Clinical trials: Periodontitis
Intrabony Periodontal Defect
Clinical Evaluation of Injectable Alb-PRF in the Management of Intrabony Defect in Stage-III Periodontitis Patients
Clinical Evaluation of Injectable Albumin Platelet Rich Fibrin Versus Platelet Rich Fibrin in the Management of Intra-bony Defect in Stage-III Periodontitis Patients.
- Trial name
- NCT06297577
- Testing
- Albumin Platelet Rich Fibrin (Alb-PRF) combined with minimally invasive surgical technique (MIST), Minimally invasive surgical technique (MIST)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis
Effect of Use of Calcium Hydroxide and Metformin Intracanal Medicament After NSRCT
Goal of this randomized clinical trial is evaluate the effect of Calcium Hydroxide and Metformin Intracanal Medicament on periapical healing after NSRCT.
- Trial name
- NCT06766201
- Testing
- Metformin
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Dental Caries, Gingivitis
Antimicrobial Efficacy of Biogenic Gold Nano Particle From Pelargonium Graveolens Leaves Extract Mouthwash for Children
The study is randomized controlled trial ... The null hypothesis of the present study is that there is no antibacterial efficacy of gold nanoparticles of pelargonium graveolens mouthwash against Streptococcus mutans and Candida…
- Conditions
- Dental Caries, Gingivitis, Periodontitis
- Trial name
- GNPG (NCT05816512)
- Testing
- Gold Nano particle from Pelargonium Graveolens Mouthwash, Chlorhexidine gluconate mouthwash .
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ahmed Yousif Mahdi
Pulp Necroses, Apical Periodontitis
Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis
The purpose of the study is to evaluate the effect of Mesenchymal Stromal Cell (MSC) implantation on pulp and periapical regeneration of immature teeth with pulp necrosis and chronic apical periodontitis.
- Trial name
- MSC (NCT04545307)
- Testing
- Allogenic transplant of BM-MSC in a root canal from patients with immature apexes and pulpar necrosis and apical periodontitis
- Where
- Venezuela
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Universidad Central de Venezuela
Gingivitis, Periodontitis
Clinical Examination of Metal Free Interdental Brushes
The aim of the study was to evaluate the clinical efficacy (Eastman Interdental Bleeding Index, Quigley and Hein) of a novel metal-free interdentalbrush compared to a classig metal-core interdental brush.
- Trial name
- NCT01593540
- Testing
- metal-free interdental brush, metal-core interdental brush
- Where
- Germany
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Freiburg
Aggressive Periodontitis
Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1
The aim of this study is to estimate GCF MCP-1 levels of healthy and Aggressive periodontitis (AgP) subjects and to compare MCP-1 levels between Localized AgP (LAgP) and Generalized AgP (GAgP) to establish its predictive…
- Trial name
- MCP-1 (NCT02927704)
- Testing
- Gingival crevicular fluid (GCF) sample
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Chronic Periodontitis
Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
The objective of this study is to evaluate the anti-inflammatory and anti-infective properties of amniotic membrane (AM) when used for guided tissue regeneration (GTR) in periodontal bone defects.
- Trial name
- NCT02033226
- Testing
- Amniotic Membrane, Control group (Hydroxyapatite only)
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Periodontitis
Periodontitis and Inflammation: Study on Biological Samples
Periodontitis is a major public health problem because it is widespread in the adult population. It leads to the irreversible destruction of the anchoring tissues of the teeth, and represents a modifiable risk factor for systemic…
- Trial name
- CB-PARO2 (NCT06012019)
- Testing
- Biological sampling in Periodontitis Case, Biological sampling in Gingivitis Case, Biological sampling in Control Case
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Apical Periodontitis, Insulin Resistance
Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis.
Inflammation is a common factor of chronic periodontitis and diabetes. However, to date, there is no scientific evidence supporting a causal effect of the inflammation created by apical periodontitis on the onset of insulin…
- Conditions
- Apical Periodontitis, Insulin Resistance, PreDiabetes, Diabetes; Stable
- Trial name
- NCT04824209
- Where
- 2 sites in Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Periodontitis
Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets
This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD)…
- Trial name
- NCT02316652
- Testing
- Scaling and root planing, Scaling and root planing with solution
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Periodontal Diseases
Analysis of Gingival Crevicular Fluid
The purpose of this study was to investigate and compare GCF interleukin-1β (IL-1β), interleukin-10 (IL-10), interleukin-36γ (IL-36γ) levels in patients with healthy (H), gingivitis (G) and chronic periodontitis (CP) status.
