Clinical trials: Periodontal Pocket
Periodontal Diseases, Periodontal Pocket
Effectiveness of SRP+ Lipo-curcumin Gel for the Treatment of Stage III Periodontitis.
The aim of the present study is to clinically and radiographically compare the effectivness of Scaling and Root Plannig (SRP) in association with lipo-curcumin gel (LC) respect SRP+ lipo-gel (L), SRP+ discharged (D) gel and SRP…
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontal Attachment Loss
- Trial name
- NCT06624241
- Testing
- Lipo-Curcumin gel + SRP, Lipo gel + SRP, Discharged Gel + SRP
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontitis, Periodontal Diseases
Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice
Periodontitis is a bacterial inflammatory disease and antibiotic use is being empirically used as part of its treatment. However, a clinical practice guideline on periodontal treatment adjuncts published in 2015 identified weak…
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Pocket
- Trial name
- PAAS (NCT06131021)
- Testing
- Amoxicillin, Metronidazole
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Periodontitis, Adult, Periodontal Diseases
Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial
Background: To profile gingival crevicular fluid (GCF) β-Catenin, 8-OHdG, and total antioxidants capacity (TAC) in periodontitis patients during healing of periodontal pockets following non-surgical periodontal therapy…
- Trial name
- NCT07596667
- Testing
- scaling and root planing
- Volunteers
- 21 people
- Sponsor
- Zeyad Nazar
Chronic Periodontitis
Clinical Trial of PeriZone PerioPatch in Subjects With Chronic Periodontitis
The purpose of this study is to determine if a topical, adhesive patch (PeriZone PerioPatch) applied to the gums after a deep tooth cleaning (scaling and root planing) reduces the signs of advanced gum disease (chronic…
- Trial name
- NCT01808703
- Testing
- PeriZone PerioPatch, Scaling and root planing alone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- MIS Implant Technologies, Ltd
Periodontal Diseases
Adjunctive Local Sodium Hypochlorite Gel in Non Surgical Periodontal Debridement
The aim of this study was to assess the efficacy of minimally invasive nonsurgical debridement (MINSD) of periodontal pockets with or without local amino acid buffered sodium hypochlorite (NaOCl) gel application after 6 months…
- Trial name
- NCT04399187
- Testing
- Sodium hypochlorite gel application
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Messina
Periodontal Diseases, Periodontal Pocket
Clinical Efficacy of Saffron Mouth Rinse in Periodontitis Patients With Renal Disease
The commensal oral bacteria are responsible for the initiation and propagation of the disease through the process of dysbiosis, or microbial imbalance.
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontal Inflammation
- Trial name
- NCT06235021
- Testing
- Saffron, chlorhexidine mouthwash
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- British University In Egypt
Periodontitis
Comparison of Adjunctive Chemomechanical Therapy With Standard Care in Patients With Periodontitis
The goal of the clinical trial is to compare adjunctive chemomechanical therapy with standard care regarding root planning in patients with periodontitis.
- Trial name
- NCT05757921
- Testing
- Perisolv (A), Standard (B)
- Volunteers
- 38 people
- Sponsor
- Kristianstad University
Attachment Loss, Periodontal, Teeth, Impacted
Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar Extraction
Background: Prevention of periodontal defects after the extraction of lower third molars remains a challenge. Various methods have been proposed in the literature, but there are no studies which evaluated the effectiveness of…
- Trial name
- NCT04314726
- Testing
- Amelogenin
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Periodontal Diseases, Periodontal Attachment Loss
Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects
The aim of the present study is to clinically and radiographically compare the efficacy of recombinant human platelet-derived growth factor (rhPDGF), Leukocyte-Platelet Rich Fibrin (L-PRF) and Enamel Matrix Derivatives (EMD) in…
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Pocket, Periodontal, Intrabony Periodontal Defect
- Trial name
- NCT05858411
- Testing
- SRP+rhPDGF, SRP+L-PRF, MINST alone
- Where
- Albania
- Volunteers
- 88 people
- Sponsor
- G. d'Annunzio University
Periodontal Diseases, Periodontal Pocket
Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study
The goal of this split-mouth clinical trial is to evaluate the effects of Manuka honey applied into periodontal pockets after initial periodontal therapy (NSPT) in the treatment of stage 3 periodontitis.
