Clinical trials: Perioperative/Postoperative Complications
Patient Readmission
Predicting Hospital Readmission for Surgical Patients Using Deep Learning Models With Smart Watch and Smart Ring Sensors Data
Hospital readmissions are an important measure of healthcare quality and safety. These events create a substantial burden for patients, families, and health systems because they may increase costs, extend recovery time, and lead…
- Trial name
- NCT07349901
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Getúlio Vargas University Hospital
Surgery, Perioperative Complication
Post Discharge After Surgery Virtual Care With Remote Automated Monitoring Technology (PVC-RAM) Trial
The Post discharge after surgery Virtual Care with Remote Automated Monitoring technology (PVC-RAM) Trial is a multicentre, parallel group, superiority, randomized controlled trial to determine the effect of virtual care with…
- Conditions
- Surgery, Perioperative Complication, COVID
- Trial name
- PVC-RAM (NCT04344665)
- Testing
- Virtual Care and Remote Automated Monitoring
- Where
- 7 sites in Canada
- Volunteers
- 905 people
- Sponsor
- Population Health Research Institute
Robotic Esophagectomy
Impact of Perioperative Shedding of the Endothelial Glycocalyx on Short-term Postoperative Complication in Patients Undergoing Robot-assisted Esophagectomy
The aim of this study was to determine whether changes in serum levels of syndecan-1 before and after surgery, which is an index related to injury of the endothelial glycocalyx layer, are associated with postoperative short-term…
- Trial name
- NCT03699878
- Where
- South Korea
- Volunteers
- 221 people
- Sponsor
- Yonsei University
Liver Transplantation, Ischaemia Reperfusion Injury
Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation
Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management.
- Conditions
- Liver Transplantation, Ischaemia Reperfusion Injury, Perioperative Complications
- Trial name
- NCT07631689
- Testing
- Reperfusion Blood Discard, Standard Liver Transplantation
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo General Hospital
Postoperative Blood Loss
Effect of Early Administration of TXA in Adult Hip Fractures
This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center.
- Trial name
- NCT05047133
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ascension Health
Nephrectomy / Methods, Intraoperative Hypothermia
Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective Nephrectomy
The goal of this observational study is to learn whether warming patients before surgery, called "prewarming," affects blood lactate levels (a marker of how well tissues are getting oxygen) and recovery in adults having planned…
- Conditions
- Nephrectomy / Methods, Intraoperative Hypothermia, Hyperlactatemia
- Trial name
- NCT07702487
- Testing
- Preoperative active warming (prewarming)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Beyzanur Aydoğdu
Cardiac Pacing, Permanent Pacemaker Implantation
Ultrasound-Guided PECS II Block for Permanent Pacemaker Implantation
This single-center, prospective, randomized, controlled clinical trial aims to evaluate whether ultrasound-guided PECS II block, when added to standard local infiltration anesthesia, improves perioperative analgesia in patients…
- Conditions
- Cardiac Pacing, Permanent Pacemaker Implantation, Postoperative Pain
- Trial name
- PACE-PECS (NCT07739407)
- Testing
- Ultrasound-Guided PECS II Block, Standard Local Infiltration Anesthesia
- Volunteers
- 72 people
- Sponsor
- ferdi gülaştı
Blood Loss, Postoperative, Blood Loss, Surgical
EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDY
Perioperative blood loss is one of the most frequently encountered and significant complications of spine surgery. Intraoperative and post-operative bleeding cause various complications and negatively affect patient outcomes.
- Conditions
- Blood Loss, Postoperative, Blood Loss, Surgical, Femoral Fracture, Tibial Fracture
- Trial name
- NCT07625709
- Testing
- Intervention with Tranexamic Acid, Control group (Normal Saline)
- Where
- Nepal
- Volunteers
- 54 people
- Sponsor
- Kathmandu University School of Medical Sciences
Abdominal Aortic Aneurism, Abdominal Aortic Rupture
Haemostasis Management of Abdominal Aortic Procedures
Comparative study on efficacy of haemostatic therapy guided either by standard laboratory coagulation parameters or point-of-care testing in patients undergoing vascular surgical procedures.
