Clinical trials: Perioperative/Postoperative Complications
Thyroid Diseases
Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery
Thyroid surgery requires smooth emergence from anesthesia to minimize coughing, hemodynamic fluctuations, and agitation during extubation, which may contribute to postoperative complications such as bleeding or cervical hematoma.
- Trial name
- DEX-THYROID (NCT07462195)
- Testing
- Dexmedetomidine, Standard General Anesthesia
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Bach Mai Hospital
Cardiac Ischemia, Thoracic Cancer
Perioperative Troponin I and NT Pro-BNP in Lung Resection
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery.
- Conditions
- Cardiac Ischemia, Thoracic Cancer, Complication,Postoperative
- Trial name
- NCT04749212
- Testing
- serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP)
- Where
- Spain
- Volunteers
- 475 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Surgery, Perioperative Complication
Post Discharge After Surgery Virtual Care With Remote Automated Monitoring Technology (PVC-RAM) Trial
The Post discharge after surgery Virtual Care with Remote Automated Monitoring technology (PVC-RAM) Trial is a multicentre, parallel group, superiority, randomized controlled trial to determine the effect of virtual care with…
- Conditions
- Surgery, Perioperative Complication, COVID
- Trial name
- PVC-RAM (NCT04344665)
- Testing
- Virtual Care and Remote Automated Monitoring
- Where
- 7 sites in Canada
- Volunteers
- 905 people
- Sponsor
- Population Health Research Institute
Perioperative/Postoperative Complications, C.Surgical Procedure; Digestive System
Non-invasive Early Goal Directed Therapy in Colorectal Surgery: a Feasibility Study
The Nexfin monitoring system offers a complete non-invasive approach to a continuously estimation of blood pressure, CI and PPV by means of finger-cuff based pulse contour analysis.
- Trial name
- NCT02559141
- Testing
- Dobutamine
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Schleswig-Holstein
Thoracic Surgery With One-lung Ventilation, VExUS
Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery
This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute…
- Conditions
- Thoracic Surgery With One-lung Ventilation, VExUS, Fluid Management, Acute Kidney Injury
- Trial name
- VEXUS (NCT07258875)
- Testing
- Venous Excess Ultrasound, Standard of Care (SOC)
- Where
- Greece
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of Crete
Cervical Cancer, Endometrial Cancer
Epidural Analgesia or Patient-Controlled Analgesia in Treating Patients Who Have Undergone Surgery for Gynecologic Cancer
RATIONALE: Giving pain medication into the space between the wall of the spinal canal and the covering of the spinal cord or giving it into a vein may help lessen pain caused by cancer surgery.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00295945
- Testing
- fentanyl citrate, hydromorphone hydrochloride, ropivacaine hydrochloride
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Pain, Postoperative
Effect of Perioperative Intravenous Lidocaine on Opioid Consumption and Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernioplasty
The primary objectives of this study is to access the effect of perioperative lidocaine infusion on total morphine requirement during the first 24 h postoperatively in patients who underwent laparoscopic totally extraperitoneal…
- Trial name
- NCT02601651
- Testing
- Lidocaine, Normal saline
- Where
- Nepal
- Volunteers
- 64 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Postoperative Pulmonary Complications (PPCs), Hypoxemia
Lung Ultrasound Score and Postoperative Pulmonary Complications in Major Non-Thoracic Surgery
This prospective observational cohort study aims to evaluate the predictive value of perioperative lung ultrasound (LUS) score in determining early postoperative oxygen requirement and pulmonary complications in patients…
- Trial name
- LUS-POSTOP (NCT07515001)
- Volunteers
- 97 people
- Sponsor
- Dicle University
Complication of Coronary Artery Bypass Graft, Peri-operative Hemorrhage or Hematoma
Platelet Reactivity in Patients on a Thienopyridine and Awaiting Coronary Artery Bypass Grafting
The primary objective of this exploratory cohort study is to describe levels of platelet reactivity in patients on a thienopyridine awaiting coronary artery bypass grafting (CABG).
- Conditions
- Complication of Coronary Artery Bypass Graft, Peri-operative Hemorrhage or Hematoma, Post Operative Bleeding
- Trial name
- Serial CABG (NCT01406483)
- Testing
- Platelet reactivity assessment
- Volunteers
- 75 people
- Sponsor
- Medstar Health Research Institute
Pain, Postoperative, Cognitive Function Abnormal
Perioperative Cognitive Training in Thoracic Surgery
More than 30% of patients undergoing thoracic surgical procedures develop persistent post-surgical pain (PPSP), which results in impaired functioning, diminished quality of life, and increased risk of chronic opioid use.