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontal Bone Loss, Periodontal Attachment Loss
- Trial name
- NCT05631600
- Testing
- Manuka honey
- Where
- Croatia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Periodontitis, Bleeding Gum
Effect of a Hydrogen-Peroxide and Hyaluronic-Acid Mouthwash (BMG0703) in the Treatment of Periodontitis
Assessment of the efficacy of BMG0703 in the treatment of periodontitis and control of supragingival plaque, compared to Chlorhexidine and a placebo product
- Conditions
- Periodontitis, Bleeding Gum, Pocket, Periodontal
- Trial name
- NCT04446533
- Testing
- Hydrogen Peroxide and Hyaluronic acid filming formulation, Chlorhexidine 0.2%
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Periodontal Pocket
The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic
The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal…
- Trial name
- NCT06669026
- Testing
- vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel, vitamin D3 gel (regular non-nanoparticle form), only mechanical debridement
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periodontal Pocket
The Efficacy of Salvia Officinalis Gel in the Treatment of Periodontitis CLINICAL TRIAL
From each participant, two sites of periodontal pockets ( ≥ 5 mm ) were selected and randomly allocated to either the test site (treated with scaling and RSD with S.
- Trial name
- clinical (NCT06900517)
- Testing
- Salvia officinalis Gel
- Volunteers
- 23 people
- Sponsor
- University of Baghdad
Chronic Periodontitis (Disorder), Periodontitis
i-PRF & Root Surface Biomodification
This study is designed to evaluate a new method to improve healing in patients with gum disease (periodontitis). A total of 42 adults with gum pockets deeper than 5 millimeters will take part.
- Trial name
- iPRF-Perio (NCT07207668)
- Testing
- Open Flap Debridement (OFD), 24% EDTA Root Conditioning, Injectable Platelet-Rich Fibrin (i-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Halil Ata BIÇAKÇIOGLU
Prediabetic State, Type 2 Diabetes Mellitus With Oral Complications
Undiagnosed Diabetes in a Dental Setting
In an ongoing study new dental patients are screened to determine their risk of having undiagnosed pre-diabetes or diabetes based on risk factors readily known by the patient and signs of gum disease.
- Conditions
- Prediabetic State, Type 2 Diabetes Mellitus With Oral Complications, Periodontal Pocket, Tooth Loss
- Trial name
- NCT01711385
- Testing
- Enhanced intervention
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Columbia University
Periodontitis, Chronic Periodontitis (Disorder)
Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Therapy in Stage II Periodontitis
Gum disease (periodontitis) affects millions of people worldwide and can lead to tooth loss if untreated. The standard treatment is a deep cleaning procedure called non-surgical periodontal therapy (NSPT), where a dentist removes…
- Trial name
- aPDT-NSPT (NCT07609888)
- Testing
- Non-Surgical Periodontal Therapy (NSPT), Antimicrobial Photodynamic Therapy (aPDT) with Indocyanine Green and 810 nm Diode Laser
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Gulf Medical University
Periodontology, Periodontal Disease
Evaluation of Hyaluronic Acid and Chlorhexidine Gel as an Adjunct to Minimally Invasive Non-surgical Therapy in the Treatment of Stage III and IV Periodontitis
Stage III and IV periodontitis are advanced forms of periodontal disease characterized by significant attachment loss, deep periodontal pockets, and progressive destruction of supporting periodontal tissues.
- Conditions
- Periodontology, Periodontal Disease, Periodontal Diseases, Periodontitis (Stage 3)
- Trial name
- NCT07731113
- Testing
- MINST + CHX+HA gel, MINST
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Chronic Periodontitis
RELATIONSHIP BETWEEN INITIAL PROBING DEPTH AND CHANGES IN CLINICAL PARAMETERS FOLLOWING NON-SURGICAL PERIODONTAL TREATMENT IN CHRONIC PERIODONTITIS PATIENTS
Aim: The aim of this study was to evaluate the relationship between initial probing depth (IPD) and changes in clinical parameters following non-surgical periodontal treatment (NPT) in chronic periodontitis patients.
- Trial name
- NCT02861326
- Testing
- Gracey Curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis
Evaluation of Prognostic Potentials of Gingival Crevicular Fluid E-cadherin and Total Antioxidant Capacity
Ability to anticipate the outcomes of periodontal therapy at baseline visit is crucial to outline and customize a treatment plan with predictable outcomes and cost-effectiveness.
- Trial name
- NCT05994885
- Testing
- Root surface debridement
- Where
- Iraq
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ali A Abdulkareem