Clinical trials: Perioperative/Postoperative Complications
Endometriosis
Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial.
Endometriosis is a chronic condition affecting approximately 10% of women. It is frequently associated with persistent or recurrent pelvic and abdominal pain.
- Trial name
- ENDPAIN (NCT07881562)
- Testing
- Esketamine
- Volunteers
- 1,000 people
- Sponsor
- Region Skane
Hip Fractures, Hypotension on Induction
Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.
Background During anaesthesia for repair of a broken hip, many patients experience low blood pressure. There have been many studies showing that patients who experience low blood pressure during anaesthesia are at increased risk…
- Conditions
- Hip Fractures, Hypotension on Induction, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- iSTABILISE (NCT04051073)
- Testing
- Continuous non-invasive blood pressure monitoring
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Observation, Postoperative
Proteomics and Physiological Parameters Predicting Complications After Colorectal Cancer Surgery
Study combines physiological data from wearables, continuous glucose montiors and proteomics to better assess risk of complications after colorectal surgery
- Trial name
- ProComp (NCT07494669)
- Testing
- Risk stratification with proteomics and data from wearables and CGMs
- Volunteers
- 210 people
- Sponsor
- Region Skane
Radical Cystectomy, Surgical Site Infection
Optimized Perioperative Antibiotic Prophylaxis in Radical Cystectomy
Cystectomy with urinary diversion (ileal conduit, orthotopic ileal bladder substitute, continent catheterizable pouch) is the best treatment option for patients with muscle-invasive bladder cancer.
- Conditions
- Radical Cystectomy, Surgical Site Infection, Urologic Cancer, Perioperative/Postoperative Complications
- Trial name
- PAPRAC (NCT03305627)
- Testing
- Short PAP, Extended PAP
- Where
- 2 sites in Switzerland
- Volunteers
- 196 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Major Abdominal Surgery, Perioperative Haemodynamic Monitoring
Continuous Central Venous Oxygen Saturation Assisted Intraoperative Hemodynamic Management
Patients who are scheduled for: elective oesophageal tumour resection, total gastrectomy, pancreas resection, major vascular, total cystectomy will be recruited.To investigate effects of central venous pressure (CVP) and central…
- Conditions
- Major Abdominal Surgery, Perioperative Haemodynamic Monitoring, Perioperative Fluid Management, Perioperative Vasopressor Requirement
- Trial name
- NCT02337010
- Testing
- CeVOX, CVP, Fluid bolus
- Where
- Hungary
- Volunteers
- 79 people
- Sponsor
- Domonkos Trásy
Acute Post-operative Pain
Panda: Evaluation of a Smartphone-based Perioperative Pain Assessment Tool
This study will evaluate Panda, a smartphone-based pain assessment tool. During a child's recovery from surgery, a Post-Anesthetic Care Unit nurse will assess their pain, which helps determine what medication they need.
- Trial name
- Panda (NCT01610882)
- Testing
- Panda first followed by manual pain assessment, Manual first followed by Panda pain assessment
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- University of British Columbia
Perioperative Respiratory Adverse Events, Postoperative Respiratory Complications
Ultrasonographic Subglottic Airway Measurements and Postoperative Respiratory Events in Young Children
This study aims to better understand airway-related respiratory events that may occur in children under three years of age undergoing general anesthesia with a laryngeal mask airway (LMA).
- Trial name
- NCT07394686
- Testing
- Serial subglottic airway ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Acute Pain
The Effect of Erector Spinae Plane Block Performed Under Direct Vision on Postoperative Pain in Spine Surgery
Spine surgery is typically associated with severe postoperative pain. Although the number of spine surgeries has increased day by day, postoperative pain management have been limited.
- Trial name
- ESPOUSES (NCT03960528)
- Testing
- Erector spinae plane block, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Bezmialem Vakif University
Perioperative/Postoperative Complications, Surgery
Validity of Aortic Pulse Wave Velocity in Predicting the 6- Minute Walking Test Before Major Non-cardiac Surgery
Methods: Prospective observational study in adult patients requiring preoperative evaluation Objectives: To determine the correlation between the aortic pulse wave velocity (AoPWV) and the distance walked in the 6-minute walk…
- Conditions
- Perioperative/Postoperative Complications, Surgery, Exercise Tolerance
- Trial name
- 6WAVE (NCT03866915)
- Testing
- Aortic pulse wave velocity measurement, 6 minutes walking test
- Where
- 3 sites in Spain
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Grupo Español de Rehabilitación Multimodal
Chronic Pain, Knee Pain Chronic
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total…
- Conditions
- Chronic Pain, Knee Pain Chronic, Post Operative Pain
- Trial name
- PROVISION (NCT06123715)
- Testing
- Vitamin C
- Where
- 3 sites in Canada
- Volunteers
- 400 people
- Sponsor
- University Health Network, Toronto
Surgical Blood Loss, Surgery
Modeling of the Hemoglobin Drop in the Uncomplicated Postoperative Course
transfusion-related decisions in the perioperative setting are often complex due to acute variations in the hemoglobin levels, which typically experience a progressive decrease within days.
