Clinical trials: Periodontitis
Periodontitis
Hydroxyapetite Nanoparticles, Tricalcium Phosphate Nanoparticles, and PRF for Treatment of Gingival Recession
The aim of the present study was to compare between nanocrystalline hydroxyapatite and tricalcium phosphate carried on PRP membrane in treatment of Miller's class 1 gingival recession in human.
- Trial name
- NCT06016894
- Testing
- coronally advanced flap, Nanocrystalline hydroxyapatite loaded in PRF, Nanocrystalline tricalcium phosphate loaded in PRF
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- October 6 University
Periodontitis, Hypogonadism, Male
Periodontal Profile of Hypogonadic Men
The aim of this study is to assess if hypogonadic men with periodontitis benefit from testosterone replacement therapy before being submitted to periodontal treatment.
- Trial name
- NCT03176537
- Testing
- Testosterone gel
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidade Federal do Paraná
Periodontitis, Periodontal Diseases
Histatin-1 Levels in Smokers and Non-smokers With Periodontitis Patients: A Comparative Study Before and After Nonsurgical Periodontal Therapy
This study evaluated the impact of smoking on salivary histatin-1 levels and clinical healing in 50 patients with unstable periodontitis (25 smokers and 25 non-smokers) undergoing non-surgical periodontal therapy (NSPT).
- Trial name
- NSPT (NCT07367737)
- Testing
- Non Surgical Periodontal Treatment
- Where
- Iraq
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Tooth Staining, Periodontitis
Impact of a Newly Formulated Toothpaste in Tooth Staining Associated With Chlorhexidine Rinses
Dental staining may interfere with compliance with chlorhexidine mouth rinse use Thus, developing strategies to control tooth staining associated with chlorhexidine use may be relevant for improving compliance.
- Trial name
- PaSTaining (NCT05354986)
- Testing
- Toothpaste with hexametaphosphate, tripolyphosphate and polyvinylpyrrolidone (PVP), Toothpaste without hexametaphosphate, tripolyphosphate and polyvinylpyrrolidone (PVP)
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Periodontitis, Dental Plaque
At-Home Care for Subjects With Periodontitis
The effect of use of powered toothbrushing in patients exhibiting periodontal inflammation has been observed repeatedly in clinical studies conducted over a 20+ year period.
- Trial name
- NCT04254770
- Testing
- ADA approved Manual Toothbrush, Marketed Power Toothbrush
- Where
- United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Post-Op Complication, Endodontic Inflammation
Postoperative Pain After Using NiTi Instruments
The aim of this randomized clinical trial was to compare the incidence, intensity and duration of postoperative pain following the removal of root canal obturation materials canals using rotary (ProTaper Universal or Hyflex EDM)…
- Conditions
- Post-Op Complication, Endodontic Inflammation, Endodontically Treated Teeth, Apical Periodontitis
- Trial name
- NCT04700995
- Testing
- NiTi instruments
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Trakya University
Necrotic Pulp
Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis
Earlier, it was believed that successful regeneration cannot be achieved once tooth has become infected. However, recent studies suggest that regenerative endodontics may in fact be possible in teeth with pulpal necrosis and…
- Trial name
- NCT04606719
- Testing
- Advanced Platelet Rich fibrin
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
Smoking, Cigarette
Smoking and Peptidoglycan Recognition Protein-1 and Initial Periodontal Therapy
A total of 40 patients with CP (20 smokers (S+CP) and 20 nonsmokers (S-CP)) and 40 periodontally healthy subjects (20 smokers (S+PH) and 20 nonsmokers (S-PH)), comprising 80 subjects, were included in this study.
- Trial name
- NCT03915730
- Testing
- Initial periodontal therapy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Post Operative Pain
The Effect of Diclofenac Potassium Insitu Gel Vs Calcium Hydroxide as Intra-canal Medications on Post-operative Pain and Anti-bacterial Effect
The aim of this study is to clinically compare the post-operative pain level and antibacterial effect when using the Diclofenac Potassium Insitu gel versus calcium hydroxide as an intra- canal medication in patients with apical…
- Trial name
- NCT04622488
- Testing
- Diclofenac Potassium
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Rheumatoid Arthritis, Chronic Periodontitis
Estimation of Pentraxin3 and PGingivalis Levels in Patients With Knee Joint and Gum Diseases
Periodontitis and Rhematoid arthritis are chronic inflammatory diseases which share common risk factors The purpose of this study is to determine if Pentraxin 3 and Porphyromonas Gingivalis levels play an important role in the…
- Trial name
- EP3PGKG (NCT02503046)
- Testing
- Estimation of Pentraxin3, Estimation of P.Gingivalis levels
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontal Pocket
Non-surgical Step 3 Periodontal Treatment With/Without Adjunctive Protocol - Pilot RCT.
Study conducted in patients recruited at private praxis setting after completed step 2 periodontal therapy. Residual pockets ≥4mm with positive bleeding or such >5mm randomly allocated to either conventional subgingival…
- Trial name
- NCT06438354
- Testing
- subgingival instrumentation plus Perisolv / hyaDent BG, subgingival instrumentation
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Periodontitis, Periimplantitis
PPAR, RXR, and VDR Expressions in Peri-implantitis
ABSTRACT Objective: Periodontitis and peri-implantitis are the irreversible destructive diseases of the periodontal and peri-implant tissues.
- Trial name
- NCT04020146
- Testing
- Gingival biopsies
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Periodontitis (Stage 3)
Effects of Non-Surgical Periodontal Treatment on Inflammatory and Bone Markers in Periodontitis Patients
The goal of this study is to learn how a standard treatment called Scaling and Root Planing (SRP) affects specific biochemical markers in people with advanced gum disease (periodontitis).
- Trial name
- GPNMB-PERIO St (NCT07475013)
- Testing
- Scaling and Root Planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periodontal Diseases, Cardiovascular Diseases
Analysis of Cell-free DNA (cfDNA) During Periodontitis
The purpose of this study was to examine the association between circulating cfDNA concentration and CVD risk in patients with periodontitis, CVD, and periodontitis plus CVD.
- Trial name
- NCT05590780
- Testing
- Clinical Attachment level
- Where
- Italy
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Catania
Generalized Adult Periodontitis
Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals
50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13
- Trial name
- SEGPPAH (NCT02423304)
- Testing
- blood samples collected from all patients
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis
A Safety/Tolerability and Pharmakokinetic Study of Sargramostim Administrated in the Gingiva
This exploratory study is the first study in a clinical program where the overall objective is to develop a novel pharmaceutical therapy comprising local administration of GM-CSF for the treatment of periodontitis.
- Trial name
- NCT00689143
- Testing
- sargramostim
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Innoventus Project AB
Chronic Periodontitis
RELATIONSHIP BETWEEN INITIAL PROBING DEPTH AND CHANGES IN CLINICAL PARAMETERS FOLLOWING NON-SURGICAL PERIODONTAL TREATMENT IN CHRONIC PERIODONTITIS PATIENTS
Aim: The aim of this study was to evaluate the relationship between initial probing depth (IPD) and changes in clinical parameters following non-surgical periodontal treatment (NPT) in chronic periodontitis patients.
- Trial name
- NCT02861326
- Testing
- Gracey Curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marmara University
Chronic Periodontitis, Hyaluronic Acid
Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase
Background: Chronic periodontitis is one of the most common causes of tooth loss and is rather common in the population. Treating chronic periodontitis remains a challenge for dental practitioners.
- Trial name
- NCT04675385
- Testing
- 0.2% hyaluronic acid gel
- Where
- Vietnam
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Periapical Periodontitis
Association of Apical Periodontitis With Hs-CRP and Hemogram Indices
There is lack of evidence on resolution of signs of systemic inflammatory markers by successful elimination of periapical inflammation by endodontic treatment.
- Trial name
- NCT04980768
- Testing
- Root canal treatment
- Where
- India
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Apical Periodontitis
Effect of Different Sealers and Activation Methods on Pain
In this study, the effects of different irrigation agitation methods and different root canal filling sealers on postoperative pain after root canal treatment will be evaluated.
- Trial name
- NCT06860191
- Testing
- Root Canal Sealants
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
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