Clinical trials: Periodontal Intrabony Defects
Periodontitis
Periodontal Osseous Wall Piezosplitting and EDTA Root Surface Etching
This study was designed to investigate the use of minimally invasive Piezo knife to harvest vascularized interceptal bone pedicle in treating intrabony defects.
- Trial name
- NCT03670979
- Testing
- bone swaging
- Volunteers
- 16 people
- Sponsor
- Al-Azhar University
Intrabony Periodontal Defects
Minimally Invasive Non-Surgical Therapy Versus Single Flap Approach in Management of Periodontal Intrabony Defects
This study aims to evaluate the clinical and 3D radiographic effects of minimally invasive non-surgical periodontal therapy (MINST) compared to single flap approach (SFA) in management of intrabony defects in stage III or IV…
- Trial name
- NCT07822659
- Testing
- minimally invasive non-surgical therapy, minimally invasive periodontal surgery
- Volunteers
- 40 people
- Sponsor
- Cairo University
Periodontitis, Aggressive
Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis
The treatment of intrabony defects in patients with aggressive periodontitis remains a challenging procedure and novel therapeutic strategies are sought.
- Trial name
- NCT03340012
- Testing
- GTR + radiation-sterilize allogenic bone graft, GTR + xenogenic graft
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Periodontitis
Minimally-invasive Non-surgical and Surgical Periodontitis Treatment
To compare the efficacy of a modified minimally-invasive non-surgical periodontal therapy (MINST) approach with a surgical approach (M-MIST) in determining bone and clinical attachment changes in intrabony defects
- Trial name
- NCT03797807
- Testing
- MINST, MIST, GTI subgroup (Geometrical/Thermal Imaging)
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Periodontitis
Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects
Over the last 30 years, the prevalence of periodontitis (PE) has increased substantially, including among younger populations, highlighting the need to improve the management of this condition as a chronic disease and to develop…
- Trial name
- NCT07522684
- Testing
- Polynucleotide and hyaluronic acid-based gel, Control, Xenogeneic bone graft
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- University of Sao Paulo
Periodontal Diseases, Bone Resorption
Bioactive Glass and Platelet Rich Fibrin in Intrabony Defects
Background: Platelet-rich fibrin (PRF) and bioactive glass putty has been shown to be effective in promoting reduction in probing depth, gain in clinical attachment, and defect fill in intrabony periodontal defects.
- Trial name
- NCT02982681
- Testing
- Platelet rich fibrin, Bioactive Glass
- Volunteers
- 10 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Chronic Periodontitis
Evaluation of Nano-crystalline Hydroxyapatite Silica Gel in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of Nano-crystalline hydroxyapatite silica gel in comparison with open flap debridement for management of periodontal intrabony defects.
- Trial name
- NCT02507596
- Testing
- Nano-crystalline hydroxyapatite silica gel, open flap debridement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Efficacy of PRF With M-MIST in the Treatment of Intrabony Defects
This study evaluates the efficacy of M-MIST with or without PRF in the treatment of intrabony defects.Taking into consideration of advantages of PRF and M-MIST it was hypothesised that this combination (PRF+M-MIST) would be more…
- Trial name
- NCT03169920
- Testing
- Modified-Minimally Invasive Surgical Technique + PRF, Modified-Minimally Invasive Surgical Technique
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Disease, Intrabony Periodontal Defects
A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration in Adult Periodontitis Patients
The goal of this clinical trial is to learn if a novel peptide-rich hydrogel works to achieve periodontal regeneration in adults. It will also learn about the safety of the hydrogel.
- Trial name
- PERIHEAL (NCT07581613)
- Testing
- Hydrogel
- Where
- 2 sites in Norway, Spain
- Volunteers
- 40 people
- Sponsor
- Siddharth Shanbhag
Controlled Type 2 Diabetic Patients With Periodontitis
Clinical and Radiographic Evaluation of Subgingival 1% Metformin Gel Versus 0.05% Zoledronate Gel as an Adjunct to MINST of Intrabony Defects in Controlled Type 2 DM
The present randomized placebo-controlled trial aims to evaluate and compare the clinical and radiographic efficacy of subgingivally delivered 0.05% zoledronate gel and 1% metformin gel as adjuncts to minimally invasive…
- Trial name
- NCT07753317
- Testing
- All participants will receive MINST
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases
The Use of Leucocyte Platelet Rich Fibrin (L- PRF) Covered Perforated Guided Tissue Membrane for Treatment of Periodontal Intrabony Defects
This study is the first to investigate the effect of leucocyte platelet rich fibrin (L-PRF) combined with perforated membrane in order to treat infrabony defects and assess their combined effect in clinical attachment level gain…
- Trial name
- NCT04576468
- Testing
- Open flap debridement, perforated membrane, leucocyte - platelet rich fibrin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Periodontitis, Bone Loss
Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis…
- Conditions
- Chronic Periodontitis, Bone Loss, Intrabony Periodontal Defect
- Trial name
- NCT04767243
- Testing
- open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin), open flap debridement and filled with Bioactive glass (Perioglas®), open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Periodontal Bone Loss, Periodontal Attachment Loss
Platelet-rich Fibrin and Autogenous Bone vs Enamel Matrix Derivative and Autogenous Bone in Intrabony Defects
Currently, the most positive documented outcomes of periodontal regenerative therapy (PRT) in intrabony defects (IBDs) have been achieved with a combination of bone grafts ( BGs) and a regeneration material like membranes in…
- Trial name
- NCT03510780
- Testing
- Periodontal surgery with Enamel Matrix Derivative, Periodontal surgery with Platlet Rich fibrin
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontal Diseases
Autologous Platelet Concentrate (APC) in Intrabony Defects
The aim of this 12-month clinical study is to treat patients affected by gum disease (periodontitis) by a minor gum surgery that aims to reduce the depth of the gum pockets.
- Trial name
- NCT04254861
- Testing
- Simplified Papilla Preservation Flap (SPPF) and PRGF ENDORET (PRGF ENDORET®-KMU16), Simplified Papilla Preservation Flap (SPPF) and GTR
- Where
- United Kingdom
- Volunteers
- 74 people
- Sponsor
- Queen Mary University of London
Vascular Endothelial Growth Factor Overexpression, Membrane Alteration
Perforated Barrier Membranes Maintain Physiologic Gingival Crevicular Fluid Growth Factor Levels
Membrane modifecation: Guided tissue membrane perforations may serve as a more biologic scaffold that could allow for the free passage of biologic mediators from the periosteum and overlying gingival connective tissue into the…
- Trial name
- NCT02168322
- Testing
- collagen membrane
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Aggressive Periodontitis
Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis
Approaches and objectives related to the treatment of patients with aggressive periodontitis are not markedly different compared patients with the chronic form.
- Trial name
- NCT03025204
- Testing
- Enamel Matrix Proteins, Open Flap Debridement
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Campinas, Brazil
Intrabony Periodontal Defect
Advanced Platelet Rich Fibrin in Periodontal Angular Defects
The aim of this study is to clinically and radiographically evaluate the efficacy of advanced platelet-rich fibrin (A-PRF) when used with biphasic alloplast in the management of intrabony defects in patients with moderate to…
- Trial name
- NCT03433066
- Testing
- Advanced platelet-rich fibrin mixed with biphasic alloplast, Biphasic alloplast mixed with saline
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Periodontal Intrabony Defects, Bone Regeneration
Comparison of Effects of Eggshell Derived Nano Hydroxyapatite and Hydroxyapatite in Management of Periodontal Intrabony Defects
The aim of the study is to evaluate osseous regenerative efficacy of eggshell derived nanohydroxyapatite in comparison with hydroxyapatite The test group includes patients with intrabony defects where flap surgery will be…
- Trial name
- NCT07160101
- Testing
- Eggshell derived nano hydroxyapatite, Hydroxyapatite
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Dr R Viswa Chandra
Periodontal Pocket
Different Autologous Products in The Treatment of Intrabony Defects
The aim of this study is to evaluate and compare the efficiencies of platelet-rich fibrin (PRF), concentrated growth factor (CGF) and autologous bone graft (ABG) in the treatment of patients who have intrabony pockets clinically…
- Trial name
- NCT05941312
- Testing
- autologous products
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Periodontitis
RhBMP-2 in Intrabony Defects - A Randomized Controlled Trial
This study evaluated the regenerative potential of rhBMP-2 gel in intrabony defects when compared to sticky bone (control).
- Trial name
- NCT04368650
- Testing
- BMP-2, PRF
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences