Clinical trials: Periodontitis, Adult, open to volunteers
Periodontitis, Adult, Furcation Defects
A Chitosan Brush and Enamel Matrix Derivative for Non-surgical Treatment of Furcations
Patients diagnosed with stage III or IV periodontitis who exhibit mandibular first or second molars with Class II, Subclass A, or B buccal and/or lingual mandibular furcation defects (horizontal probing depth of ≥ 3 mm ) will be…
- Conditions
- Periodontitis, Adult, Furcation Defects, Furcation of Root of Tooth, Periodontitis Complex
- Trial name
- NCT06684769
- Testing
- Emdogain® FL, Labrida BioClean®
- Where
- Latvia
- Volunteers
- 40 people
- Sponsor
- Riga Stradins University
Periodontitis, Adult, Periodontitis
Evaluation of Masticatory Performance in Patients With Periodontitis
The objective of this observational study is to assess the correlation between the severity of periodontal involvement and masticatory performance in patients with periodontitis.
- Conditions
- Periodontitis, Adult, Periodontitis, Oral Disease
- Trial name
- PAROCHEW (NCT07665489)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis, Adult, Periodontitis
Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis.
Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth and may negatively affect patients' oral health-related quality of life.
- Conditions
- Periodontitis, Adult, Periodontitis, Oral Disease, Quality of Life
- Trial name
- PAROQoL (NCT07868042)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis, Adult, Prediabetes / Type 2 Diabetes
HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced Periodontitis
This study will evaluate whether HbA1c screening can be performed in dental care to detect elevated blood glucose in patients with advanced periodontitis and support referral to primary care.
- Trial name
- DENT-PC (NCT07688278)
- Testing
- Point-of-care HbA1c screening, Conditional standardized primary care referral
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Skane
Periodontitis, Adult, Periodontal Diseases
Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial
Background: To profile gingival crevicular fluid (GCF) β-Catenin, 8-OHdG, and total antioxidants capacity (TAC) in periodontitis patients during healing of periodontal pockets following non-surgical periodontal therapy…
- Trial name
- NCT07596667
- Testing
- scaling and root planing
- Volunteers
- 21 people
- Sponsor
- Zeyad Nazar
Edentulous Mouth, Periodontal Diseases
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in…
- Conditions
- Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
- Trial name
- NCT06149585
- Testing
- Microbial Sampling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Periodontitis, Chronic Periodontitis
Vector® System vs Mini-Five Curettes in Non-Surgical Periodontal Therapy
This randomized clinical trial aims to compare the clinical and radiographic outcomes of the Vector®️ ultrasonic system and mini-five curettes in non-surgical periodontal therapy.
- Trial name
- VECTOR-RCT (NCT07452640)
- Testing
- Vector® Ultrasonic System, Mini-Five Curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Hacettepe University
Dental Caries (Diagnosis), Dental Plaque (Diagnosis)
Assessment of Dental Pathologies Using Digital Tools
Digital technology is playing an increasingly important role in dentistry, because of its ability to support the practitioner and increase work efficiency.
- Conditions
- Dental Caries (Diagnosis), Dental Plaque (Diagnosis), Periodontitis
- Trial name
- RESTODATA-NUM (NCT07205588)
- Where
- 22 sites in France, Reunion
- Volunteers
- 350 people
- Sponsor
- Recherche Clinique en Odontologie (ReCOL)
Periodontitis
Electrolysed Saline Rinse as an Adjunct for Treatment of Chronic Periodontitis
The study will be conducted as a prospective, double-blind, parallel, randomized, placebo-controlled study at the Dental Clinic of University Medical Centre Ljubljana.
- Trial name
- EOSPERIO (NCT06692582)
- Testing
- Electrolysed saline rinse, Distilled water group, Chlorhexidine 0,12%
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University of Ljubljana
Oral Disease, Cardiovascular Diseases
Oral Health in Adults: Social Gradients and Correlation With Cardiovascular Health
Non-communicable diseases (NCDs) are rising in prevalence because of aging, unhealthy diet and sedentary lifestyle, and common NCDs are caries and periodontitis (here oral diseases) and cardiovascular disease (CVD).