- Trial name
- GCF (NCT05325905)
- Testing
- Gingival crevicular fluid sampling
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Periodontitis
Periodontitis Severity and Associated Factors Among Egyptian Males and Females
This cross-sectional study aims to evaluate and compare the severity of periodontitis between a group of Egyptian males and females.
- Trial name
- NCT07721337
- Testing
- Clinical Periodontal Examination and Questionnaire
- Where
- Egypt
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periodontal Bone Loss, Periodontal Pocket
Locally Injected Vit D as a Non-surgical Modality for Periodontal Regeneration of Infrabony Defects
vitamin D has great role in bone regenration and soft tissue health. in the past periodontal regeneration was performed using bone graft and barrier membrane
- Trial name
- NCT03716765
- Testing
- locally injected vitamin D
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post-operative Pain
Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment
Aim :to compare incidence of post-operative pain and apical healing after single-visit versus two-visit root canal treatment of teeth with necrotic pulp and apical periodontitis.
- Trial name
- NCT03120845
- Testing
- One visit RCT, Post operative pain in two-visits RCT
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Jorge Paredes Vieyra
Chronic Periodontitis
Dose Parameters for Photodynamic Therapy on Periodontal Disease
Due to the phenomenon of bacterial resistance, photodynamic therapy (PDT) has been studied as an alternative to the use of antibiotics on the periodontal treatment.
- Trial name
- NCT03262077
- Testing
- Methylene Blue, Methylene Blue Oral Product
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Chronic Periodontitis, Prehypertension
Impact of Periodontal Intervention on Vascular Dysfunction
The purpose of this study is to determine the effect of periodontal intervention on vascular dysfunction among Chinese prehypertensive adults with moderate to severe periodontal disease.
- Trial name
- NCT01917292
- Testing
- One-Stage Full-Mouth Disinfection, Periodontal care
- Where
- China
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Periodontal Diseases, Gingivitis
Asprosin, Adropin, Irisin Levels in Periodontitis
The recently discovered association of the hormones 'asprosin, adropin and irisin' with obesity and metabolic status, as well as the fact that periodontal diseases are affected by obesity and nutrition bilaterally, have led us to…
- Conditions
- Periodontal Diseases, Gingivitis, Obesity
- Trial name
- NCT06250764
- Testing
- Clinical periodontal measuremenets, ELISA test from gingival crevicular fluid (GCF)
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- AYSAN LEKTEMUR ALPAN
Periodontitis
GCF Levels of IL-1Beta, MIP-1 Alfa and G-CSF in Gingivitis and Stage I-II-III-IV Periodontitis Patients
Periodontal diseases are chronic diseases that occur as a result of a violation of the balance between microbial dental plaque and the host response.
- Trial name
- NCT04629313
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Uşak University
Periodontitis, Periodontal Diseases
Determination of Salivary Soluble Urokinase Plasminogen Activator Receptor (SuPAR), Hypoxia-inducible Factor-1 Alpha (HIF-1α), E-cadherin, Galectin 3, IL-4, IL-10 and TNF-α Levels in Individuals With Different Degrees of Periodontal Disease
The aim of this clinical study is; Comparatively comparing salivary Soluble Urokinase Plasminogen Activator Receptor (SuPAR), Hypoxia-inducible factor-1 alpha (HIF-1α), E-cadherin, galectin 3, IL-4, IL-10 and TNF-α levels in…
- Trial name
- NCT06430450
- Testing
- Clinical measurements and saliva samples collection
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Periodontitis
Air Polishing as an Adjunct in Non-surgical Periodontal Therapy
Periodontal disease is an infection that causes inflammation and destruction of the tooth supporting structures, and if untreated, will eventually lead to tooth loss.
- Trial name
- NCT04178291
- Testing
- Ultrasonic scaler and Gracey currettes, Air polishing with erythritol powder
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Malaya
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