- Conditions
- Abdominal Aortic Aneurism, Abdominal Aortic Rupture, Perioperative/Postoperative Complications, Surgical Blood Loss
- Trial name
- NCT03426839
- Testing
- Coagulation tests
- Volunteers
- 40 people
- Sponsor
- University of Pecs
Pain, Postoperative, Opioid Use Disorder
Patient Engagement in Perioperative Pain Management Project
Previously, the study team evaluated the implementation and effectiveness of the Johns Hopkins Perioperative Pain Program (PPP), which coordinates continuum of care for surgical patients on chronic opioid therapy throughout the…
- Trial name
- NCT05252767
- Testing
- Patient Engagement Tools, Educational Guide
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Johns Hopkins University
Chronic Post-surgical Pain
Duloxetine to Prevent Chronic Postsurgical Pain After Inguinal Hernia Repair in Patients at High Risk
The clinical trial will be conducted in 14 Spanish hospitals. It is estimated, based on our previous studies, that 2855 patients scheduled for elective inguinal hernia surgery will have to be assessed to detect patients with ≥…
- Trial name
- GENDOLCAT3 (NCT06606067)
- Testing
- Duloxetine
- Where
- Spain
- Volunteers
- 294 people
- Sponsor
- Parc de Salut Mar
Endometrium Cancer, Sentinel Lymph Node
Multimedia Aid Gynecologic Counseling and Consent
This is an interventional trial to introduce two short animated videos into preoperative counseling/consent and to compare patient comprehension and satisfaction with a multimedia approach compared to standard of care currently.
- Conditions
- Endometrium Cancer, Sentinel Lymph Node, Perioperative/Postoperative Complications
- Trial name
- NCT03899441
- Testing
- Video
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Post Operative Vasoplegic Syndrome, Acute Kidney Injury
POLECAT: Perioperative Delta Renin Concentration
We want to measure the amount of a hormone called renin in people's bodies before and after they have major abdominal surgery. We want to see if changes in renin levels are connected to problems with blood flow, unstable blood…
- Trial name
- POLECAT (NCT05942846)
- Volunteers
- 405 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Rebound Pain, Total Knee Arthroplasty
Heart Rate Variability as a Predictor of Rebound Pain Following Total Knee Arthroplasty
This study aims to investigate whether heart rate variability (HRV), a marker of autonomic nervous system activity, can predict the occurrence of rebound pain after total knee arthroplasty (TKA).
- Conditions
- Rebound Pain, Total Knee Arthroplasty, Postoperative Pain, Chronic, Heart Rate Variability
- Trial name
- NCT06977191
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Konya City Hospital
Postoperative Complications, Appendicitis
Impact of SARS-Cov2 Pandemic on Severity of Perioperative Complications in Patients Undergoing Appendectomy
There are 2 types of surgical procedures to remove the appendix : open appendectomy or laparoscopic appendectomy. About 60000 appendectomies are performed every year in France.
- Conditions
- Postoperative Complications, Appendicitis, COVID-19 Pandemic, Appendicitis With Peritonitis
- Trial name
- SAP-19 (NCT05178251)
- Testing
- appendectomy
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Abdominal Surgery, Postoperative Recovery
Effect of AI-Personalized Virtual Reality on Postoperative Recovery After Major Abdominal Surgery
Major abdominal surgery is frequently associated with postoperative pain, anxiety, delayed recovery, and prolonged hospitalization.
- Conditions
- Abdominal Surgery, Postoperative Recovery, Postoperative Pain, Length of Hospital Stay
- Trial name
- VR-RECOVER (NCT07493499)
- Testing
- Immersive Virtual Reality (VR), Standard Perioperative Care and Enhanced Recovery Protocol
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Alexandria University
Laminectomy
The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy
The purpose of this research is to determine the pain-reducing effects of ketamine (Ketalar, an FDA-approved drug for anesthesia) and methadone (Dolophine, a long-acting narcotic) after lumbar laminectomy.
- Trial name
- NCT02252432
- Testing
- Ketamine, Methadone, Ketamine + methadone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Cedars-Sinai Medical Center
Cholecystectomy, Laparoscopic, Anesthesia, General
Effect of Pupilometer Guided Analgesia on Postoperative Pain
In this study, the investigators measure a pupil size every 5 minutes during the operation in patients undergoing laparoscopic cholecystectomy under general anesthesia.
- Conditions
- Cholecystectomy, Laparoscopic, Anesthesia, General, Reflex, Pupillary
- Trial name
- PUPIL_pain (NCT03794271)
- Testing
- Pupilometer guided anesthesia, SPI guided anesthesia
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Daegu Catholic University Medical Center
Blood Loss, Postoperative
Perioperative Blood Transfusion in Open Liver Resection
This observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures.
- Trial name
- NCT06189911
- Testing
- Open liver resection
- Volunteers
- 1,201 people
- Sponsor
- Chiang Mai University
Anastomotic Leak
Risk Factors Associated With Anastomotic Leak and Perioperative Mortality in Elderly
This is a retrospective cohort study of all consecutive patients who underwent colon or rectal resection, between the years 2012-2017 at Rabin Medical Center, a tertiary referral center in Israel.
- Trial name
- NCT04518384
- Testing
- colon or rectum resection
- Where
- Israel
- Volunteers
- 536 people
- Sponsor
- Rabin Medical Center