- Conditions
- Oral Disease, Cardiovascular Diseases, Diabetes
- Trial name
- HUSK (NCT05758467)
- Where
- Norway
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Periodontitis, Adult
Full Mouth Ultrasonic Debridement Carried Out With Either Piezoelectric or Magnetostrictive Device
The treatment of periodontitis requires the removal of dental biofilm through both professional mechanical plaque removal and at-home oral hygiene practices.
- Trial name
- NCT06934291
- Testing
- Full-mouth ultrasonic debridement with piezoelectric device (EMS, mini piezon), Full-mouth ultrasonic debridement with magnetostrictive device (Cavitron Select, Dentsply)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University of Siena
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Asymptomatic Apical Periodontitis
Effect of Calcium-Based Bioceramic Sealer and Resin-Based Sealer on Postoperative Pain
This study aims to compare the effect of calcium-based bioceramic sealer and resin-based sealer on postoperative pain in adult patients with asymptomatic apical periodontitis undergoing root canal treatment.
- Trial name
- NCT07256691
- Testing
- Resin-based sealer obturation technique, Bioceramic sealer obturation
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Fatima Memorial Hospital
Allostatic Load, Periodontitis, Chronic
Impact of Periodontal Inflammation on Allostatic Load
Periodontitis is a prevalent global health issue that contributes to systemic inflammation and is closely linked to stress as a risk factor. Both conditions have been investigated for bidirectional relationship.
- Trial name
- NCT06978712
- Testing
- Sub-gingival instrumentation
- Where
- India
- Volunteers
- 112 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Dental Implantation, Missing Teeth
The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness
Scientists do research to answer important questions which might help change or improve the way we do things in the future. The investigators know that using Enamel Matrix Derivatives results in thicker gum tissues around teeth.
- Conditions
- Dental Implantation, Missing Teeth, Periodontitis, Adult, Mucositis
- Trial name
- NCT07053969
- Testing
- Enamel Matrix Derivative
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity, Oral Diseases
Obesity and Oral Diseases in Adult Patients
Overweight and obesity are among the major chronic disorders of the 21st century and one of the fastest growing health problems worldwide.
- Conditions
- Obesity, Oral Diseases, Periodontitis, Dental Caries
- Trial name
- ObOd (NCT04602572)
- Testing
- Lifestyle course., Bariatric surgery.
- Volunteers
- 400 people
- Sponsor
- University of Bergen
Chronic Periodontitis, Oral Cancer
The Link Between Periodontitis, Smoking and Oral Cancer
Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and…
- Trial name
- NCT04047212
- Testing
- biopsy for oral cancer, periodontal examination
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Periodontitis, Adult, Periodontitis (Stage 3)
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response.
- Conditions
- Periodontitis, Adult, Periodontitis (Stage 3), Periodontitis Stage IV
- Trial name
- PROPARO (NCT07443410)
- Testing
- Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT), Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®), Vitamin B12 drops (natural elements)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Stage II, Grade B Periodontitis, Chronic Periodontitis
Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis
This clinical trial is designed to evaluate two locally delivered gels, metformin and chlorhexidine, as adjunctive therapies to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis.
- Trial name
- MET-CHX Perio (NCT07215156)
- Testing
- Arm 1 Scaling and Root Planing (SRP), Arm 2 Metformin Gel 1% (locally delivered), Arm 3 Chlorhexidine Gel 0.2% (locally delivered)
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Periodontal Diseases
Non-surgical Treatment of Chronic Periodontitis With an Adjunctive Vitamin E and Coenzyme Q10 Supplementation
Non-surgical treatment of chronic periodontitis with vitamin E and coenzyme Q10 supplementation
- Trial name
- NCT06373848
- Testing
- Receive 30 mg of Coq10
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj