Clinical trials: Periodontitis
Periapical Periodontitis, Polymerase Chain Reaction
The Effect of Ca(OH)2 in Apical Periodontitis
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Intracanal Medicament, Enterococcus Faecalis Infection
- Trial name
- NCT04978545
- Testing
- calciumhydroxide, intracanal medicament, chlorhexidine, intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Periodontitis
Effect of Novel Oral Hygiene Regimen on Non-surgical Treatment of Stage II and III Periodontitis
Achievement of adequate oral hygiene standards is critical to the successful treatment of gum disease. The improvement of the patient's adherence to good oral hygiene is of great importance to obtain the satisfactory treatment…
- Trial name
- NCT05137392
- Testing
- oral hygiene instruction
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Alveolar Bone Loss, Periodontitis
Zirconia Vs Titanium Implants in Deficient Ridges
The aim of this study is to evaluate clinically and radiographically soft tissue around single-implant crowns and peri-implant bone resorption respectively by using zirconia implants or titanium implants in horizontally deficient…
- Trial name
- NCT04375839
- Testing
- Zirconia implant, Titanium implant
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Periodontitis
Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment
Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss.
- Trial name
- NCT05583643
- Testing
- Atorvastatin Calcium, Scaling and debridement only
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Periodontitis
GCF PLAP-1, Sclerostin and TNF-α Levels in Periodontitis
Periodontal ligament-associated protein-1 (PLAP-1) and sclerostin play an important role in the suppression of bone formation. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine involved in periodontal…
- Trial name
- NCT05656989
- Testing
- Periodontal clinical measurements and GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis, Adult, Periodontal Pocket
Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients
Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant.
- Conditions
- Periodontitis, Adult, Periodontal Pocket, Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT03453476
- Testing
- SRP and Fotosan 630
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Endodontic Disease, Periapical Diseases
Comparison of Clinical Outcomes Between GentleWave® and Biolase®
Introduction: In the US, 15 million root canal treatments (RCTs) are carried out annually. Success rates decrease with conventional chemo-mechanical root canal preparation techniques used on teeth with periapical radiolucencies…
- Conditions
- Endodontic Disease, Periapical Diseases, Periapical Periodontitis, Root Canal Infection
- Trial name
- NCT05555043
- Testing
- Irrisafe ip, GentleWave System, Waterlase iPlus
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Periodontal Pocket
Dietary Intakes and Periodontal Outcomes After Sanative Therapy
Periodontitis is a chronic inflammatory disease and a significant risk factor for tooth loss. While a link between diet and periodontal health exists, the relationship between diet and healing following periodontal therapy has…
- Trial name
- NCT02291835
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Brock University
Chronic Periodontitis
Locally Delivered Metformin & Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone.
- Trial name
- NCT03204058
- Testing
- Rosuvastatin, Metformin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Pain, Postoperative, Irreversible Pulpitis
Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Trial
The aim of this study was to evaluate the effect of continuous rotation and reciprocation kinematics on post operative pain and difference in substance P levels in patients with irreversible pulpitis with symptomatic apical…
- Conditions
- Pain, Postoperative, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT06081335
- Testing
- EdgeEndo x7 continuous rotation files, EdgeOne Fire reciprocating files
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis
Immediate Implant Placement in Aggressive Periodontitis
The aim of the present study is to evaluate the health of immediately placed dental implants in aggressive periodontitis patients versus those placed in periodontally healthy individuals in the maxillary esthetic zone.
- Trial name
- implant (NCT03218228)
- Testing
- implants in periodontitis
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth Mobility, Periodontitis
Impact of MINST With and Without Splinting in Periodontitis Patients With Mobile Anterior Teeth
The goal of this clinical trial is to evaluate impact of Minimally Invasive Non-Surgical Therapy (MINST) with and without splinting on clinical periodontal parameters and Oral Health Related Quality of Life (OHRQoL) in…
- Trial name
- NCT06436729
- Testing
- Splinting, MINST alone
- Where
- India
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis
Impact of Supracrestal Tissue Attachment Dimension on Outcome of Scaling and Root Planing and Open Flap Debridement Procedure in Different Periodontal Phenotypes
The existence of supracrestal tissue attachment (SCTA) is fundamental for adhesion of the junctional epithelium and insertion of the connective fibers to the dental structure, besides functioning as a barrier against microbial…
- Trial name
- NCT05696600
- Testing
- Scaling and root planing and open flap debridement
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Pocket, Periodontitis
PRF Therapy for Pocket Reduction
Periodontal regenerative therapy has focused on various non-surgical and surgical treatment methods. Platelet-rich fibrin (PRF) has shown to possess multiple uses, including properties that promote healing of both soft and hard…
- Trial name
- NCT05908929
- Testing
- SRP and concomitant insertion of PRF membrane, SRP
- Where
- 2 sites in Italy
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Federico II University
Necrotic Pulp with Symptomatic Apical Periodontitis, Postoperative Dental Pain
Evaluation of Postoperative Pain and Antimicrobial Efficacy of Selenium Versus Calcium Hydroxide As Intracanal Medication in Mandibular First Molars with Necrotic Pulp and Symptomatic Apical Periodontitis
The main rational behind intracanal medicament is to kill the bacteria inside the root canal and to avert reinfection. In absence of nutrients, the bacteria remains after obturation in root canal may not survive.
- Conditions
- Necrotic Pulp with Symptomatic Apical Periodontitis, Postoperative Dental Pain, Antimicrobial Effect
- Trial name
- NCT06804330
- Testing
- root canal treatment and intracanal medicament
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Chronic Periodontitis, Smoking
Adjunct Photodynamic Therapy in Chronic Periodontitis Among Cigarette-smokers.
This study evaluates the efficacy of scaling and root planing with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of chronic periodontitis (CP) among cigarette-smokers and never-smokers.
- Trial name
- NCT03308019
- Testing
- Photodynamic therapy, Scaling and root planing (SRP)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- King Saud University
Periodontal Bone Loss, Periodontal Pocket
Locally Injected Vit D as a Non-surgical Modality for Periodontal Regeneration of Infrabony Defects
vitamin D has great role in bone regenration and soft tissue health. in the past periodontal regeneration was performed using bone graft and barrier membrane
- Trial name
- NCT03716765
- Testing
- locally injected vitamin D
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Gingivitis
Signal-Transducing Adaptor Proteins in Periodontal Disease
This study will look at certain proteins in the gums, saliva, and gum fluid of people with healthy gums, gingivitis (mild gum inflammation), or periodontitis (more severe gum disease).
- Trial name
- NCT07751393
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Inonu University
Periodontitis, Periodontal Pocket
Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel
In the here suggested study, the aim is to test non-surgical treatment of advanced periodontal disease with a chitosan brush with or without chitosan gel in patients with advanced periodontal disease having responded poorly to a…
- Conditions
- Periodontitis, Periodontal Pocket, Periodontal Diseases, Periodontal Inflammation
- Trial name
- Chitosangel (NCT05773911)
- Testing
- 4% chitosan gel (pH 3.48)., Reciprocal Chitosan brush
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Caspar Wohlfahrt
Chronic Periodontitis
Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis.
Aim of the study is the efficiency assessment of porous Metronidazole loaded matrix based on gelatin/hydroxyethylcellulose blend in treatment of deep periodontal pockets resulting from severe chronic periodontitis.
- Trial name
- NCT03791099
- Testing
- Metronidazole
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
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