Clinical trials: Periodontal Diseases Inflammation
Periodontal Diseases, Inflammation Gum
Evaluation of Oral Condition and the Effect of Dental Treatment on Physical Parameters of Athletes
It is essential that athletes have perfect general health. Oral health plays an important role in this healthy framework necessary so that the results that must be achieved by athletes are not influenced.
- Conditions
- Periodontal Diseases, Inflammation Gum, Caries,Dental
- Trial name
- NCT04251858
- Testing
- Dental Scaling, Oral hygiene instruction
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidade Metropolitana de Santos
Peri-implantitis
Peri-implantitis Management: Surgical and Maintenance Outcomes
The goal of this clinical trial is to learn how two standard surgical treatments for peri-implantitis affect inflammation around dental implants.
- Trial name
- NCT07550127
- Testing
- Resective surgery with implantoplasty, Resective surgery with mechanical debridement
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Pittsburgh
Gingivitis
AI Gum Health Evaluation with Smartphone
Background The most common dental diseases are tooth decay (caries) and gum disease (gingivitis and periodontitis). Obviously, these diseases are caused by dental plaque (bacterial biofilm).
- Trial name
- NCT05685355
- Testing
- Standardized intraoral photography
- Where
- Hong Kong
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Periodontal Disease, Periodontitis
Investigation of the Relationship Between Periodontitis and Alzheimer's Disease in Terms of Blood Parameters
The aim of this study was to analyse the possible relationship between periodontal inflammation and Alzheimer's disease and to investigate the role of blood parameters in this relationship.
- Conditions
- Periodontal Disease, Periodontitis, Periodontal Inflammation, Biomarkers / Blood
- Trial name
- NCT07069244
- Testing
- Complete Blood Count Test, Periodontal examinations, Clinical Dementia Rating scale
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uskudar University
Metabolic Syndrome (MetS), Periodontitis
Metabolic Syndrome Associated Diet
The goal of this observational study is to examine the relationship between metabolic syndrome (MetS) and periodontitis, and to evaluate the role of the Dietary Inflammatory Index (DII) in this association.
- Conditions
- Metabolic Syndrome (MetS), Periodontitis, Diet, Food and Nutrition
- Trial name
- NCT07462104
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Inflammation, Periodontal Diseases
Mechanisms of Acute Inflammation Following Periodontal Treatment
Periodontitis (gum disease) is a chronic inflammatory disease linked to a imbalance of oral microbiome. The most usual treatment involves removal of sub and supra-gingival plaque and calculus otherwise known as Non-surgical…
- Trial name
- MANTRA (NCT05178563)
- Testing
- IPT+PDT
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University College, London
Heart Transplant, Periodontitis
Effect of Non-Surgical Periodontal Therapy on Inflammation in Heart Transplant Recipients
Heart transplant recipients frequently exhibit chronic low-grade systemic inflammation, which can contribute to allograft dysfunction and cardiovascular complications.
- Conditions
- Heart Transplant, Periodontitis, Gingivitis, Systemic Inflammation
- Trial name
- NCT07791927
- Testing
- Full-mouth periodontal debridement
- Volunteers
- 20 people
- Sponsor
- Baskent University
Periodontal Diseases, Periodontitis
Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial
The aim of this study is to assess whether and how a mouthwash containing an ingredient that reduces inflammation in combination with a recently developed treatment is more effective at improving advanced gum disease.
- Trial name
- AIRTIM (NCT07203872)
- Testing
- IsoDent Paro Strong (Isodent Ltd. Valtakatu 4 D, 96100 Rovaniemi, Finland) mouthwash
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Gingival Inflammation, Dental Plaque
Bacteria in Dental Plaque and Atheroma Plaque
Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood.
- Conditions
- Gingival Inflammation, Dental Plaque, Atheroma Plaque, Oral Bacteria
- Trial name
- NCT07100574
- Testing
- atheroma plaque, dental plaque
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Saglik Bilimleri University
Gingivitis and Periodontal Diseases
Evaluation of Toothbrush Bristles
The goal of this randomized clinical trial is to investigate two different types of toothbrush bristles. The main questions it aims to answer are the effects of two different bristle types on: how much plaque is on the teeth how…
- Trial name
- NCT07306026
- Testing
- Toothbrush with tapered bristles, Toothbrush with end-rounded bristles
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Gingivitis, Orthodontic Appliance Complication
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions.
- Trial name
- NCT04598633
- Testing
- Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Chronic Periodontitis
CBD Effects on Periodontal Health of Patients With Chronic Periodontitis
The suppression of chronic periodontitis after application of dental gel and toothpaste containing cannabidiol (CBD) will be evaluated.
- Trial name
- Stoma-CBD (NCT05498012)
- Testing
- Cannabidiol dental gel, Cannabidiol toothpaste
- Where
- Czechia
- Volunteers
- 90 people
- Sponsor
- Palacky University
Periodontal Diseases, Inflammation
Kynurenine Pathway in Parkinson's Disease
Parkinson's disease is a slowly progressing disease that affects the motor and non-motor functions of an individual. Periodontitis is an inflammatory chronic disease resulting in the destruction of tooth supporting structures.
- Trial name
- NCT07272564
- Testing
- Saliva and serum sampling, Saliva, serum and GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Gingivitis
Evaluation of 3 Oral Self-care Regimens on Clinical Signs of Inflammation and Plaque
To compare three different oral hygiene regimens on changes in gum tissue appearance, gum bleeding, and plaque scores.
- Trial name
- NCT05766995
- Testing
- Waterpik Water Flosser, Oral-B Water Flosser, Waxed Dental Floss
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Water Pik, Inc.
Obesity, Peri-implant Inflammation
The Effect of Obesity on Oral Peri-implant Health - A Cross-Sectional Study
In recent years, greater emphasis has been placed on the link between oral and systemic health. Obesity, a growing medical problem worldwide, has been associated with multiple chronic inflammatory diseases such as diabetes…
- Conditions
- Obesity, Peri-implant Inflammation, Peri-implantitis
- Trial name
- NCT01878071
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Bacteremia, Periodontal Diseases
Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis
Approximately 40,000 Swedes suffer from sepsiseach year, about 20% die. Biomarkers that are sensitive to current or previous bacteremia are needed in the treatment of sepsis.
- Conditions
- Bacteremia, Periodontal Diseases, Sepsis, Heart Diseases
- Trial name
- NCT04565691
- Testing
- Non-surgical periodontal treatment
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Malmö University
Gingival Inflammation and Bleeding, Dental Plaque
Clinical Efficacy Evaluation of Three Dentifrices
Clinical study to evaluate and compare the efficacy of two baking soda containing dentifrices, containing 20% and 35% baking soda, to a non-baking soda dentifrice for their ability to reduce gingivitis and plaque following…
- Trial name
- NCT03988374
- Testing
- Dentifrices
- Where
- Canada
- Volunteers
- 319 people
- Sponsor
- Church & Dwight Company, Inc.
Gingivitis, Periodontitis
Bacteremia in Periodontal Patients
Bacteremia represents the presence of live germs in the blood stream. Patients with gum disease show damaged tissues and seem to be more susceptible to bacteremia.
- Trial name
- NCT02215473
- Testing
- Chlorhexidine gluconate mouth rinse, Periodontal instrumentation
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Taubate
Gingivitis, Circadian Rhythm Disruption
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption
This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and…
- Conditions
- Gingivitis, Circadian Rhythm Disruption, Periodontal Inflammation, Circadian Rhythm Sleep Disorder, Shift Work Type
- Trial name
- Nursma-CIRC-HG (NCT07592052)
- Testing
- Standard Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Inonu University