- Conditions
- Pain, Postoperative, Cognitive Function Abnormal, Lung Cancer
- Trial name
- COFLEX-T (NCT04563234)
- Testing
- COFLEX neurocognitive training, Crossword puzzles
- Sponsor
- Washington University School of Medicine
Pain, Postsurgical
Weighted Blankets for Postsurgical Pain
The strongest psychological predictor of persistent pain after surgery is anxiety before surgery. The weight of blanket a person uses overnight may alter both anxiety and pain levels.
- Trial name
- NCT05324254
- Testing
- Weighted blanket
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- University of California, San Diego
Perioperative Complication
Effectiveness of Intensive Perioperative Nutrition Therapy Among Adults Undergoing Gastrointestinal & Oncology Surgery
Perioperative malnutrition is common in patients undergoing gastrointestinal and oncological surgery and it also associated with longer hospital stays, reduced responses to and increased complications from therapies, increased…
- Trial name
- NCT04347772
- Testing
- Oral Nutrition Support
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Kidney Transplant; Complications
Perioperative Goal Directed Therapy in Kidney Transplantation
In literature there is a huge amount of works demonstrating the direct correlation between volemic overload or fluid deficit and hypoperfusion and the increase in the rate of major postoperative complications in patients with…
- Trial name
- NCT03776396
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- University of Catania
Overactive Bladder
Over Active Bladder Patients Having Sling Surgery
The purpose of this study is to determine whether treatment with anti-muscarinic medications following sub-urethral sling procedures improves overall subjective and objective outcomes in women with mixed incontinence with primary…
- Trial name
- NCT00852696
- Testing
- Solifenacin
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Cleveland Clinic Florida
Carotid Stenosis, Postoperative Cognitive Dysfunction
Neurocognitive Function After Carotid Thrombendarterectomy
Previous studies did not reach a consensus on the influence of the type of anesthesiologic procedure and monitoring, during carotid thrombendarterectomy, on perioperative complications and cognitive outcomes.
- Conditions
- Carotid Stenosis, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT05739357
- Testing
- NIRS, EEG
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Renal Failure
Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery
pain control in pediatric renal transplant is a major concern. the main goal during anesthesia of renal transplant in pediatrics is to maintain hemodynamics in a range close to that of the adult donor.
- Trial name
- NCT02037802
- Testing
- B-Braun, Perifix® ONE Paed, Germany, Pethidine, Propofol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Pain
Double-Blind, Randomized Study Of The Analgesic Efficacy And Safety Of Valdecoxib 20 Mg Daily And Valdecoxib 20 Mg Twice Daily Compared To Placebo For Management Of Acute Postsurgical Pain In Anterior Cruciate Ligament (ACL) Reconstruction
The primary objective was to evaluate the analgesic efficacy of valdecoxib 20 mg daily and valdecoxib 20 mg twice daily compared with placebo in outpatients with moderate-severe pain after arthroscopic anterior cruciate ligament…
- Trial name
- NCT00650039
- Testing
- valdecoxib
- Where
- 81 sites in United States, Canada
- Volunteers
- 488 people
- Sponsor
- Pfizer
Blood Loss, Postoperative, Blood Loss, Surgical
EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDY
Perioperative blood loss is one of the most frequently encountered and significant complications of spine surgery. Intraoperative and post-operative bleeding cause various complications and negatively affect patient outcomes.
- Conditions
- Blood Loss, Postoperative, Blood Loss, Surgical, Femoral Fracture, Tibial Fracture
- Trial name
- NCT07625709
- Testing
- Intervention with Tranexamic Acid, Control group (Normal Saline)
- Where
- Nepal
- Volunteers
- 54 people
- Sponsor
- Kathmandu University School of Medical Sciences
Scoliosis
Sensorial and Physiological Mechanism-based Assessments of Perioperative Pain
The overall goal of this proposal is to determine if quantitative sensory testing (QST) assessing pain modulation can be used as a clinical tool to optimize perioperative pain management.
- Trial name
- RCT (NCT03537612)
- Testing
- Clonidine, Morphine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Dr. Jean A. Ouellet, MD, FRCSC
Surgical Site Infection, Post-Op Complication
Perioperative Immunonutrition in Patients Undergoing Gynecologic or General Elective Surgery (PURPOSE)
The objective of the implementation pilot is to assess the practicality of introducing a perioperative immunonutrition protocol into a hospital environment as well as a true measure of impact on the rate of surgical site…
- Trial name
- PURPOSE (NCT04057092)
- Testing
- Dietary Supplement INergy-FLD
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation