Clinical trials: Periodontitis
Periodontitis, Normal Blood Pressure
Tongue Dysbiosis Effects on Arterial Pressure of Periodontitis Patients
Blood pressure control is crucial for individuals' wellbeing. However, many daily aspects such as diet could impair blood pressure control.
- Trial name
- TODY (NCT04027179)
- Testing
- 0.12% chlorhexidine digluconate mouthwash, Periodontal instrumentation
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Taubate
Chronic Periodontitis
Comparison of Alendronate With Atorvastatin in Chronic Periodontitis
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of two local drug delivery systems containing 1% ALN gel and 1.2% ATV gel in treatment of…
- Trial name
- NCT02455869
- Testing
- SRP and Atorvastatin, SRP and Alendronate
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Tobacco Use, Periodontitis
Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden
Smoking and dual using associated with poor periodontal health.
- Trial name
- NCT03918902
- Testing
- Qestinnaires
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Periodontitis, Treatment Adherence
I-Smads in Periodontitis
Recently, it has been stated that Smads play an active role in all conditions where transforming growth factor-beta (TGF-β) is involved, including periodontal inflammation.
- Trial name
- NCT04846166
- Testing
- Periodontally healthy group, Periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Periodontal Health, Periodontitis
Effect of Periodontal Treatment on Salivary and Serum Biomarkers in Periodontitis
The present study aimed to determine the effect of non-surgical periodontal treatment on serum and salivary SIRT-1, MMP-9, and T-SOD levels in periodontitis stage III grade B (P-III-B) and C (P-III-C) patients.
- Trial name
- NCT06255470
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis
Impact of Periodontal Treatment on NT-proBNP Levels
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence the management of Periodontitis, the aim of this study was to evaluates, at 6-months follow-up, the…
- Trial name
- NCT05174494
- Testing
- Evaluation of serum CRP and NT-proBNP
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Catania
Periodontal Diseases, Epigenetics
DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.
Periodontitis is related to host genetics, constitution of the dental biofilm and environmental factors such as smoking. DNA methylation is a mechanism of genetic expression that can inhibit or silence gene expression.
- Trial name
- NCT03371446
- Testing
- oral epithelial cells obtained by rinsing with 3% sucrose
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontal Disease, Periodontal Disease Stage 2
Probiotics And Ozonated Olive Oil To Maintain Oral Eubiosis In Stage I And II Periodontitis Patients
The goal of this clinical trial is to investigate the clinical benefits of the combined use of ozonized olive oil products (mouthwash and toothpaste) and probiotics on the health status of patients with Stage I and II…
- Trial name
- NCT06955546
- Testing
- Toothpaste Product, Mouthwash Product, Probiotic
- Where
- Italy
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Massimo Corsalini
Head and Neck Cancer, Chronic Periodontitis
Estimation of (suPAR) in Chronic Periodontitis With Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy Side Effect
- Trial name
- HNCs (NCT06529588)
- Testing
- Radiation
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Periapical Periodontitis
Evaluation of Three Irrigants, Sodium Hypochlorite, Chlorhexidine and Combination of CHX+H2O2 in Endodontic Treatment.
This study will evaluate the synergistic effect of CHX + H2O2 when used as an irrigant during biomechanical preparation.in root canal treatment on periapical healing and compared with Chlorhexidine( CHX) and Sodium Hypochlorite…
- Trial name
- NCT04373018
- Testing
- Sodium hypochlorite, Chlorhexidine, Chlorhexidine + Hydrogen peroxide
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Periodontitis, Generalized
Flapless Emdogain in the Treatment of Periodontal Residual Pockets
48 adult patients participated in a single-centre randomized clinical trial with split- mouth design. They had presented at re-evaluation after initial non-surgical periodontal therapy (steps 1 and 2 of periodontal therapy) for…
- Trial name
- NCT05823389
- Testing
- Re-instrumentation with flapless Emdogain application
- Where
- Palestinian Territories
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Arab American University (Palestine)
Dental Caries, Periodontitis
Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets
This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.
- Conditions
- Dental Caries, Periodontitis, Oral Microbiome, Bacterial Transmission
- Trial name
- NCT07674888
- Testing
- Professional Dental Plaque Disruption
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Root Canal Treatment, Irreversible Pulpitis With Apical Periodontitis
Effect of Probiotics, Double Antibiotic Paste, and Calcium Hydroxide on Postoperative Pain in Irreversible Pulpitis: A Randomized Trial
The goal of this clinical trial is to learn whether probiotics, double antibiotic paste (DAP), or calcium hydroxide paste help reduce postoperative pain after root canal treatment in adults with symptomatic irreversible pulpitis.
- Conditions
- Root Canal Treatment, Irreversible Pulpitis With Apical Periodontitis, Pulpitis - Irreversible, Post Operative Pain, Acute
- Trial name
- NCT07270159
- Testing
- Probiotic
- Where
- Pakistan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Periodontitis
Emdogain Minimally Invasive Surgical Technique
The aim of this controlled study is to assess the clinical outcomes and patient reported outcomes of using minimally invasive surgical procedure with Straumann Emdogain as an adjunct (test treatment) or without Straumann Emdogain…
- Trial name
- NCT02551770
- Testing
- Scaling and root planing, Scaling and root planing without Emdogain, Emdogain application
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
Endodontic Disease, Pulp Disease, Dental
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal…
- Conditions
- Endodontic Disease, Pulp Disease, Dental, Intracanal Medication
- Trial name
- NCT06207253
- Testing
- Diclofenac Sodium, Calcium hydroxide
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Chronic Periodontitis Wth Diabetes Mellitus
Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.
Statins are specific competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known for its hypolipidemic actions, possessing biologically significant anti-inflammatory and antioxidant properties…
- Trial name
- NCT03745300
- Testing
- ATORVASTATIN, SIMVASTATIN
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis
This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.
- Trial name
- NCT05759416
- Testing
- Melatonin2%gel
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Chronic Periodontitis
Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony Defects
A clinical and radiographic evaluation of 2 regenerative techniques, bioresorbable membrane and bone allograft for management of periodontal intrabony defects.
- Trial name
- NCT02679209
- Testing
- Demineralized bone matrix in putty form, Amnion chorion membrane
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intervention Studies, ASA Physical Status I
Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications: 1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite 2. Calcium Silicate 3.
- Conditions
- Intervention Studies, ASA Physical Status I, Intracanal Medication, Periapical Abscess
- Trial name
- RCT (NCT07641933)
- Testing
- Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontal Diseases
Addition of Dehydrated Human Amnion-Chorion Membrane During Scaling and Root Planing
Hypothesis: There will be an additional reduction of pocket depth and gain of clinical attachment when dehydrated human amnion-chorion membrane (dHACM) is placed into the periodontal disease defect after mechanical scaling and…
- Trial name
- NCT03836378
- Testing
- BioXclude™
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver