Clinical trials: Periodontal Intrabony Defects
Intrabony Periodontal Defect
Regenerative Combined Therapy With Enamel Matrix Derivative and Biphasic Calcium Phosphate Graft
Background: The use of Enamel Matrix Derivative (EMD) when dealing with non-contained defects may be limited, as EMD does not maintain a space itself.
- Trial name
- NCT02828423
- Testing
- EMD, BC
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Periodontitis, Intrabony Periodontal Defect
MIST Versus M-MIST for the Treatment of Intrabony Defects
This is a 12-month longitudinal, double-blind, parallel-design randomized controlled clinical trial involving surgical therapeutic intervention (Phase 4).
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontitis, Chronic
- Trial name
- NCT06058923
- Testing
- M-MIST, MIST
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontitis
Autologous Micrografts From the Palatal Mucosa for Periodontal Regeneration
Some research studies have demonstrated that autologous micrografts made out of different oral tissues may enhance tissue regeneration.
- Trial name
- NCT06105125
- Testing
- Rigenera + bone substitute, Bone substitute alone
- Where
- Italy
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Periodontitis
Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis
Among the root conditioning materials is the Ethylenediaminetetraacetic acid (EDTA). EDTA exposes the collagen fibers on dentin surfaces and also enhances early cell colonization.
- Trial name
- NCT04044417
- Testing
- currettage, curcumin simvastatin paste, EDTA root conditioning
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Periodontal Regeneration Using Vitamin A and PRF Compared to PRF Alone Treating Intra-bony Defects
Will the addition of vitamin A (Retinol) to PRF add more periodontal regenerative value in the treatment of intra-bony defects compared to PRF alone, clinically?
- Trial name
- NCT05285293
- Testing
- Platelet Rich Fibrin (PRF), Platelet Rich Fibrin (PRF) and Retinol
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases
Minimally Invasive Surgical Technique in Management of Intrabony Defects
In the fast-growing era of contemporary periodontology, the understanding of biological concepts in wound healing together with the evolution of the flap design and biomaterials applied in periodontal regeneration allowed for…
- Trial name
- NCT06591416
- Testing
- minimally invasive surgical technique, minimally invasive surgical technique with granulation tissue preservation
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Intrabony Periodontal Defect
Simplified Papilla Preservation Flap(SPPF) and Enamel Matrix Derivative(EMD) With or Without Connective Tissue(CTG) Wall for the Treatment of Non Contained Infrabony Defects. A Randomized Controlled Clinical Trail
Research is to compare and evaluate the clinical and radiographic outcomes of the enamel matrix derivative with or without connective tissue wall graft for noncontained infrabony defects using simplified papilla preservation…
- Trial name
- NCT06530199
- Testing
- Enamel matrix derivative
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontitis
Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects
ABSTRACT: Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which releases various growth factors that promote tissue regeneration.
- Trial name
- NCT02283554
- Testing
- open flap debridement (OFD), Platelet rich fibrin (PRF), Metformin
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Regeneration
Amnion Chorion Membrane Combined With Allograft Bone Putty for the Management of Intrabony Defects
The ultimate goal for periodontal management is to obtain true periodontal regeneration. Periodontal regeneration implies that CAL gain is achieved through the formation of new cementum and new inserted periodontal ligaments…
- Trial name
- NCT05922527
- Testing
- Combined regenerative technique, Open flap debridement
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Evaluation of Volume Stable Collagen Matrix in the Regenerative Outcome of Periodontal Intrabony Defects
Periodontal intrabony defect is a specific osseous defect with definite morphology. Numerous therapeutic modalities for restoring such defects have been investigated.
