Clinical trials: Periodontitis
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers
The study proposes to assess the effect of multiple applications of antimicrobial Photodynamic Therapy (aPDT) as an adjunct to non-surgical periodontal treatment (nsPT) in smokers without use of antibiotics.
- Trial name
- NCT03039244
- Testing
- Photodynamic therapy, Control Group, Diode Laser
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Post-operative Pain, Retreatment
Evaluation of Postoperative Pain After Single Visit Retreatment of Symptomatic and Asymptomatic Teeth
Introduction: The aim of this study comparing the post operative pain after the retreatment of asymptomatic and symptomatic teeth that during single visit treatment with rotary and reciprocal nickel titanium files.
- Conditions
- Post-operative Pain, Retreatment, Symptomatic Periapical Periodontitis, Endodontic Disease
- Trial name
- Endodontics (NCT06357481)
- Testing
- Endodontic Retreatment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Aggressive Periodontitis
Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis
A total of 20 intra-bony defects in 10 LAP patients were randomly assigned into two groups 10 defects each in a split-mouth design. Group I treated by surgery plus Bio-Oss bone graft + collagen membrane (Control group).
- Trial name
- RCT (NCT05001919)
- Testing
- GTR, concentrated growth factor
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tanta University
Periodontitis
IL-32 Levels in Patients With Chronic Periodontitis
Interleukin-32 (IL-32) is a recently described cytokine that is a strong inducer of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α.
- Trial name
- NCT02632981
- Testing
- nonsurgical periodontal treatment, Gingival crevicular fluid and saliva collection
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Apical Periodontitis, Periapical Radiolucency
Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.
Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and…
- Trial name
- NCT07289971
- Testing
- Allium Sativum as an intracanal medicament
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Periapical Periodontitis
Comparison of Root Canal Desinfection Protocols
Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis
- Trial name
- NCT07439614
- Testing
- Desinfection device, Analytical microbiological methods
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Periodontitis
Netrin 1 and Its Receptor Unc5b as Markers of Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF), saliva and serum Netrin 1 and Unc5b levels in periodontal health and disease.
- Trial name
- NCT03919006
- Testing
- non surgical periodontal treatment, Gingival crevicular fluid, saliva and serum collection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Periodontitis
RhBMP-2 in Intrabony Defects - A Randomized Controlled Trial
This study evaluated the regenerative potential of rhBMP-2 gel in intrabony defects when compared to sticky bone (control).
- Trial name
- NCT04368650
- Testing
- BMP-2, PRF
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Periodontitis, Bruxism
Impact of Subgingival Instrumentation on Jaw Symptoms of Probable Bruxers Among Patients With Periodontitis
This study aims to explore the mechanisms by which periodontal disease affects the bruxers and to assess the impact of subgingival instrumentation on jaw symptoms of probable bruxers among patients with periodontitis .
- Trial name
- NCT06429917
- Testing
- Subgingival instrumentation
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Periodontitis
Efficacy of Subgingivally Delivered Doxycycline Plus Ketoprofen Gel as an Adjunct to Non-surgical Periodontal Treatment
Objectives: The aim of the present clinical study was to evaluate the efficacy of doxycyline 3% plus ketoprofen 2.5% as an adjunct to scaling and root planing in the treatment of chronic periodontitis(early-modearte).
- Trial name
- NCT02538224
- Testing
- 2.5%ketoprofen gel + 3 % doxycycline, :2.5%ketoprofen gel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Aggressive Periodontitis, Generalized
Comparison Between Surgical Access and Repeated Applications of APDT
The aim of this study will be to compare the approach of repeated applications of APDT versus surgical therapy for the treatment of residual pockets in generalized agressive periodontitis.
- Trial name
- NCT03140059
- Testing
- Open flap debridement, Repeated application of aPDT
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periodontitis, Adult, Smoking
Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease
The goal of this observational study is to evaluate if the measurement of salivary Interleukin (IL)-39, IL-41, IL-1Beta(β), and Tumor necrosis factor-alpha (TNF-α) levels can aid in the early diagnosis of periodontitis in…
- Conditions
- Periodontitis, Adult, Smoking, Periodontal Diseases
- Trial name
- NCT06528522
- Testing
- Clinical Measurements and Saliva Sample Collection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontitis, Periodontal Health
Asprosin Level in Individuals With Periodontal Disease
The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis…
- Conditions
- Periodontitis, Periodontal Health, Gingivitis
- Trial name
- ALIGCF (NCT06627972)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Oral Biofilm, Periodontitis
Methodology Antiseptic Application, Influence on Oral Biofilm.
The study has the objective to compare two different methodology of application the antiseptic on the oral biofilm will be formed during 48h in situ on a specific device.
- Conditions
- Oral Biofilm, Periodontitis, Gingivitis
- Trial name
- NCT02267239
- Testing
- essential oils, immersion, Chlorhexidine, immersion, essential oils, mouthwash
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Periodontitis, Periodontal Diseases
Accuracy of an AI-clinical Knowledge-based Hybrid System for Detecting Periodontitis in OPG Images
Periodontitis is highly prevalent and rarely detected and treated in the earlier stages of the disease. Orthopantomography (OPG) is the most frequently taken dental radiograph around the world, and its systematic screening may…
- Trial name
- NCT06306677
- Testing
- AI-clincial-based hybrid system for radiographic image analysis
- Where
- 3 sites in China, Hong Kong and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Revascularization
Regeneration of Immature Teeth. Case Series
This clinical study aims to investigate the predictability of revascularization procedure of immature necrotic human permanent teeth with apical periodontitis.
- Trial name
- NCT03507556
- Testing
- Triple paste and induced bleeding, Triple Paste metronidazole, ciprofloxacin and minocycline mixed with sterile glycol
- Where
- Jordan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Chronic Periodontitis
The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients
To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal…
- Trial name
- NCT03923829
- Testing
- Zinc Sulfate, scaling and root planing
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Psoriasis (PsO), Periodontal Disease
Evaluation of TNF-α, IL-17A, and YKL-40 in GCF and Serum of Psoriasis Patients and Healthy Controls
Background: Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population and is linked to immune dysregulation and systemic inflammation.
- Trial name
- NCT06897722
- Testing
- TNF-α analysis in GCF, IL-17A analysis in GCF, YKL-40 analysis in GCF
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhala Vatankha Sain
Periodontis, Atherosclerosis Cardiovascular Disease
Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study
Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses.
- Trial name
- PAROCAR (NCT07263113)
- Testing
- Periodontal examination and pulse wave velocity
- Where
- France
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
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