Clinical trials: Periodontitis (Stage 3)
Periodontitis Stage III
Clinical and Laboratory Evaluation of Resveratrol Loaded Nanoparticles in the Treatment of Periodontitis: A Randomized Controlled Clinical Trial
The Aim of this study is to test the effectiveness of locally applied resveratrol as an adjunct to scaling and root planing in the treatment of periodontitis (primary outcome) .
- Trial name
- NCT07397026
- Testing
- Resveratrol loaded gel
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hagar Ahmed Ali Mohammed Elzain
Periodontitis Stage III, Periodontitis Stage IV
Blood Glucose Screening in Patients With Advanced Periodontits: the Role of Specialist Periodontal Care in Identifying Hyperglycaemia and Supporting Patient Centered Treatment
Periodontitis is a chronic inflammatory disease and individuals with advanced periodontitis have an increased risk of hyperglycaemia.
- Conditions
- Periodontitis Stage III, Periodontitis Stage IV, Diabetes (DM), Prediabetes
- Trial name
- NCT07426224
- Testing
- Selective screening of blood glucose/HbA1c
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Folktandvården Stockholms län AB
Periodontitis
Occlusal Force and Chewing After Periodontal Therapy
Stage III and Stage IV periodontitis are associated with loss of periodontal support, tooth mobility, and impaired oral function, which may affect occlusal force distribution and chewing performance.
- Trial name
- NCT07772115
- Testing
- Non-Surgical Periodontal Therapy
- Volunteers
- 30 people
- Sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences
Periodontal Pocket
Evaluation of iPRF With Vit.D As an Adjunct to Non-Surgical Therapy in the Treatment of Stage III Periodontitis
a clinical trial will be made to investigate the effect of locally applied injectable prf (iPRF) plus vitamin D on the periodontal pockets in stage III periodontitis patients
- Trial name
- NCT06570200
- Testing
- PMPR+iPRF, PMPR+iPRF+Vit.D, PMPR only
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Periodontitis Stage III and IV and Oral Health Related Quality of Life
Patients diagnosed with stage III or IV periodontitis during routine visits at the department of periodontology will undergo a validated questionnaire to understand the impact of the disease on their quality of life.
- Trial name
- NCT05481567
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Cagliari
Vitamin D Deficiency, Periodontitis
25-Hydroxyvitamin D Levels in Patients With Periodontitis (Stage III)
Periodontitis; is an inflammatory disease of tissues characterized by bone destruction around the teeth. Vitamin D plays an important role in several inflammatory diseases by promoting the expression of inflammatory cytokines…
- Trial name
- NCT05343273
- Testing
- taking a blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Periodontitis
Trial to Evaluate Safety, Tolerability, Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis
A Phase 2, uncontrolled, open-label, single arm study to evaluate the safety, tolerability and efficacy of PerioSept® (3%) as adjunct to Scaling and Root Planing in subjects with periodontitis.
- Trial name
- NCT04093895
- Testing
- PerioSept(r)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Geistlich Pharma AG
Palmoplantar Pustulosis
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis
The purpose of this study is to evaluate the efficacy and safety of bimekizumab compared with placebo in participants with palmoplantar pustulosis (PPP).
- Trial name
- BeSeen (NCT07219420)
- Testing
- Bimekizumab
- Where
- 91 sites in United States, Canada and 11 more
- Volunteers
- 320 people
- Sponsor
- UCB Biopharma SRL
Periodontitis, Periodontitis (Stage 3)
Periodontal Dressings in Non-Surgical Therapy
This study aims to evaluate and compare the efficacy of two different eugenol-free periodontal dressing materials-Ora-Aid (a hydrophilic polymer) and Coe-Pak (a zinc oxide-based paste)-following non-surgical periodontal treatment…
- Conditions
- Periodontitis, Periodontitis (Stage 3), Periodontal Pocket
- Trial name
- NCT07472218
- Testing
- Ora Aid application, Coe-Pack application
- Volunteers
- 25 people
- Sponsor
- Saglik Bilimleri Universitesi
Periodontal Diseases, Periodontitis (Stage 3)
Influence of Re-evaluation Timing After Phase I Periodontal Therapy on Clinical and Periodontal Outcomes.
Periodontal disease remains a highly prevalent chronic inflammatory condition affecting the supporting structures of the teeth and is a leading cause of tooth loss worldwide.
- Conditions
- Periodontal Diseases, Periodontitis (Stage 3), Subgingival Debridement
- Trial name
- NCT07678125
- Testing
- Early follow up, Delayed follow up
- Where
- United Arab Emirates
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Periodontitis, Probiotic
Patient-Reported Probiotic Use During Periodontal Therapy in Periodontitis
Most previous studies have evaluated standardized probiotic regimens as adjuncts to NSPT (Ausenda et al., 2023; Hardan et al., 2022; Mauriello et al., 2025).