- Conditions
- Surgical Blood Loss, Surgery, Perioperative/Postoperative Complications
- Trial name
- NCT03740438
- Testing
- Hemoglobin concentration
- Where
- Spain
- Volunteers
- 154 people
- Sponsor
- Hospital Clinic of Barcelona
Myocardial Injury, Myocardial Infarction
Prevention of Myocardial Injury in Non-cardiac Surgery
Worldwide, more than 200 million patients have major non-cardiac surgery annually and a significant proportion of these patients suffer major cardiovascular complications (e.g.
- Trial name
- PIXIE (NCT02344797)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in Denmark
- Volunteers
- 573 people
- Sponsor
- Zealand University Hospital
Delirium - Postoperative
Perioperative Antibiotic Exposure and Postoperative Delirium in Older Adults Undergoing Elective Non-cardiac Surgery: A Single-center Prospective Cohort Study
This study aimed to characterize the current patterns of perioperative prophylactic antibiotic use and to systematically evaluate the association between different antibiotic classes and the occurrence of POD, thereby providing…
- Trial name
- NCT07673510
- Testing
- Perioperative antibiotics exposure
- Where
- China
- Volunteers
- 4,711 people
- Sponsor
- Chinese PLA General Hospital
Pain, Postoperative
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
Laparoscopic colorectal surgery (LCS) has gained wide acceptance in the treatment of various pathology from diverticular disease to colon cancer.
- Trial name
- NCT02086123
- Testing
- Epidural Analgesia, Parenteral Analgesia (Intravenous)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Irvine
Blood Pressure, Perioperative/Postoperative Complications
SOMNOmedics Clinical Validation Trial
Observational study in which pulse transit time (PTT) as a method and the device to register this data is compared with arterial blood pressure.
- Trial name
- NCT03307889
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Colorectal Surgery, Postoperative Complications
Restricted Fluid Therapy in Colorectal Surgery
This is a protocol for a trial carried out from 1999 to 2002. At that time, surgical patients received a large volume of intravenous saline during operations on the colon or the rectum, often so much fluid that their bodyweight…
- Trial name
- NCT03537989
- Testing
- Saline
- Volunteers
- 172 people
- Sponsor
- Holbaek Sygehus
Ischemia Reperfusion Injury
Safety and Efficacy of Treprostinil in Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplantation
The overall purpose of this study is to evaluate the safety, pharmacokinetics and preliminary efficacy of a five-days post-operative course of Treprostinil in liver transplant patients.
- Trial name
- NCT01481974
- Testing
- Treprostinil
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Abhinav Humar, MD
Heart Injuries, Kidney Transplant; Complications
Perioperative Factors and Early Postoperative Kidney Graft Function Recovery
Divided into two groups based on acute kidney injury: non-acute kidney injury group vs. non-acute kidney injury group. Acute kidney injury group, Acute Kidney Injury Network (AKIN), Risk, Injury, Failure, Loss of kidney function…
- Trial name
- NCT06280898
- Testing
- Remote ischemic conditioning
- Where
- South Korea
- Volunteers
- 539 people
- Sponsor
- Seoul St. Mary's Hospital
Surgical Procedure, Unspecified, Non Small Cell Lung Cancer
Fissios© and Postoperative Complications (FPoC Trial)
Respiratory physiotherapy as part of a pre-operative physical training program may reduce the risk of developing post-operative complications, improving post-operative results and optimizing physical conditions in patients with a…
- Conditions
- Surgical Procedure, Unspecified, Non Small Cell Lung Cancer, Surgery Scheduled, Thoracic Surgery
- Trial name
- FPoC (NCT06732193)
- Testing
- On-site respiratory physiotherapy, Fissios App
- Where
- Spain
- Volunteers
- 560 people
- Sponsor
- Carlos Alfredo Fraile Olivero, MD, PhD.
Cleft Palate, Cleft Lip
Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring
Cleft lip and palate surgeries present unique anesthetic challenges due to shared airway access with the surgical field, frequent anatomical abnormalities, and a predominantly infant and toddler population.
- Conditions
- Cleft Palate, Cleft Lip, Laryngospasm, Bronchospasm
- Trial name
- NCT07651904
- Testing
- Standard General Anesthesia per Institutional Protocol
- Volunteers
- 150 people
- Sponsor
- Marmara University Pendik Training and Research Hospital