain, Gingival Redness and Swelling
- Trial name
- HA35-PERI (NCT07577258)
- Testing
- 10% High-Concentration 35 kDa Hyaluronan (HA35) Gingival Topical Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
Periodontal Diseases
Clinical Evaluation of a Mouthwash Containing Malva Sylvestris Extract.
Background: For centuries, plants (and / or their products) were the only resource available for the prevention and treatment of many diseases.
- Trial name
- NCT05138484
- Testing
- experimental group 10% mouthwash of M. sylvestris extract
- Where
- Chile
- Volunteers
- 54 people
- Sponsor
- Aravena, Pedro, DDS, PhD