- Conditions
- Periodontitis, Probiotic, Oral Hygiene, Oral Health, Periodontal Therapy
- Trial name
- NCT07619040
- Testing
- non surgical periodontal therapy
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Medipol University
Periodontitis, Periodontitis Stage III
Alb-PRF as an Adjunct to Regenerative Periodontal Surgery
Periodontitis is characterized by the progressive destruction of tooth-supporting tissues and may lead to the formation of intrabony periodontal defects.
- Conditions
- Periodontitis, Periodontitis Stage III, Periodontal Intrabony Defects
- Trial name
- NCT07805317
- Testing
- Regenerative Periodontal Surgery With EDTA and Allogeneic Bone Graft, Albumin Platelet-Rich Fibrin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Halil Ata BIÇAKÇIOĞLU
Intrabony Periodontal Defects
Minimally Invasive Non-Surgical Therapy Versus Single Flap Approach in Management of Periodontal Intrabony Defects
This study aims to evaluate the clinical and 3D radiographic effects of minimally invasive non-surgical periodontal therapy (MINST) compared to single flap approach (SFA) in management of intrabony defects in stage III or IV…
- Trial name
- NCT07822659
- Testing
- minimally invasive non-surgical therapy, minimally invasive periodontal surgery
- Volunteers
- 40 people
- Sponsor
- Cairo University
Periodontal Diseases
Effect of Internal and External Micro-needling in Treatment of Stage III Periodontitis
Periodontitis is a dysbiotic disease characterized by the destruction of the periodontium (alveolar bone, cementum, periodontal ligament, gingiva) and considered the main cause of tooth loss which is linked to a change in the…
- Trial name
- NCT06578403
- Testing
- external microneedling, minimally invasive non- surgical periodontal therapy, internal micro_needling
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Periodontitis, Bruxism
Impact of Bruxism in the Outcome of Subgingival Instrumentation for the Management of Stage 2 and Stage 3 Periodontitis.
Bruxism is a multifaceted phenomenon that has been associated with several factors mediated by the central nervous system3. Bruxism is an umbrella term grouping different motor phenomenon.
- Trial name
- NCT05995431
- Testing
- scaling and root planing, Subgingival instrumentation
- Where
- India
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis
Effectiveness of Adjunctive Therapy of Emdogain®FL in Non-surgical Periodontal Treatment
The goal of this clinical trial is to assess the safety and effectiveness of adjunctive Emdogain® therapy in non-surgical periodontal treatment for patients with stage 3 and 4 periodontitis.
- Trial name
- NCT06070181
- Testing
- Enamel matrix derivate, Non-surgical periodontal treatment
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Ostergotland County Council, Sweden
Stress, Psychological, Periodontal Diseases
Effect of Stress on Periodontal Therapy (NPT)
Aim of this study: is to evaluate the influence of stress level on the response of non surgical periodontal therapy in patients affected by severe periodontitis divided into "Medium/High stress level" or "Low stress level" based…
- Conditions
- Stress, Psychological, Periodontal Diseases, Periodontitis, Non Surgical Periodontal Therapy
- Trial name
- NCT04739475
- Testing
- Non Surgical Periodontal Therapy
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- University of Turin, Italy
Periodontitis
Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel
The goal of this clinical trial is to compare the efficacy of Noisome as carrier of minocycline hydrochloride gel to minocycline hydrochloride in Stage II or Stage III Periodontitis .
- Trial name
- NCT06255067
- Testing
- Minocycline hydrochloride with noisome carrier, Minocycline Hydrochloride only
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Periodontitis (Stage 3)
Effects of the Adjunctive Use of Hyaluronic Acid-based Gel in the Surgical Periodontal Treatment of Periodontitis
This study aimed to assess the effect of Hyaluronic Acid-based gel as an adjunctive chemotherapeutic agent in surgical periodontal treatment on clinical parameters and cytokine levels (IL-6, IL-8, IL-10, IL-17A, TOS, and TAS) in…
- Trial name
- Periodontit (NCT06842511)
- Testing
- open flap debridement and Hyaluronic Acid-Based Gel application, open flap debridement
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Ordu University
Periodontal Pocket, Periodontitis
Multicenter Study on the Use of a Collagen-based Hydrogel for the Treatment of 153 Periodontal Pockets in 38 Adults With Generalized Stage III Periodontitis
This is a prospective, observational, multicenter study designed to evaluate the real-world efficacy and safety of H42®, a collagen hydrogel, in the treatment of periodontal pockets.
- Trial name
- NCT07592377
- Testing
- H42® Collagen Hydrogel for the non-surgical treatment of periodontal pockets
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- Bioteck S.p.A.