- Trial name
- NCT05569473
- Testing
- TEST GROUP: VCMX + OFD, CONTROL GROUP : OFD ONLY
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Intrabony Defect
Regenerative Potential of Cultured Gingival Fibroblast- Mesenchymal Stem Cells in Treatment of Periodontitis
clinical trial was conducted to evaluate regenerative potentials of cultured gingival fibroblasts and GMSCs carried in beta tri calcium phosphate scaffold into intrabony periodontal defects in human by clinical and radiographic…
- Trial name
- NCT03638154
- Testing
- GF+GMSCs carried on β TCP, β TCP bone substitute only
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Regeneration of Intrabony Defects With Nano Hydroxyapatite Graft, and Periosteum as Barrier Membrane Under Magnification
The prospective study is a interventional study to evaluate and compare the effectiveness of periosteal pedicle as grafting technique and egg shell derived nano hydroxyapatite as regenerative graft material for regeneration of…
- Trial name
- NCT04195295
- Testing
- Regeneration of Intrabony Defects with Nano Hydroxyapatite Graft, Derived from Egg Shell along with Periosteum as Barrier Membrane, Regeneration of intrabony defects using Egg shell derived nano hydroxyapatite (EnHA) as regenerative graft material, Open flap debridement procedure in intrabony defects.
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Intrabony Defects, Stage III Grade B Periodontitis
Sub-junctional Pinhole Technique
Pinhole Regenerative Therapy (PRT) following minimally invasive non-surgical periodontal therapy (MINST) in the treatment of intrabony defects associated with Stage III Grade B periodontitis.
- Trial name
- PRT (NCT07763223)
- Testing
- Sub-junctional Pinhole Technique (S-PHT)
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Chronic Periodontitis
Locally Delivered Metformin & Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone.
- Trial name
- NCT03204058
- Testing
- Rosuvastatin, Metformin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Minimally-invasive Non-surgical Therapy of Intrabony Defects
This investigation aims to assess the clinical and radiographic outcomes of intrabony defects treated with minimally-invasive non-surgical therapy.
- Trial name
- NCT03741374
- Testing
- Minimally-invasive non-surgical therapy (MINST)
- Where
- 9 sites in Australia, Italy and 2 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Periodontal Diseases
The Use of Leucocyte Platelet Rich Fibrin (L- PRF) Covered Perforated Guided Tissue Membrane for Treatment of Periodontal Intrabony Defects
This study is the first to investigate the effect of leucocyte platelet rich fibrin (L-PRF) combined with perforated membrane in order to treat infrabony defects and assess their combined effect in clinical attachment level gain…
- Trial name
- NCT04576468
- Testing
- Open flap debridement, perforated membrane, leucocyte - platelet rich fibrin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Advanced Platelet Rich Fibrin in Periodontal Angular Defects
The aim of this study is to clinically and radiographically evaluate the efficacy of advanced platelet-rich fibrin (A-PRF) when used with biphasic alloplast in the management of intrabony defects in patients with moderate to…
- Trial name
- NCT03433066
- Testing
- Advanced platelet-rich fibrin mixed with biphasic alloplast, Biphasic alloplast mixed with saline
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Chronic Periodontitis
Comparison of Rosuvastatin With Atorvastatin in Chronic Periodontitis
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical and radiographic efficacy of two local drug delivery systems containing 1.2% RSV gel and 1.2% ATV gel in…
- Trial name
- NCT02600520
- Testing
- SRP with RSV gel LDD, SRP with ATV gel LDD
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Diseases
Influence of Local Doxycycline on the Outcomes of Periodontal Regeneration
In this double-blinded randomized clinical trial, patients presenting periodontal intrabony defects requiring regenerative surgery and showing BoP will be included.
- Trial name
- NCT05878353
- Testing
- Decontamination of the pocket with local doxycycline, Decontamination of the pocket with mechanical instrumentation
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Periodontal Bone Loss
Erythropoietin Gel as an Adjunct to Xenograft in the Surgical Management of Intrabony Periodontal Defects
The aim of the study is to evaluate the use of erythropoietin gel as an adjunct to xenograft in the surgical management of intrabony periodontal defects.
- Trial name
- NCT05360511
- Testing
- particulate xenograft + erythropoietin gel., particulate xenograft
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ain Shams University